Waldenström's macroglobulinemia history and symptoms

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Mirdula Sharma, MBBS [2]

Overview

History and Symptoms

Asymptomatic or Smoldering:

Presents in 30% of patients with Waldenström's macroglobulinemia.^[1]

Symptomatic:

Constitutional symptoms

Weight loss^[1]
Fever
Night sweat
Lymphedema

Hyperviscosity syndrome

Accumulation of IgM proteins in blood can increase the viscosity of blood, slowing down the flow of blood to different organs. Symptoms of hyperviscosity include:^[1]

Retinal hemorrhage with blurring of vision problem
Vertigo
Dizziness
Headache
Oronasal bleeding

Bone marrow infiltration

Anemia^[2]
Pancytopenia

References

↑ ^1.0 ^1.1 ^1.2 Waldenström's macroglobulinemia symptoms and signs. Cancer.Net (2015)http://www.cancer.net/cancer-types/waldenstrom’s-macroglobulinemia/symptoms-and-signs Accessed on November 10, 2015
↑ Monge J, Braggio E, Ansell SM (2013). "Genetic factors and pathogenesis of Waldenström's macroglobulinemia". Curr Oncol Rep. 15 (5): 450–6. doi:10.1007/s11912-013-0331-7. PMC 3807757. PMID 23901022.

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[HS-1] 1.0 ^1.1 ^1.2 Waldenström's macroglobulinemia symptoms and signs. Cancer.Net (2015)http://www.cancer.net/cancer-types/waldenstrom’s-macroglobulinemia/symptoms-and-signs Accessed on November 10, 2015

[pmid23901022-2] Monge J, Braggio E, Ansell SM (2013). "Genetic factors and pathogenesis of Waldenström's macroglobulinemia". Curr Oncol Rep. 15 (5): 450–6. doi:10.1007/s11912-013-0331-7. PMC 3807757. PMID 23901022.

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[2]