Vitiligo causes: Difference between revisions
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(Created page with "__NOTOC__ {{Vitiligo}} {{CMG}} ==Overview== ==Causes== ==References== {{reflist|2}} Category:Dermatology Category:Autoimmune diseases [[Category:Pigment disorders]...") |
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==Overview== | ==Overview== | ||
Vitiligo is caused by a loss of skin [[melanocytes]]. Although the exact mechanism is not known, at least in some cases, an autoimmune process may play a role. <ref name="pmid12859615">{{cite journal| author=Gauthier Y, Cario Andre M, Taïeb A| title=A critical appraisal of vitiligo etiologic theories. Is melanocyte loss a melanocytorrhagy? | journal=Pigment Cell Res | year= 2003 | volume= 16 | issue= 4 | pages= 322-32 | pmid=12859615 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12859615 }} </ref><ref name="pmid16965269">{{cite journal| author=Dell'anna ML, Picardo M| title=A review and a new hypothesis for non-immunological pathogenetic mechanisms in vitiligo. | journal=Pigment Cell Res | year= 2006 | volume= 19 | issue= 5 | pages= 406-11 | pmid=16965269 | doi=10.1111/j.1600-0749.2006.00333.x | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16965269 }} </ref> The fact that vitiligo is more prevalent in patients with certain autoimmune disorders, such as [[Addison's disease]], [[hyperthyroidism]], [[alopecia areata]] and [[pernicious anemia]] supports this hypothesis,<ref>{{Cite journal | |||
| author = [[Shahla Babaee Nejad]], [[Hamideh Herizchi Qadim]], [[Leila Nazeman]], [[Roohollah Fadaii]] & [[Mohamad Goldust]] | |||
| title = Frequency of autoimmune diseases in those suffering from vitiligo in comparison with normal population | |||
| journal = [[Pakistan journal of biological sciences: PJBS]] | |||
| volume = 16 | |||
| issue = 12 | |||
| pages = 570–574 | |||
| year = 2013 | |||
| month = June | |||
| pmid = 24494526 | |||
}}</ref><ref>{{Cite journal | |||
| author = [[Daniel Holthausen Nunes]] & [[Ligia Maria Hademann Esser]] | |||
| title = Vitiligo epidemiological profile and the association with thyroid disease | |||
| journal = [[Anais brasileiros de dermatologia]] | |||
| volume = 86 | |||
| issue = 2 | |||
| pages = 241–248 | |||
| year = 2011 | |||
| month = March-April | |||
| pmid = 21603806 | |||
}}</ref><ref>{{Cite journal | |||
| author = [[Kirsty J. MacLean]] & [[Michael J. Tidman]] | |||
| title = Alopecia areata: more than skin deep | |||
| journal = [[The Practitioner]] | |||
| volume = 257 | |||
| issue = 1764 | |||
| pages = 29–32 | |||
| year = 2013 | |||
| month = September | |||
| pmid = 24383154 | |||
}}</ref> but it should also be recognized that the majority of patients with vitiligo do not have any autoimmune disorder. | |||
==Causes== | ==Causes== | ||
Revision as of 20:50, 25 June 2014
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Vitiligo is caused by a loss of skin melanocytes. Although the exact mechanism is not known, at least in some cases, an autoimmune process may play a role. [1][2] The fact that vitiligo is more prevalent in patients with certain autoimmune disorders, such as Addison's disease, hyperthyroidism, alopecia areata and pernicious anemia supports this hypothesis,[3][4][5] but it should also be recognized that the majority of patients with vitiligo do not have any autoimmune disorder.
Causes
References
- ↑ Gauthier Y, Cario Andre M, Taïeb A (2003). "A critical appraisal of vitiligo etiologic theories. Is melanocyte loss a melanocytorrhagy?". Pigment Cell Res. 16 (4): 322–32. PMID 12859615.
- ↑ Dell'anna ML, Picardo M (2006). "A review and a new hypothesis for non-immunological pathogenetic mechanisms in vitiligo". Pigment Cell Res. 19 (5): 406–11. doi:10.1111/j.1600-0749.2006.00333.x. PMID 16965269.
- ↑ Shahla Babaee Nejad, Hamideh Herizchi Qadim, Leila Nazeman, Roohollah Fadaii & Mohamad Goldust (2013). "Frequency of autoimmune diseases in those suffering from vitiligo in comparison with normal population". Pakistan journal of biological sciences: PJBS. 16 (12): 570–574. PMID 24494526. Unknown parameter
|month=ignored (help) - ↑ Daniel Holthausen Nunes & Ligia Maria Hademann Esser (2011). "Vitiligo epidemiological profile and the association with thyroid disease". Anais brasileiros de dermatologia. 86 (2): 241–248. PMID 21603806. Unknown parameter
|month=ignored (help) - ↑ Kirsty J. MacLean & Michael J. Tidman (2013). "Alopecia areata: more than skin deep". The Practitioner. 257 (1764): 29–32. PMID 24383154. Unknown parameter
|month=ignored (help)