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A zymogen (or proenzyme) is an inactive enzyme precursor. A zymogen requires a biochemical change (such as a hydrolysis reaction revealing the active site, or changing the configuration to reveal the active site) for it to become an active enzyme. The biochemical change usually occurs in a lysosome where a specific part of the precursor enzyme is cleaved in order to activate it. The amino acid chain that is released upon activation is called the activation peptide.


Very often the suffix "-ogen" can be added to the name of the enzyme to indicate that it is in the precursor form. Some enzymes have a pro- prefix to denote their inactive status e.g. Proalbumin, which is converted into albumin. [2]


Examples of zymogens:

See also

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| group5 = Clinical Trials Involving Zymogen | list5 = Ongoing Trials on Zymogen at Clinical Trials.govTrial results on ZymogenClinical Trials on Zymogen at Google

| group6 = Guidelines / Policies / Government Resources (FDA/CDC) Regarding Zymogen | list6 = US National Guidelines Clearinghouse on ZymogenNICE Guidance on ZymogenNHS PRODIGY GuidanceFDA on ZymogenCDC on Zymogen

| group7 = Textbook Information on Zymogen | list7 = Books and Textbook Information on Zymogen

| group8 = Pharmacology Resources on Zymogen | list8 = AND (Dose)}} Dosing of ZymogenAND (drug interactions)}} Drug interactions with ZymogenAND (side effects)}} Side effects of ZymogenAND (Allergy)}} Allergic reactions to ZymogenAND (overdose)}} Overdose information on ZymogenAND (carcinogenicity)}} Carcinogenicity information on ZymogenAND (pregnancy)}} Zymogen in pregnancyAND (pharmacokinetics)}} Pharmacokinetics of Zymogen

| group9 = Genetics, Pharmacogenomics, and Proteinomics of Zymogen | list9 = AND (pharmacogenomics)}} Genetics of ZymogenAND (pharmacogenomics)}} Pharmacogenomics of ZymogenAND (proteomics)}} Proteomics of Zymogen

| group10 = Newstories on Zymogen | list10 = Zymogen in the newsBe alerted to news on ZymogenNews trends on Zymogen

| group11 = Commentary on Zymogen | list11 = Blogs on Zymogen

| group12 = Patient Resources on Zymogen | list12 = Patient resources on ZymogenDiscussion groups on ZymogenPatient Handouts on ZymogenDirections to Hospitals Treating ZymogenRisk calculators and risk factors for Zymogen

| group13 = Healthcare Provider Resources on Zymogen | list13 = Symptoms of ZymogenCauses & Risk Factors for ZymogenDiagnostic studies for ZymogenTreatment of Zymogen

| group14 = Continuing Medical Education (CME) Programs on Zymogen | list14 = CME Programs on Zymogen

| group15 = International Resources on Zymogen | list15 = Zymogen en EspanolZymogen en Francais

| group16 = Business Resources on Zymogen | list16 = Zymogen in the MarketplacePatents on Zymogen

| group17 = Informatics Resources on Zymogen | list17 = List of terms related to Zymogen


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