Ventricular septal defect genetics

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] and Leida Perez, M.D.

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Genetics

The frequent association between arch abnormalities and significant conal VSDs suggests a common mechanism involving a chromosome band 22q11 microdeletion. Deletions in this area have not been linked with isolated supracristal VSDs.