ZW10

ZW10, kinetochore associated, homolog (Drosophila)
Identifiers
Symbols	ZW10 ; HZW10; KNTC1AP; MGC149821
External IDs	Template:OMIM5 Template:MGI HomoloGene: 37959
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE ZW10 204812 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

ZW10, kinetochore associated, homolog (Drosophila), also known as ZW10, is a human gene.

This gene encodes a protein that is one of many involved in mechanisms to ensure proper chromosome segregation during cell division. The encoded protein binds to centromeres during the prophase, metaphase, and early anaphase cell division stages and to kinetochore microtubules during metaphase.

Further reading

• Starr DA, Williams BC, Li Z; et al. (1997). "Conservation of the centromere/kinetochore protein ZW10". J. Cell Biol. 138 (6): 1289–301. PMID 9298984.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Starr DA, Williams BC, Hays TS, Goldberg ML (1998). "ZW10 helps recruit dynactin and dynein to the kinetochore". J. Cell Biol. 142 (3): 763–74. PMID 9700164.CS1 maint: Multiple names: authors list (link)
• Starr DA, Saffery R, Li Z; et al. (2000). "HZwint-1, a novel human kinetochore component that interacts with HZW10". J. Cell. Sci. 113 ( Pt 11): 1939–50. PMID 10806105.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chan GK, Jablonski SA, Starr DA; et al. (2001). "Human Zw10 and ROD are mitotic checkpoint proteins that bind to kinetochores". Nat. Cell Biol. 2 (12): 944–7. doi:10.1038/35046598. PMID 11146660.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Scaërou F, Starr DA, Piano F; et al. (2001). "The ZW10 and Rough Deal checkpoint proteins function together in a large, evolutionarily conserved complex targeted to the kinetochore". J. Cell. Sci. 114 (Pt 17): 3103–14. PMID 11590237.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gevaert K, Goethals M, Martens L; et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hirose H, Arasaki K, Dohmae N; et al. (2005). "Implication of ZW10 in membrane trafficking between the endoplasmic reticulum and Golgi". EMBO J. 23 (6): 1267–78. doi:10.1038/sj.emboj.7600135. PMID 15029241.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Musio A, Mariani T, Montagna C; et al. (2004). "Recapitulation of the Roberts syndrome cellular phenotype by inhibition of INCENP, ZWINT-1 and ZW10 genes". Gene. 331: 33–40. doi:10.1016/j.gene.2004.01.028. PMID 15094189.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nakajima K, Hirose H, Taniguchi M; et al. (2005). "Involvement of BNIP1 in apoptosis and endoplasmic reticulum membrane fusion". EMBO J. 23 (16): 3216–26. doi:10.1038/sj.emboj.7600333. PMID 15272311.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wang H, Hu X, Ding X; et al. (2005). "Human Zwint-1 specifies localization of Zeste White 10 to kinetochores and is essential for mitotic checkpoint signaling". J. Biol. Chem. 279 (52): 54590–8. doi:10.1074/jbc.M407588200. PMID 15485811.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kops GJ, Kim Y, Weaver BA; et al. (2005). "ZW10 links mitotic checkpoint signaling to the structural kinetochore". J. Cell Biol. 169 (1): 49–60. doi:10.1083/jcb.200411118. PMID 15824131.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Varma D, Dujardin DL, Stehman SA, Vallee RB (2006). "Role of the kinetochore/cell cycle checkpoint protein ZW10 in interphase cytoplasmic dynein function". J. Cell Biol. 172 (5): 655–62. doi:10.1083/jcb.200510120. PMID 16505164.CS1 maint: Multiple names: authors list (link)
• Nousiainen M, Silljé HH, Sauer G; et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. doi:10.1073/pnas.0507066103. PMID 16565220.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Arasaki K, Taniguchi M, Tani K, Tagaya M (2006). "RINT-1 regulates the localization and entry of ZW10 to the syntaxin 18 complex". Mol. Biol. Cell. 17 (6): 2780–8. doi:10.1091/mbc.E05-10-0973. PMID 16571679.CS1 maint: Multiple names: authors list (link)
• Lin YT, Chen Y, Wu G, Lee WH (2006). "Hec1 sequentially recruits Zwint-1 and ZW10 to kinetochores for faithful chromosome segregation and spindle checkpoint control". Oncogene. 25 (52): 6901–14. doi:10.1038/sj.onc.1209687. PMID 16732327.CS1 maint: Multiple names: authors list (link)
• Ewing RM, Chu P, Elisma F; et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Arasaki K, Uemura T, Tani K, Tagaya M (2007). "Correlation of Golgi localization of ZW10 and centrosomal accumulation of dynactin". Biochem. Biophys. Res. Commun. 359 (3): 811–6. doi:10.1016/j.bbrc.2007.05.188. PMID 17560939.CS1 maint: Multiple names: authors list (link)
• Sun Y, Shestakova A, Hunt L; et al. (2007). "Rab6 regulates both ZW10/RINT-1 and conserved oligomeric Golgi complex-dependent Golgi trafficking and homeostasis". Mol. Biol. Cell. 18 (10): 4129–42. doi:10.1091/mbc.E07-01-0080. PMID 17699596.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)