ZFPM2

Zinc finger protein, multitype 2
Identifiers
Symbols	ZFPM2 ; DIH3; FOG2; MGC129663; MGC129664; ZNF89B; hFOG-2
External IDs	Template:OMIM5 Template:MGI HomoloGene: 8008
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE ZFPM2 219778 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Zinc finger protein, multitype 2, also known as ZFPM2, is a human gene.

The zinc finger protein encoded by this gene is a widely expressed member of the FOG family of transcription factors. The family members modulate the activity of GATA family proteins, which are important regulators of hematopoiesis and cardiogenesis in mammals. It has been demonstrated that the protein can both activate and down-regulate expression of GATA-target genes, suggesting different modulation in different promoter contexts. A related mRNA suggests an alternatively spliced product but this information is not yet fully supported by the sequence.

Further reading

• Svensson EC, Tufts RL, Polk CE, Leiden JM (1999). "Molecular cloning of FOG-2: a modulator of transcription factor GATA-4 in cardiomyocytes". Proc. Natl. Acad. Sci. U.S.A. 96 (3): 956–61. PMID 9927675.CS1 maint: Multiple names: authors list (link)
• Fox AH, Liew C, Holmes M; et al. (1999). "Transcriptional cofactors of the FOG family interact with GATA proteins by means of multiple zinc fingers". EMBO J. 18 (10): 2812–22. doi:10.1093/emboj/18.10.2812. PMID 10329627.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Holmes M, Turner J, Fox A; et al. (1999). "hFOG-2, a novel zinc finger protein, binds the co-repressor mCtBP2 and modulates GATA-mediated activation". J. Biol. Chem. 274 (33): 23491–8. PMID 10438528.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Crispino JD, Lodish MB, Thurberg BL; et al. (2001). "Proper coronary vascular development and heart morphogenesis depend on interaction of GATA-4 with FOG cofactors". Genes Dev. 15 (7): 839–44. doi:10.1101/gad.875201. PMID 11297508.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Anttonen M, Ketola I, Parviainen H; et al. (2004). "FOG-2 and GATA-4 Are coexpressed in the mouse ovary and can modulate mullerian-inhibiting substance expression". Biol. Reprod. 68 (4): 1333–40. doi:10.1095/biolreprod.102.008599. PMID 12606418.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Pizzuti A, Sarkozy A, Newton AL; et al. (2004). "Mutations of ZFPM2/FOG2 gene in sporadic cases of tetralogy of Fallot". Hum. Mutat. 22 (5): 372–7. doi:10.1002/humu.10261. PMID 14517948.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hirai M, Ono K, Morimoto T; et al. (2004). "FOG-2 competes with GATA-4 for transcriptional coactivator p300 and represses hypertrophic responses in cardiac myocytes". J. Biol. Chem. 279 (36): 37640–50. doi:10.1074/jbc.M401737200. PMID 15220332.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chan EM, Comer EM, Brown FC; et al. (2005). "AML1-FOG2 fusion protein in myelodysplasia". Blood. 105 (11): 4523–6. doi:10.1182/blood-2004-07-2762. PMID 15705784.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ackerman KG, Herron BJ, Vargas SO; et al. (2005). "Fog2 is required for normal diaphragm and lung development in mice and humans". PLoS Genet. 1 (1): 58–65. doi:10.1371/journal.pgen.0010010. PMID 16103912.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lim J, Hao T, Shaw C; et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Finelli P, Pincelli AI, Russo S; et al. (2007). "Disruption of friend of GATA 2 gene (FOG-2) by a de novo t(8;10) chromosomal translocation is associated with heart defects and gonadal dysgenesis". Clin. Genet. 71 (3): 195–204. doi:10.1111/j.1399-0004.2007.00752.x. PMID 17309641.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bleyl SB, Moshrefi A, Shaw GM; et al. (2007). "Candidate genes for congenital diaphragmatic hernia from animal models: sequencing of FOG2 and PDGFRalpha reveals rare variants in diaphragmatic hernia patients". Eur. J. Hum. Genet. 15 (9): 950–8. doi:10.1038/sj.ejhg.5201872. PMID 17568391.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)