Oxygen Enhancement Ratio
Overview
The Oxygen Enhancement Ratio (OER) in radiobiology refers to the enhancement of therapeutic or detrimental effect of ionizing radiation due to the presence of oxygen. The effect is most notable in ionizing radiation dose.
Uses in medicine
The effect is used in medical physics to increase the effect of radiation therapy in oncology treatments. Additional oxygen abundance creates additional free radicals and increases the damage to the target tissue.
In solid tumors the inner parts become less oxygenated than normal tissue and up to three times higher dose is needed to achieve the same tumor control probability as in tissue with normal oxygenation.
See also
References
Eric J. Hall and Amato J. Giaccia: Radiobiology for the radiologist, Lippincott Williams & Wilkins, 6th Ed., 2006