Zika virus infection pathophysiology: Difference between revisions
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===Pathogenesis=== | ===Pathogenesis=== | ||
*Mosquito-borne | *Mosquito-borne Zika virus is thought to initially replicate in dendritic cells near the site of [[Inoculation|inoculation]] before spreading to [[Lymph node|lymph nodes]] and then the [[Blood|bloodstream]]. | ||
* | *One study indicates that Zika virus replicates in cellular nuclei, as opposed to other flaviviruses that do so in the cytoplasm.<ref name="pmid2841406">{{cite journal| author=Buckley A, Gould EA| title=Detection of virus-specific antigen in the nuclei or nucleoli of cells infected with Zika or Langat virus. | journal=J Gen Virol | year= 1988 | volume= 69 ( Pt 8) | issue= | pages= 1913-20 | pmid=2841406 | doi=10.1099/0022-1317-69-8-1913 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=2841406 }} </ref> | ||
*Zika virus can be killed by potassium permanganate, ether, temperatures >60°C, but is not effectively neutralized by 10% ethanol.<ref name="pmid19788800"></ref> | |||
==Gross Pathology== | ==Gross Pathology== | ||
Revision as of 15:26, 18 December 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Nate Michalak, B.A.
Overview
Pathophysiology
Transmission
- Zika virus is primarily transmitted to humans via the bite of an infected Aedes mosquito. These mosquitoes are also vectors for dengue and chikungunya viruses.[1][2]
- Transmission of Zika virus to a fetus from an infected mother is possible but rare.
- Zika virus has also been proven to be sexually transmitted between humans by Brian Foy, a biologist at Colorado State University.[3]
- There are no reports of infants acquiring Zika virus through breastfeeding.
- Transmission through blood transfusion is possible as Zika virus has been identified in asymptomatic donors during an ongoing outbreak.[2]
Pathogenesis
- Mosquito-borne Zika virus is thought to initially replicate in dendritic cells near the site of inoculation before spreading to lymph nodes and then the bloodstream.
- One study indicates that Zika virus replicates in cellular nuclei, as opposed to other flaviviruses that do so in the cytoplasm.[4]
- Zika virus can be killed by potassium permanganate, ether, temperatures >60°C, but is not effectively neutralized by 10% ethanol.[1]
Gross Pathology
Microscopic Pathology
References
- ↑ 1.0 1.1 Hayes EB (2009). "Zika virus outside Africa". Emerg Infect Dis. 15 (9): 1347–50. doi:10.3201/eid1509.090442. PMC 2819875. PMID 19788800.
- ↑ 2.0 2.1 Zika Virus Transmission. Centers for Disease Control and Prevention (June 1, 2015). http://www.cdc.gov/zika/transmission/index.html Accessed on December 17, 2015
- ↑ Foy, B. D.; Kobylinski, K. C.; Foy, J. L. C.; Blitvich, B. J.; Travassos Da Rosa, A.; Haddow, A. D.; Lanciotti, R. S.; Tesh, R. B. (2011). "Probable Non–Vector-borne Transmission of Zika Virus, Colorado, USA". Emerging Infectious Diseases. 17 (5): 880–882. doi:10.3201/eid1705.101939. PMC 3321795. PMID 21529401.
- ↑ Buckley A, Gould EA (1988). "Detection of virus-specific antigen in the nuclei or nucleoli of cells infected with Zika or Langat virus". J Gen Virol. 69 ( Pt 8): 1913–20. doi:10.1099/0022-1317-69-8-1913. PMID 2841406.