Vitiligo other diagnostic studies: Difference between revisions
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==Overview== | ==Overview== | ||
Although not performed routinely, since the [[diagnosis]] of [[vitiligo]] is often reached by a thorough history assessment and [[physical examination]], a [[biopsy]] of the [[lesion]] may show microscopical changes undergoing on the hypopigmented region. | |||
==Other Diagnosis Studies== | ==Other Diagnosis Studies== | ||
=== | ===Biopsy=== | ||
[[ | Frequently not required, since the [[diagnosis]] is often suggested by the history and characteristics of the [[lesions]]. However, an [[electron microscopy]] study of the [[skin]] [[lesions]] will show the previously mentioned [[Vitiligo pathophysiology#Microscopic Pathology|microscopical changes]], thereby confirming:<ref>{{cite book | last = Rook | first = Arthur | title = Rook's textbook of dermatology | publisher = Blackwell Science | location = Malden, Mass | year = 2004 | isbn = 0-632-06429-3 }}</ref><ref name="pmid5448375">{{cite journal| author=Dawber RP| title=Clinical associations of vitiligo. | journal=Postgrad Med J | year= 1970 | volume= 46 | issue= 535 | pages= 276-7 | pmid=5448375 | doi= | pmc=PMC2467025 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=5448375 }} </ref><ref name="BirbeckBreathnach1961">{{cite journal|last1=Birbeck|first1=Michael S|last2=Breathnach|first2=Aodán S|last3=Everall|first3=John D|title=An Electron Microscope Study of Basal Melanocytes and High-Level Clear Cells (Langerhans Cells) in Vitiligo1|journal=The Journal of Investigative Dermatology|volume=37|issue=1|year=1961|pages=51–64|issn=0022-202X|doi=10.1038/jid.1961.80}}</ref> | ||
*[[Melanocyte]] loss. | |||
*[[Melanocyte]] degeneration on the margins of the [[lesions]]. | |||
*[[Keratinocyte]] abnormalities. | |||
*Occasional [[dermal]] hypercellularity may be found. | |||
*In [[inflammatory]] vitiligo, the study of the [[cells]] from the [[erythematous]] margins will show the [[lymphocyte|lymphocitic]] infiltrates. | |||
==References== | ==References== | ||
Latest revision as of 19:23, 26 June 2014
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: João André Alves Silva, M.D. [2]
Overview
Although not performed routinely, since the diagnosis of vitiligo is often reached by a thorough history assessment and physical examination, a biopsy of the lesion may show microscopical changes undergoing on the hypopigmented region.
Other Diagnosis Studies
Biopsy
Frequently not required, since the diagnosis is often suggested by the history and characteristics of the lesions. However, an electron microscopy study of the skin lesions will show the previously mentioned microscopical changes, thereby confirming:[1][2][3]
- Melanocyte loss.
- Melanocyte degeneration on the margins of the lesions.
- Keratinocyte abnormalities.
- Occasional dermal hypercellularity may be found.
- In inflammatory vitiligo, the study of the cells from the erythematous margins will show the lymphocitic infiltrates.
References
- ↑ Rook, Arthur (2004). Rook's textbook of dermatology. Malden, Mass: Blackwell Science. ISBN 0-632-06429-3.
- ↑ Dawber RP (1970). "Clinical associations of vitiligo". Postgrad Med J. 46 (535): 276–7. PMC 2467025. PMID 5448375.
- ↑ Birbeck, Michael S; Breathnach, Aodán S; Everall, John D (1961). "An Electron Microscope Study of Basal Melanocytes and High-Level Clear Cells (Langerhans Cells) in Vitiligo1". The Journal of Investigative Dermatology. 37 (1): 51–64. doi:10.1038/jid.1961.80. ISSN 0022-202X.