Waldenström's macroglobulinemia history and symptoms: Difference between revisions

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Revision as of 20:48, 6 November 2015

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

History and Symptoms

Patients with WM may present with various symptoms.

Approximately 30% of the patients are asymptomatic (smoldering WM).
Anemia with mean hemoglobin less than 10 g/dL - fatigue
Bone marrow infiltration: cause anemia & pancytopenia
Extramedullary infiltration - hepatomegaly, splenomegaly, lymphadenopathy
Hyperviscosity - oronasal bleeding, retinal hemorrhage with blurring or loss of vision, headache, vertigo, ataxia
IgM monoclonal proteins - peripheral neuropathy

References

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@@ Line 4: / Line 4: @@
 ==Overview==
 ==History and Symptoms==
-Symptoms of WM include
+Patients with WM may present with various symptoms.
-* [[Weakness]]
+*Approximately 30% of the patients are asymptomatic (smoldering WM).
-* [[fatigue (physical)|Fatigue]]
+*Anemia with mean hemoglobin less than 10 g/dL - fatigue
-* [[Weight loss]]
+*Bone marrow infiltration: cause anemia & pancytopenia
-* [[Loss of vision]]
+*Extramedullary infiltration - hepatomegaly, splenomegaly, lymphadenopathy
-* [[Headache]]
+*Hyperviscosity - oronasal bleeding, retinal hemorrhage with blurring or loss of vision, headache, vertigo, ataxia
-* [[Stroke]]
+*IgM monoclonal proteins - peripheral neuropathy
-* [[Coma]]<ref name="Owen">{{cite journal | author=Owen RG, Barrans SL, Richards SJ, O'Connor SJ, Child JA, Parapia LA, Morgan GJ, Jack AS | title=Waldenstrom macroglobulinemia. Development of diagnostic criteria and identification of prognostic factors | journal=Am J Clin Pathol | year=2001 | pages=420-8 | volume=116 | issue=3  | id=PMID 11554171}}</ref><ref name="SanMiguel">{{cite journal | author=San Miguel JF, Vidriales MB, Ocio E, Mateo G, Sanchez-Guijo F, Sanchez ML, Escribano L, Barez A, Moro MJ, Hernandez J, Aguilera C, Cuello R, Garcia-Frade J, Lopez R, Portero J, Orfao A | title=Immunophenotypic analysis of Waldenstrom's macroglobulinemia | journal=Semin Oncol | year=2003 | pages=187-95 | volume=30 | issue=2  | id=PMID 12720134}}</ref><ref name="Ghobrial">{{cite journal | author=Ghobrial IM, Witzig TE | title=Waldenstrom macroglobulinemia | journal=Curr Treat Options Oncol | year=2004 | pages=239-47 | volume=5 | issue=3  | id=PMID 15115652}}</ref>
-* Chronic oozing of blood from the nose and gums.<ref name="Kyle1988">{{cite book | author =Kyle RA  | year = 1998 | title = Internal Medicine | chapter = Chapter 94: Multiple Myeloma and the Dysproteinemias | editor = Stein JH | edition = 5th ed. | publisher = C.V.Mosby | location = New York | id = ISBN 0815186983 }}</ref>
 ==References==

Waldenström's macroglobulinemia history and symptoms: Difference between revisions

Revision as of 20:48, 6 November 2015

Overview

History and Symptoms

References

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