YWHAQ
| Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide | |||||||||||||
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File:PBB Protein YWHAQ image.jpg PDB rendering based on 2btp. | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | YWHAQ ; HS1; 14-3-3; 1C5 | ||||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 48407 | ||||||||||||
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| RNA expression pattern | |||||||||||||
| File:PBB GE YWHAQ 212426 s at tn.png | |||||||||||||
| File:PBB GE YWHAQ 200693 at tn.png | |||||||||||||
| File:PBB GE YWHAQ 213699 s at tn.png | |||||||||||||
| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Template:GNF Ortholog box | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | n/a | n/a | |||||||||||
| Ensembl | n/a | n/a | |||||||||||
| UniProt | n/a | n/a | |||||||||||
| RefSeq (mRNA) | n/a | n/a | |||||||||||
| RefSeq (protein) | n/a | n/a | |||||||||||
| Location (UCSC) | n/a | n/a | |||||||||||
| PubMed search | n/a | n/a | |||||||||||
Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide, also known as YWHAQ, is a human gene.
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse and rat orthologs. This gene is upregulated in patients with amyotrophic lateral sclerosis. It contains in its 5' UTR a 6 bp tandem repeat sequence which is polymorphic, however, there is no correlation between the repeat number and the disease.[1]
References
Further reading
- Kino T, Chrousos GP (2004). "Human immunodeficiency virus type-1 accessory protein Vpr: a causative agent of the AIDS-related insulin resistance/lipodystrophy syndrome?". Ann. N. Y. Acad. Sci. 1024: 153–67. doi:10.1196/annals.1321.013. PMID 15265780.
- Calinisan V, Gravem D, Chen RP; et al. (2006). "New insights into potential functions for the protein 4.1 superfamily of proteins in kidney epithelium". Front. Biosci. 11: 1646–66. PMID 16368544.
- Nielsen PJ (1991). "Primary structure of a human protein kinase regulator protein". Biochim. Biophys. Acta. 1088 (3): 425–8. PMID 2015305.
- Bonnefoy-Bérard N, Liu YC, von Willebrand M; et al. (1995). "Inhibition of phosphatidylinositol 3-kinase activity by association with 14-3-3 proteins in T cells". Proc. Natl. Acad. Sci. U.S.A. 92 (22): 10142–6. PMID 7479742.
- Xiao B, Smerdon SJ, Jones DH; et al. (1995). "Structure of a 14-3-3 protein and implications for coordination of multiple signalling pathways". Nature. 376 (6536): 188–91. doi:10.1038/376188a0. PMID 7603573.
- Leffers H, Madsen P, Rasmussen HH; et al. (1993). "Molecular cloning and expression of the transformation sensitive epithelial marker stratifin. A member of a protein family that has been involved in the protein kinase C signalling pathway". J. Mol. Biol. 231 (4): 982–98. doi:10.1006/jmbi.1993.1346. PMID 8515476.
- Andersson B, Wentland MA, Ricafrente JY; et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
- Liu YC, Elly C, Yoshida H; et al. (1996). "Activation-modulated association of 14-3-3 proteins with Cbl in T cells". J. Biol. Chem. 271 (24): 14591–5. PMID 8663231.
- Papin C, Denouel A, Calothy G, Eychène A (1996). "Identification of signalling proteins interacting with B-Raf in the yeast two-hybrid system". Oncogene. 12 (10): 2213–21. PMID 8668348.
- Zha J, Harada H, Yang E; et al. (1997). "Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)". Cell. 87 (4): 619–28. PMID 8929531.
- Suzuki Y, Demoliere C, Kitamura D; et al. (1997). "HAX-1, a novel intracellular protein, localized on mitochondria, directly associates with HS1, a substrate of Src family tyrosine kinases". J. Immunol. 158 (6): 2736–44. PMID 9058808.
- Yu W, Andersson B, Worley KC; et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. PMID 9110174.
- Dubois T, Rommel C, Howell S; et al. (1997). "14-3-3 is phosphorylated by casein kinase I on residue 233. Phosphorylation at this site in vivo regulates Raf/14-3-3 interaction". J. Biol. Chem. 272 (46): 28882–8. PMID 9360956.
- Hsu SY, Kaipia A, Zhu L, Hsueh AJ (1997). "Interference of BAD (Bcl-xL/Bcl-2-associated death promoter)-induced apoptosis in mammalian cells by 14-3-3 isoforms and P11". Mol. Endocrinol. 11 (12): 1858–67. PMID 9369453.
- Brunati AM, Donella-Deana A, James P; et al. (1999). "Molecular features underlying the sequential phosphorylation of HS1 protein and its association with c-Fgr protein-tyrosine kinase". J. Biol. Chem. 274 (11): 7557–64. PMID 10066823.
- Hausser A, Storz P, Link G; et al. (1999). "Protein kinase C mu is negatively regulated by 14-3-3 signal transduction proteins". J. Biol. Chem. 274 (14): 9258–64. PMID 10092600.
- Finlin BS, Andres DA (1999). "Phosphorylation-dependent association of the Ras-related GTP-binding protein Rem with 14-3-3 proteins". Arch. Biochem. Biophys. 368 (2): 401–12. doi:10.1006/abbi.1999.1316. PMID 10441394.
- Chow CW, Davis RJ (2000). "Integration of calcium and cyclic AMP signaling pathways by 14-3-3". Mol. Cell. Biol. 20 (2): 702–12. PMID 10611249.
- Mori H, Inoue M, Yano M; et al. (2000). "14-3-3tau associates with a translational control factor FKBP12-rapamycin-associated protein in T-cells after stimulation by pervanadate". FEBS Lett. 467 (1): 61–4. PMID 10664457.
- Mils V, Baldin V, Goubin F; et al. (2000). "Specific interaction between 14-3-3 isoforms and the human CDC25B phosphatase". Oncogene. 19 (10): 1257–65. doi:10.1038/sj.onc.1203419. PMID 10713667.
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.