(S)-methylmalonyl-CoA hydrolase

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In enzymology, a (S)-methylmalonyl-CoA hydrolase (EC is an enzyme that catalyzes the chemical reaction

(S)-methylmalonyl-CoA + H2O methylmalonate + CoA

Thus, the two substrates of this enzyme are (S)-methylmalonyl-CoA and H2O, whereas its two products are methylmalonate and CoA.

This enzyme belongs to the family of hydrolases, specifically those acting on thioester bonds. The systematic name of this enzyme class is (S)-methylmalonyl-CoA hydrolase. This enzyme is also called D-methylmalonyl-coenzyme A hydrolase. This enzyme participates in propanoate metabolism.


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  • Kovachy RJ, Copley SD, Allen RH (1983). "Recognition, isolation, and characterization of rat liver D-methylmalonyl coenzyme A hydrolase". J. Biol. Chem. 258: 11415&ndash, 21. PMID 6885824.

External links

The CAS registry number for this enzyme class is 87928-03-8.

Gene Ontology (GO) codes