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In enzymology, a 1,2-alpha-L-fucosidase (EC is an enzyme that catalyzes the chemical reaction

methyl-2-alpha-L-fucopyranosyl-beta-D-galactoside + H2O L-fucose + methyl beta-D-galactoside

Thus, the two substrates of this enzyme are methyl-2-alpha-L-fucopyranosyl-beta-D-galactoside and H2O, whereas its two products are L-fucose and methyl beta-D-galactoside.

This enzyme belongs to the family of hydrolases, specifically those glycosidases that hydrolyse O- and S-glycosyl compounds. The systematic name of this enzyme class is 2-alpha-L-fucopyranosyl-beta-D-galactoside fucohydrolase. Other names in common use include almond emulsin fucosidase, and alpha-(1->2)-L-fucosidase.

Structural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes 2EAB, 2EAC, 2EAD, and 2EAE.


  • IUBMB entry for
  • BRENDA references for (Recommended.)
  • PubMed references for
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  • Bahl OP (1970). "Glycosidases of aspergillus niger. II. Purification and general properties of 1,2-alpha-L-fucosidase". J. Biol. Chem. 245: 299&ndash, 304. PMID 5460888.
  • Ogata-Arakawa M, Muramatsu T, Kobata A (1977). "alpha-L-fucosidases from almond emulsin: characterization of the two enzymes with different specificities". Arch. Biochem. Biophys. 181: 353&ndash, 8. PMID 18111.
  • Reglero A, Cabezas JA (1976). "Glycosidases of molluscs. Purification and properties of alpha-L-fucosidase from Chamelea gallina L". Eur. J. Biochem. 66: 379&ndash, 87. PMID 7458.

External links

The CAS registry number for this enzyme class is 37288-45-2.

Gene Ontology (GO) codes