WBR0446
| Author | [[PageAuthor::Rim Halaby, M.D. [1]]] |
|---|---|
| Exam Type | ExamType::USMLE Step 1 |
| Main Category | MainCategory::Pathology |
| Sub Category | SubCategory::Endocrine |
| Prompt | [[Prompt::A 45 year old female patient who is previously healthy presents to her physician’s office complaining of severe diarrhea since several days. The patient’s past medical history is also significant for recurrent kidney stones and parathyroidectomy. Fasting gastrin level is elevated. Endoscopy reveals multiple ulcers in the stomach, duodenum, and the jejunum. Which of the following is the most likely additional finding in this patient?]] |
| Answer A | AnswerA::Oral ganglioneuroma |
| Answer A Explanation | AnswerAExp::Oral ganglioneuromatosis is seen in patients with MEN2B syndrome. |
| Answer B | AnswerB::Pheochromocytoma |
| Answer B Explanation | AnswerBExp::Pheochromocytoma can be found in MEN 2A and MEN 2B syndromes. |
| Answer C | AnswerC::Medullary thyroid cancer |
| Answer C Explanation | AnswerCExp::Medullary thyroid cancer can be found in MEN 2A and MEN 2B syndromes. |
| Answer D | AnswerD::Prolactinoma |
| Answer D Explanation | AnswerDExp::Prolactinoma, a pituitary tumor, can be found in MEN I syndrome. |
| Answer E | AnswerE::Carcinoid tumor |
| Answer E Explanation | AnswerEExp::Carcinoid tumor is an endocrine tumor but is not associated with any MEN syndrome. |
| Right Answer | RightAnswer::D |
| Explanation | [[Explanation::Men I syndrome is characterized by parathyroid tumors, pituitary tumors that are usually prolactinoma or GH secreting tumors, and pancreatic endocrine tumors, such as gastrinoma, insulinoma, VIPoma, or glucagonoma.
Educational Objective:
MEN I syndrome is characterized by pituitary tumor, parathyroid tumor, and pancreatic endocrine tumor. |
| Approved | Approved::No |
| Keyword | WBRKeyword::Prolactinoma, WBRKeyword::pheochromocytoma, WBRKeyword::gastrinoma, WBRKeyword::multiple, WBRKeyword::endocrine, WBRKeyword::neoplasia, WBRKeyword::MEN I, WBRKeyword::syndrome, WBRKeyword::Wermer’s, WBRKeyword::tumor |
| Linked Question | Linked:: |
| Order in Linked Questions | LinkedOrder:: |