Wilson's disease natural history, complications and prognosis

Wilson's disease Microchapters
Home
Patient Information
Overview
Historical Perspective
Classification
Pathophysiology
Causes
Differentiating Wilson's disease from other Diseases
Epidemiology and Demographics
Risk Factors
Screening
Natural History, Complications and Prognosis
Diagnosis
Diagnostic Study of Choice
History and Symptoms
Physical Examination
Laboratory Findings
Electrocardiogram
X-ray
CT
MRI
Echocardiography or Ultrasound
Other Imaging Findings
Other Diagnostic Studies
Treatment
Medical Therapy
Surgery
Primary Prevention
Secondary Prevention
Cost-Effectiveness of Therapy
Future or Investigational Therapies
Wilson's disease natural history, complications and prognosis On the Web
Most recent articles
cited articles
Review articles
CME Programs
Powerpoint slides
Images
American Roentgen Ray Society Images of Wilson's disease natural history, complications and prognosis All Images X-rays Echo & Ultrasound CT Images MRI
Ongoing Trials at Clinical Trials.gov
US National Guidelines Clearinghouse
NICE Guidance
FDA on Wilson's disease natural history, complications and prognosis
CDC on Wilson's disease natural history, complications and prognosis
Wilson's disease natural history, complications and prognosis in the news
Blogs on Wilson's disease natural history, complications and prognosis
Directions to Hospitals Treating Wilson's disease
Risk calculators and risk factors for Wilson's disease natural history, complications and prognosis

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ahmed Elsaiey, MBBCH [2]

Overview

If left untreated, Wilson's disease will lead to death as the copper accumulation in the liver and brain will lead to cirrhosis and severe dystonia respectively. Common complications of Wilson's disease include hepatocellular carcinoma, renal failure, and persistent neurological manifestations. Prognosis of Wilson's disease is usually good in case of early detection and proper treatment.

Natural History, Complications, and Prognosis

Natural history

• The symptoms of Wilson's disease usually develop between age of 5 and 35 years. However, the symptoms can be presented at any age onset.
• If left untreated, Wilson's disease will lead to death. The copper accumulation in the liver and the brain will end up with cirrhosis and severe dystonia respectively.

Complications

• Common complications of Wilson's disease include the following:
  • Cirrhosis
  • Hepatocellular carcinoma
  • Persistent the neurological manifestations
  • Renal complications as kidney stones and renal failure
  • Hemolytic anemia

Prognosis

• Prognosis of Wilson's disease is usually good with early detection and proper treatment except in the severely advanced patients.