Von Willebrand disease epidemiology and demographics: Difference between revisions

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==Epidemiology and Demographics==
==Epidemiology and Demographics==
In humans, the incidence of vWD is roughly about 1 in 100 individuals. Because most forms are rather mild, they are detected more often in women, whose bleeding tendency shows during [[menstruation]]. The actual abnormality (which does not necessarily lead to disease) occurs in 0.9-3% of the population. It may be more severe or apparent in people with [[blood type]] O.
===Prevalence===
The prevalence of von Willebrand’s disease is 0.6 to 1.3%.<ref name="pmid18315614">{{cite journal| author=Nichols WL, Hultin MB, James AH, Manco-Johnson MJ, Montgomery RR, Ortel TL et al.| title=von Willebrand disease (VWD): evidence-based diagnosis and management guidelines, the National Heart, Lung, and Blood Institute (NHLBI) Expert Panel report (USA). | journal=Haemophilia | year= 2008 | volume= 14 | issue= 2 | pages= 171-232 | pmid=18315614 | doi=10.1111/j.1365-2516.2007.01643.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18315614  }} </ref><ref name="pmid3492222">{{cite journal| author=Rodeghiero F, Castaman G, Dini E| title=Epidemiological investigation of the prevalence of von Willebrand's disease. | journal=Blood | year= 1987 | volume= 69 | issue= 2 | pages= 454-9 | pmid=3492222 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=3492222  }} </ref>
It is estimated that the referral prevalence of von Willebrand’s disease is approximately 1 case per 10,000 persons.  
 
The actual abnormality (which does not necessarily lead to disease) occurs in 0.9-3% of the population.
 
===Age===
 
 
===Gender===
Although autosomal inheritance pattern of disease lead to an equal distribution of male patients and female patients, the disease has female predominance whose bleeding tendency shows during [[menstruation]].
 
===Race===
 
There is no racial predilection to [[vWD]] however, it may be more severe or apparent in people with [[blood type]] O.


==References==
==References==

Revision as of 16:56, 28 November 2016

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Overview

Epidemiology and Demographics

Prevalence

The prevalence of von Willebrand’s disease is 0.6 to 1.3%.[1][2] It is estimated that the referral prevalence of von Willebrand’s disease is approximately 1 case per 10,000 persons.

The actual abnormality (which does not necessarily lead to disease) occurs in 0.9-3% of the population.

Age

Gender

Although autosomal inheritance pattern of disease lead to an equal distribution of male patients and female patients, the disease has female predominance whose bleeding tendency shows during menstruation.

Race

There is no racial predilection to vWD however, it may be more severe or apparent in people with blood type O.

References

  1. Nichols WL, Hultin MB, James AH, Manco-Johnson MJ, Montgomery RR, Ortel TL; et al. (2008). "von Willebrand disease (VWD): evidence-based diagnosis and management guidelines, the National Heart, Lung, and Blood Institute (NHLBI) Expert Panel report (USA)". Haemophilia. 14 (2): 171–232. doi:10.1111/j.1365-2516.2007.01643.x. PMID 18315614.
  2. Rodeghiero F, Castaman G, Dini E (1987). "Epidemiological investigation of the prevalence of von Willebrand's disease". Blood. 69 (2): 454–9. PMID 3492222.

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