Zika virus infection laboratory findings: Difference between revisions
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==Laboratory Findings== | ==Laboratory Findings== | ||
*During the first week after onset of symptoms, Zika virus can often be diagnosed by performing reverse transcriptase-polymerase chain reaction (RT-PCR) on serum. | *During the first week after onset of symptoms, Zika virus can often be diagnosed by performing reverse transcriptase-polymerase chain reaction (RT-PCR) on serum. | ||
* | *ELISA can be used to detect virus-specific IgM and neutralizing antibodies toward the end of the first week of illness. | ||
*Cross-reaction with related flaviviruses (e.g., dengue and West Nile viruses) is common and may be difficult to discern. | *Cross-reaction with related flaviviruses (e.g., dengue and West Nile viruses) is common and may be difficult to discern. | ||
*Plaque-reduction neutralization testing can be performed to measure virus-specific neutralizing antibodies and discriminate between cross-reacting antibodies in primary flavivirus infections.<ref>For HealthCare Providers: Diagnostic Testing. Center for Disease Control and Prevention (June 1, 2015). http://www.cdc.gov/zika/hc-providers/diagnostic.html Accessed December 21, 2015.</ref> | *Plaque-reduction neutralization testing can be performed to measure virus-specific neutralizing antibodies and discriminate between cross-reacting antibodies in primary flavivirus infections.<ref>For HealthCare Providers: Diagnostic Testing. Center for Disease Control and Prevention (June 1, 2015). http://www.cdc.gov/zika/hc-providers/diagnostic.html Accessed December 21, 2015.</ref> | ||
Revision as of 15:42, 21 December 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Nate Michalak, B.A.
Overview
Blood serum and plasma testing is conducted to detect viral nucleic acids or virus specific IgM. Laboratory testing is the primary source when differentiating between Zika and other commonly misdiagnosed viruses.[1]
Laboratory Findings
- During the first week after onset of symptoms, Zika virus can often be diagnosed by performing reverse transcriptase-polymerase chain reaction (RT-PCR) on serum.
- ELISA can be used to detect virus-specific IgM and neutralizing antibodies toward the end of the first week of illness.
- Cross-reaction with related flaviviruses (e.g., dengue and West Nile viruses) is common and may be difficult to discern.
- Plaque-reduction neutralization testing can be performed to measure virus-specific neutralizing antibodies and discriminate between cross-reacting antibodies in primary flavivirus infections.[2]
References
- ↑ Zika virus. Center for Disease Control and Prevention for Medical Professionals. http://www.cdc.gov/zika/hc-providers/clinicalevaluation.html Accessed on December 10, 2015
- ↑ For HealthCare Providers: Diagnostic Testing. Center for Disease Control and Prevention (June 1, 2015). http://www.cdc.gov/zika/hc-providers/diagnostic.html Accessed December 21, 2015.