VPS4A

Vacuolar protein sorting 4 homolog A (S. cerevisiae)
File:PBB Protein VPS4A image.jpg PDB rendering based on 1yxr.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1yxr​
Identifiers
Symbols	VPS4A ; SKD2; SKD1; FLJ22197; VPS4; VPS4-1
External IDs	Template:OMIM5 Template:MGI HomoloGene: 69132
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE VPS4A 217913 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Vacuolar protein sorting 4 homolog A (S. cerevisiae), also known as VPS4A, is a human gene.

The protein encoded by this gene is a member of the AAA protein family (ATPases associated with diverse cellular activities), and is the homolog of the yeast Vps4 protein. In humans, two paralogs of the yeast protein have been identified. The former share a high degree of aa sequence similarity with each other, and also with yeast Vps4 and mouse Skd1 proteins. The mouse Skd1 (suppressor of K+ transport defect 1) has been shown to be really a yeast Vps4 ortholog. Functional studies indicate that both human paralogs associate with the endosomal compartments, and are involved in intracellular protein trafficking, similar to Vps4 protein in yeast. The gene encoding this paralog has been mapped to chromosome 16; the gene for the other resides on chromosome 18.

Further reading

• Scheuring S, Bodor O, Röhricht RA; et al. (1999). "Cloning, characterisation, and functional expression of the Mus musculus SKD1 gene in yeast demonstrates that the mouse SKD1 and the yeast VPS4 genes are orthologues and involved in intracellular protein trafficking". Gene. 234 (1): 149–59. PMID 10393249.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bishop N, Woodman P (2000). "ATPase-defective mammalian VPS4 localizes to aberrant endosomes and impairs cholesterol trafficking". Mol. Biol. Cell. 11 (1): 227–39. PMID 10637304.
• Hu RM, Han ZG, Song HD; et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. doi:10.1073/pnas.160270997. PMID 10931946.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Howard TL, Stauffer DR, Degnin CR, Hollenberg SM (2002). "CHMP1 functions as a member of a newly defined family of vesicle trafficking proteins". J. Cell. Sci. 114 (Pt 13): 2395–404. PMID 11559748.CS1 maint: Multiple names: authors list (link)
• Scheuring S, Röhricht RA, Schöning-Burkhardt B; et al. (2001). "Mammalian cells express two VPS4 proteins both of which are involved in intracellular protein trafficking". J. Mol. Biol. 312 (3): 469–80. doi:10.1006/jmbi.2001.4917. PMID 11563910.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tanaka H, Fujita H, Katoh H; et al. (2002). "Vps4-A (vacuolar protein sorting 4-A) is a binding partner for a novel Rho family GTPase, Rnd2". Biochem. J. 365 (Pt 2): 349–53. doi:10.1042/BJ20020062. PMID 11931639.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nara A, Mizushima N, Yamamoto A; et al. (2002). "SKD1 AAA ATPase-dependent endosomal transport is involved in autolysosome formation". Cell Struct. Funct. 27 (1): 29–37. PMID 11937716.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chagnon P, Michaud J, Mitchell G; et al. (2003). "A missense mutation (R565W) in cirhin (FLJ14728) in North American Indian childhood cirrhosis". Am. J. Hum. Genet. 71 (6): 1443–9. PMID 12417987.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Beyer A, Scheuring S, Müller S; et al. (2003). "Comparative sequence and expression analyses of four mammalian VPS4 genes". Gene. 305 (1): 47–59. PMID 12594041.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Katoh K, Shibata H, Suzuki H; et al. (2003). "The ALG-2-interacting protein Alix associates with CHMP4b, a human homologue of yeast Snf7 that is involved in multivesicular body sorting". J. Biol. Chem. 278 (40): 39104–13. doi:10.1074/jbc. M301604200 . PMID 12860994.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strack B, Calistri A, Craig S; et al. (2003). "AIP1/ALIX is a binding partner for HIV-1 p6 and EIAV p9 functioning in virus budding". Cell. 114 (6): 689–99. PMID 14505569.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• von Schwedler UK, Stuchell M, Müller B; et al. (2003). "The protein network of HIV budding". Cell. 114 (6): 701–13. PMID 14505570.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sachse M, Strous GJ, Klumperman J (2004). "ATPase-deficient hVPS4 impairs formation of internal endosomal vesicles and stabilizes bilayered clathrin coats on endosomal vacuoles". J. Cell. Sci. 117 (Pt 9): 1699–708. doi:10.1242/jcs.00998. PMID 15075231.CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lin Y, Kimpler LA, Naismith TV; et al. (2005). "Interaction of the mammalian endosomal sorting complex required for transport (ESCRT) III protein hSnf7-1 with itself, membranes, and the AAA+ ATPase SKD1". J. Biol. Chem. 280 (13): 12799–809. doi:10.1074/jbc. M413968200 . PMID 15632132.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Scott A, Gaspar J, Stuchell-Brereton MD; et al. (2005). "Structure and ESCRT-III protein interactions of the MIT domain of human VPS4A". Proc. Natl. Acad. Sci. U.S.A. 102 (39): 13813–8. doi:10.1073/pnas.0502165102. PMID 16174732.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tsang HT, Connell JW, Brown SE; et al. (2006). "A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex". Genomics. 88 (3): 333–46. doi:10.1016/j.ygeno.2006.04.003. PMID 16730941.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chen VY, Posada MM, Blazer LL; et al. (2007). "The role of the VPS4A-exosome pathway in the intrinsic egress route of a DNA-binding anticancer drug". Pharm. Res. 23 (8): 1687–95. doi:10.1007/s11095-006-9043-0. PMID 16841193.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lambert C, Döring T, Prange R (2007). "Hepatitis B virus maturation is sensitive to functional inhibition of ESCRT-III, Vps4, and gamma 2-adaptin". J. Virol. 81 (17): 9050–60. doi:10.1128/JVI.00479-07. PMID 17553870.CS1 maint: Multiple names: authors list (link)