Von Willebrand disease epidemiology and demographics: Difference between revisions

Jump to navigation Jump to search
No edit summary
 
(5 intermediate revisions by one other user not shown)
Line 1: Line 1:
__NOTOC__
__NOTOC__
{{Von Willebrand disease}}
{{Von Willebrand disease}}
{{CMG}}
{{CMG}} {{AE}} {{PTD}}
 


==Overview==
==Overview==
The prevalence of von Willebrand’s disease is 0.6 to 1.3%. It is estimated that the referral prevalence of von Willebrand’s disease is approximately 1 case per 10,000 persons. The actual abnormality (which does not necessarily lead to disease) occurs in 0.9-3% of the population. The symptoms of VWD is disproportionately more common in women of child-bearing age.  Although autosomal inheritance pattern of disease lead to an equal distribution of male patients and female patients, the disease has female predominance whose bleeding tendency shows during [[menstruation]]. There is no racial predilection to [[vWD]] however, it may be more severe or apparent in people with [[blood type]] O.


==Epidemiology and Demographics==
==Epidemiology and Demographics==
===Prevalence===
===Prevalence===
The prevalence of von Willebrand’s disease is 0.6 to 1.3%.<ref name="pmid18315614">{{cite journal| author=Nichols WL, Hultin MB, James AH, Manco-Johnson MJ, Montgomery RR, Ortel TL et al.| title=von Willebrand disease (VWD): evidence-based diagnosis and management guidelines, the National Heart, Lung, and Blood Institute (NHLBI) Expert Panel report (USA). | journal=Haemophilia | year= 2008 | volume= 14 | issue= 2 | pages= 171-232 | pmid=18315614 | doi=10.1111/j.1365-2516.2007.01643.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18315614  }} </ref><ref name="pmid3492222">{{cite journal| author=Rodeghiero F, Castaman G, Dini E| title=Epidemiological investigation of the prevalence of von Willebrand's disease. | journal=Blood | year= 1987 | volume= 69 | issue= 2 | pages= 454-9 | pmid=3492222 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=3492222  }} </ref>
The prevalence of von Willebrand’s disease is 0.6 to 1.3%.<ref name="pmid18315614">{{cite journal| author=Nichols WL, Hultin MB, James AH, Manco-Johnson MJ, Montgomery RR, Ortel TL et al.| title=von Willebrand disease (VWD): evidence-based diagnosis and management guidelines, the National Heart, Lung, and Blood Institute (NHLBI) Expert Panel report (USA). | journal=Haemophilia | year= 2008 | volume= 14 | issue= 2 | pages= 171-232 | pmid=18315614 | doi=10.1111/j.1365-2516.2007.01643.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18315614  }} </ref><ref name="pmid3492222">{{cite journal| author=Rodeghiero F, Castaman G, Dini E| title=Epidemiological investigation of the prevalence of von Willebrand's disease. | journal=Blood | year= 1987 | volume= 69 | issue= 2 | pages= 454-9 | pmid=3492222 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=3492222  }} </ref>
It is estimated that the referral prevalence of von Willebrand’s disease is approximately 1 case per 10,000 persons.  
It is estimated that the referral prevalence of von Willebrand’s disease is approximately 1 case per 10,000 persons.<ref name="pmid10959685">{{cite journal| author=Sadler JE, Mannucci PM, Berntorp E, Bochkov N, Boulyjenkov V, Ginsburg D et al.| title=Impact, diagnosis and treatment of von Willebrand disease. | journal=Thromb Haemost | year= 2000 | volume= 84 | issue= 2 | pages= 160-74 | pmid=10959685 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10959685  }} </ref>


The actual abnormality (which does not necessarily lead to disease) occurs in 0.9-3% of the population.
The actual abnormality (which does not necessarily lead to disease) occurs in 0.9-3% of the population.


===Age===
===Age===
 
The symptoms of VWD is disproportionately more common in women of child-bearing age.<ref name="pmid18315614">{{cite journal| author=Nichols WL, Hultin MB, James AH, Manco-Johnson MJ, Montgomery RR, Ortel TL et al.| title=von Willebrand disease (VWD): evidence-based diagnosis and management guidelines, the National Heart, Lung, and Blood Institute (NHLBI) Expert Panel report (USA). | journal=Haemophilia | year= 2008 | volume= 14 | issue= 2 | pages= 171-232 | pmid=18315614 | doi=10.1111/j.1365-2516.2007.01643.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18315614  }} </ref>


===Gender===
===Gender===
Although autosomal inheritance pattern of disease lead to an equal distribution of male patients and female patients, the disease has female predominance whose bleeding tendency shows during [[menstruation]].
Although autosomal inheritance pattern of disease lead to an equal distribution of male patients and female patients, the disease has female predominance whose bleeding tendency shows during [[menstruation]].<ref name="pmid10513768">{{cite journal| author=Lee CA| title=Women and inherited bleeding disorders: menstrual issues. | journal=Semin Hematol | year= 1999 | volume= 36 | issue= 3 Suppl 4 | pages= 21-7 | pmid=10513768 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10513768  }} </ref><ref name="pmid21040234">{{cite journal| author=Miller CH, Philipp CS, Stein SF, Kouides PA, Lukes AS, Heit JA et al.| title=The spectrum of haemostatic characteristics of women with unexplained menorrhagia. | journal=Haemophilia | year= 2011 | volume= 17 | issue= 1 | pages= e223-9 | pmid=21040234 | doi=10.1111/j.1365-2516.2010.02382.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21040234  }} </ref>


===Race===
===Race===
Line 28: Line 28:
{{WH}}
{{WH}}
{{WS}}
{{WS}}
[[Category:Disease]]
[[Category:Pediatrics]]
[[Category:Blood disorders]]
[[Category:Genetic disorders]]
[[Category:Hematology]]
[[Category:Mature chapter]]
[[Category:Needs content]]

Latest revision as of 17:12, 29 August 2018

Von Willebrand disease Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Von Willebrand disease from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Study of Choice

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

Chest X Ray

CT

MRI

Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Von Willebrand disease epidemiology and demographics On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Von Willebrand disease epidemiology and demographics

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Von Willebrand disease epidemiology and demographics

on Von Willebrand disease epidemiology and demographics

Von Willebrand disease epidemiology and demographics in the news

Blogs on Von Willebrand disease epidemiology and demographics

Directions to Hospitals Treating Von Willebrand disease

Risk calculators and risk factors for Von Willebrand disease epidemiology and demographics

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Prince Tano Djan, BSc, MBChB [2]

Overview

The prevalence of von Willebrand’s disease is 0.6 to 1.3%. It is estimated that the referral prevalence of von Willebrand’s disease is approximately 1 case per 10,000 persons. The actual abnormality (which does not necessarily lead to disease) occurs in 0.9-3% of the population. The symptoms of VWD is disproportionately more common in women of child-bearing age. Although autosomal inheritance pattern of disease lead to an equal distribution of male patients and female patients, the disease has female predominance whose bleeding tendency shows during menstruation. There is no racial predilection to vWD however, it may be more severe or apparent in people with blood type O.

Epidemiology and Demographics

Prevalence

The prevalence of von Willebrand’s disease is 0.6 to 1.3%.[1][2] It is estimated that the referral prevalence of von Willebrand’s disease is approximately 1 case per 10,000 persons.[3]

The actual abnormality (which does not necessarily lead to disease) occurs in 0.9-3% of the population.

Age

The symptoms of VWD is disproportionately more common in women of child-bearing age.[1]

Gender

Although autosomal inheritance pattern of disease lead to an equal distribution of male patients and female patients, the disease has female predominance whose bleeding tendency shows during menstruation.[4][5]

Race

There is no racial predilection to vWD however, it may be more severe or apparent in people with blood type O.[6]

References

  1. 1.0 1.1 Nichols WL, Hultin MB, James AH, Manco-Johnson MJ, Montgomery RR, Ortel TL; et al. (2008). "von Willebrand disease (VWD): evidence-based diagnosis and management guidelines, the National Heart, Lung, and Blood Institute (NHLBI) Expert Panel report (USA)". Haemophilia. 14 (2): 171–232. doi:10.1111/j.1365-2516.2007.01643.x. PMID 18315614.
  2. Rodeghiero F, Castaman G, Dini E (1987). "Epidemiological investigation of the prevalence of von Willebrand's disease". Blood. 69 (2): 454–9. PMID 3492222.
  3. Sadler JE, Mannucci PM, Berntorp E, Bochkov N, Boulyjenkov V, Ginsburg D; et al. (2000). "Impact, diagnosis and treatment of von Willebrand disease". Thromb Haemost. 84 (2): 160–74. PMID 10959685.
  4. Lee CA (1999). "Women and inherited bleeding disorders: menstrual issues". Semin Hematol. 36 (3 Suppl 4): 21–7. PMID 10513768.
  5. Miller CH, Philipp CS, Stein SF, Kouides PA, Lukes AS, Heit JA; et al. (2011). "The spectrum of haemostatic characteristics of women with unexplained menorrhagia". Haemophilia. 17 (1): e223–9. doi:10.1111/j.1365-2516.2010.02382.x. PMID 21040234.
  6. Gill JC, Endres-Brooks J, Bauer PJ, Marks WJ, Montgomery RR (1987). "The effect of ABO blood group on the diagnosis of von Willebrand disease". Blood. 69 (6): 1691–5. PMID 3495304.

Template:WH Template:WS