VPS4A: Difference between revisions

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Latest revision as of 22:36, 8 November 2017

Vacuolar protein sorting-associated protein 4A is a protein that in humans is encoded by the VPS4A gene.^[1]^[2]^[3]

Function

The protein encoded by this gene is a member of the AAA protein family (ATPases associated with diverse cellular activities), and is the homolog of the yeast Vps4 protein. In humans, two paralogs of the yeast protein have been identified. The former share a high degree of aa sequence similarity with each other, and also with yeast Vps4 and mouse Skd1 proteins. The mouse Skd1 (suppressor of K+ transport defect 1) has been shown to be really a yeast Vps4 ortholog. Functional studies indicate that both human paralogs associate with the endosomal compartments, and are involved in intracellular protein trafficking, similar to Vps4 protein in yeast. The gene encoding this paralog has been mapped to chromosome 16; the gene for the other resides on chromosome 18.^[3]

Interactions

VPS4A has been shown to interact with CHMP1A.^[4]

References

↑ Bishop N, Woodman P (April 2000). "ATPase-defective Mammalian VPS4 Localizes to Aberrant Endosomes and Impairs Cholesterol Trafficking". Mol Biol Cell. 11 (1): 227–39. doi:10.1091/mbc.11.1.227. PMC 14770. PMID 10637304.
↑ Scheuring S, Röhricht RA, Schöning-Burkhardt B, Beyer A, Müller S, Abts HF, Köhrer K (September 2001). "Mammalian cells express two VPS4 proteins both of which are involved in intracellular protein trafficking". J Mol Biol. 312 (3): 469–80. doi:10.1006/jmbi.2001.4917. PMID 11563910.
↑ ^3.0 ^3.1 "Entrez Gene: VPS4A vacuolar protein sorting 4 homolog A (S. cerevisiae)".
↑ Howard TL, Stauffer DR, Degnin CR, Hollenberg SM (July 2001). "CHMP1 functions as a member of a newly defined family of vesicle trafficking proteins". J. Cell Sci. 114 (Pt 13): 2395–404. PMID 11559748.

Scheuring S, Bodor O, Röhricht RA, Müller S, Beyer A, Köhrer K (1999). "Cloning, characterisation, and functional expression of the Mus musculus SKD1 gene in yeast demonstrates that the mouse SKD1 and the yeast VPS4 genes are orthologues and involved in intracellular protein trafficking". Gene. 234 (1): 149–59. doi:10.1016/S0378-1119(99)00163-8. PMID 10393249.
Hu RM, Han ZG, Song HD, Peng YD, Huang QH, Ren SX, Gu YJ, Huang CH, Li YB, Jiang CL, Fu G, Zhang QH, Gu BW, Dai M, Mao YF, Gao GF, Rong R, Ye M, Zhou J, Xu SH, Gu J, Shi JX, Jin WR, Zhang CK, Wu TM, Huang GY, Chen Z, Chen MD, Chen JL (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. doi:10.1073/pnas.160270997. PMC 16901. PMID 10931946.
Howard TL, Stauffer DR, Degnin CR, Hollenberg SM (2002). "CHMP1 functions as a member of a newly defined family of vesicle trafficking proteins". J. Cell Sci. 114 (Pt 13): 2395–404. PMID 11559748.
Tanaka H, Fujita H, Katoh H, Mori K, Negishi M (2002). "Vps4-A (vacuolar protein sorting 4-A) is a binding partner for a novel Rho family GTPase, Rnd2". Biochem. J. 365 (Pt 2): 349–53. doi:10.1042/BJ20020062. PMC 1222680. PMID 11931639.
Nara A, Mizushima N, Yamamoto A, Kabeya Y, Ohsumi Y, Yoshimori T (2002). "SKD1 AAA ATPase-dependent endosomal transport is involved in autolysosome formation". Cell Struct. Funct. 27 (1): 29–37. doi:10.1247/csf.27.29. PMID 11937716.
Chagnon P, Michaud J, Mitchell G, Mercier J, Marion JF, Drouin E, Rasquin-Weber A, Hudson TJ, Richter A (2003). "A Missense Mutation (R565W) in Cirhin (FLJ14728) in North American Indian Childhood Cirrhosis". Am. J. Hum. Genet. 71 (6): 1443–9. doi:10.1086/344580. PMC 378590. PMID 12417987.
Beyer A, Scheuring S, Müller S, Mincheva A, Lichter P, Köhrer K (2003). "Comparative sequence and expression analyses of four mammalian VPS4 genes". Gene. 305 (1): 47–59. doi:10.1016/S0378-1119(02)01205-2. PMID 12594041.
Katoh K, Shibata H, Suzuki H, Nara A, Ishidoh K, Kominami E, Yoshimori T, Maki M (2003). "The ALG-2-interacting protein Alix associates with CHMP4b, a human homologue of yeast Snf7 that is involved in multivesicular body sorting". J. Biol. Chem. 278 (40): 39104–13. doi:10.1074/jbc.M301604200. PMID 12860994.
Strack B, Calistri A, Craig S, Popova E, Göttlinger HG (2003). "AIP1/ALIX is a binding partner for HIV-1 p6 and EIAV p9 functioning in virus budding". Cell. 114 (6): 689–99. doi:10.1016/S0092-8674(03)00653-6. PMID 14505569.
von Schwedler UK, Stuchell M, Müller B, Ward DM, Chung HY, Morita E, Wang HE, Davis T, He GP, Cimbora DM, Scott A, Kräusslich HG, Kaplan J, Morham SG, Sundquist WI (2003). "The protein network of HIV budding". Cell. 114 (6): 701–13. doi:10.1016/S0092-8674(03)00714-1. PMID 14505570.
Sachse M, Strous GJ, Klumperman J (2004). "ATPase-deficient hVPS4 impairs formation of internal endosomal vesicles and stabilizes bilayered clathrin coats on endosomal vacuoles". J. Cell Sci. 117 (Pt 9): 1699–708. doi:10.1242/jcs.00998. PMID 15075231.
Lin Y, Kimpler LA, Naismith TV, Lauer JM, Hanson PI (2005). "Interaction of the mammalian endosomal sorting complex required for transport (ESCRT) III protein hSnf7-1 with itself, membranes, and the AAA+ ATPase SKD1". J. Biol. Chem. 280 (13): 12799–809. doi:10.1074/jbc.M413968200. PMID 15632132.
Scott A, Gaspar J, Stuchell-Brereton MD, Alam SL, Skalicky JJ, Sundquist WI (2005). "Structure and ESCRT-III protein interactions of the MIT domain of human VPS4A". Proc. Natl. Acad. Sci. U.S.A. 102 (39): 13813–8. doi:10.1073/pnas.0502165102. PMC 1236530. PMID 16174732.
Tsang HT, Connell JW, Brown SE, Thompson A, Reid E, Sanderson CM (2006). "A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex". Genomics. 88 (3): 333–46. doi:10.1016/j.ygeno.2006.04.003. PMID 16730941.
Chen VY, Posada MM, Blazer LL, Zhao T, Rosania GR (2007). "The role of the VPS4A-exosome pathway in the intrinsic egress route of a DNA-binding anticancer drug". Pharm. Res. 23 (8): 1687–95. doi:10.1007/s11095-006-9043-0. PMID 16841193.
Lambert C, Döring T, Prange R (2007). "Hepatitis B Virus Maturation Is Sensitive to Functional Inhibition of ESCRT-III, Vps4, and γ2-Adaptin". J. Virol. 81 (17): 9050–60. doi:10.1128/JVI.00479-07. PMC 1951427. PMID 17553870.

This article on a gene on human chromosome 16 is a stub. You can help Wikipedia by expanding it.

[pmid10637304-1] Bishop N, Woodman P (April 2000). "ATPase-defective Mammalian VPS4 Localizes to Aberrant Endosomes and Impairs Cholesterol Trafficking". Mol Biol Cell. 11 (1): 227–39. doi:10.1091/mbc.11.1.227. PMC 14770. PMID 10637304.

[pmid11563910-2] Scheuring S, Röhricht RA, Schöning-Burkhardt B, Beyer A, Müller S, Abts HF, Köhrer K (September 2001). "Mammalian cells express two VPS4 proteins both of which are involved in intracellular protein trafficking". J Mol Biol. 312 (3): 469–80. doi:10.1006/jmbi.2001.4917. PMID 11563910.

[entrez-3] 3.0 ^3.1 "Entrez Gene: VPS4A vacuolar protein sorting 4 homolog A (S. cerevisiae)".

[pmid11559748-4] Howard TL, Stauffer DR, Degnin CR, Hollenberg SM (July 2001). "CHMP1 functions as a member of a newly defined family of vesicle trafficking proteins". J. Cell Sci. 114 (Pt 13): 2395–404. PMID 11559748.

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@@ Line 1: / Line 1: @@
-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{Infobox_gene}}
-{{PBB_Controls
+'''Vacuolar protein sorting-associated protein 4A''' is a [[protein]] that in humans is encoded by the ''VPS4A'' [[gene]].<ref name="pmid10637304">{{cite journal | vauthors = Bishop N, Woodman P | title = ATPase-defective Mammalian VPS4 Localizes to Aberrant Endosomes and Impairs Cholesterol Trafficking | journal = Mol Biol Cell | volume = 11 | issue = 1 | pages = 227–39 | date = April 2000 | pmid = 10637304 | pmc = 14770 | doi = 10.1091/mbc.11.1.227 }}</ref><ref name="pmid11563910">{{cite journal | vauthors = Scheuring S, Röhricht RA, Schöning-Burkhardt B, Beyer A, Müller S, Abts HF, Köhrer K | title = Mammalian cells express two VPS4 proteins both of which are involved in intracellular protein trafficking | journal = J Mol Biol | volume = 312 | issue = 3 | pages = 469–80 | date = September 2001 | pmid = 11563910 | pmc =  | doi = 10.1006/jmbi.2001.4917 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: VPS4A vacuolar protein sorting 4 homolog A (S. cerevisiae)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27183| accessdate = }}</ref>
-| update_page = yes
-| require_manual_inspection = no
-| update_protein_box = yes
-| update_summary = yes
-| update_citations = yes
-}}
-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+== Function ==
-{{GNF_Protein_box
- | image = PBB_Protein_VPS4A_image.jpg
- | image_source = [[Protein Data Bank|PDB]] rendering based on 1yxr.
- | PDB = {{PDB2|1yxr}}
- | Name = Vacuolar protein sorting 4 homolog A (S. cerevisiae)
- | HGNCid = 13488
- | Symbol = VPS4A
- | AltSymbols =; SKD2; SKD1; FLJ22197; VPS4; VPS4-1
- | OMIM = 609982
- | ECnumber =
- | Homologene = 69132
- | MGIid = 1890520
- | GeneAtlas_image1 = PBB_GE_VPS4A_217913_at_tn.png
- | Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0017111 |text = nucleoside-triphosphatase activity}}
- | Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005773 |text = vacuole}} {{GNF_GO|id=GO:0005829 |text = cytosol}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0048471 |text = perinuclear region of cytoplasm}}
- | Process = {{GNF_GO|id=GO:0015031 |text = protein transport}} {{GNF_GO|id=GO:0016192 |text = vesicle-mediated transport}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 27183
-    | Hs_Ensembl = ENSG00000132612
-    | Hs_RefseqProtein = NP_037377
-    | Hs_RefseqmRNA = NM_013245
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 16
-    | Hs_GenLoc_start = 67907407
-    | Hs_GenLoc_end = 67915718
-    | Hs_Uniprot = Q9UN37
-    | Mm_EntrezGene = 116733
-    | Mm_Ensembl = ENSMUSG00000031913
-    | Mm_RefseqmRNA = NM_126165
-    | Mm_RefseqProtein = NP_569053
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 8
-    | Mm_GenLoc_start = 109925745
-    | Mm_GenLoc_end = 109934885
-    | Mm_Uniprot = Q3TDX2
-  }}
-}}
-'''Vacuolar protein sorting 4 homolog A (S. cerevisiae)''', also known as '''VPS4A''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: VPS4A vacuolar protein sorting 4 homolog A (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27183| accessdate = }}</ref>
-<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+The protein encoded by this gene is a member of the AAA protein family (ATPases associated with diverse cellular activities), and is the homolog of the yeast Vps4 protein. In humans, two paralogs of the yeast protein have been identified. The former share a high degree of aa sequence similarity with each other, and also with yeast Vps4 and mouse Skd1 proteins. The mouse Skd1 (suppressor of K+ transport defect 1) has been shown to be really a yeast Vps4 ortholog. Functional studies indicate that both human paralogs associate with the endosomal compartments, and are involved in intracellular protein trafficking, similar to Vps4 protein in yeast. The gene encoding this paralog has been mapped to chromosome 16; the gene for the other resides on chromosome 18.<ref name="entrez"/>
-{{PBB_Summary
-| section_title =
-| summary_text = The protein encoded by this gene is a member of the AAA protein family (ATPases associated with diverse cellular activities), and is the homolog of the yeast Vps4 protein. In humans, two paralogs of the yeast protein have been identified. The former share a high degree of aa sequence similarity with each other, and also with yeast Vps4 and mouse Skd1 proteins. The mouse Skd1 (suppressor of K+ transport defect 1) has been shown to be really a yeast Vps4 ortholog. Functional studies indicate that both human paralogs associate with the endosomal compartments, and are involved in intracellular protein trafficking, similar to Vps4 protein in yeast. The gene encoding this paralog has been mapped to chromosome 16; the gene for the other resides on chromosome 18.<ref name="entrez">{{cite web | title = Entrez Gene: VPS4A vacuolar protein sorting 4 homolog A (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27183| accessdate = }}</ref>
-}}
-==References==
+== Interactions ==
-{{reflist|2}}
-==Further reading==
-{{refbegin | 2}}
-{{PBB_Further_reading
-| citations =
-*{{cite journal  | author=Scheuring S, Bodor O, Röhricht RA, ''et al.'' |title=Cloning, characterisation, and functional expression of the Mus musculus SKD1 gene in yeast demonstrates that the mouse SKD1 and the yeast VPS4 genes are orthologues and involved in intracellular protein trafficking. |journal=Gene |volume=234 |issue= 1 |pages= 149-59 |year= 1999 |pmid= 10393249 |doi=  }}
-*{{cite journal  | author=Bishop N, Woodman P |title=ATPase-defective mammalian VPS4 localizes to aberrant endosomes and impairs cholesterol trafficking. |journal=Mol. Biol. Cell |volume=11 |issue= 1 |pages= 227-39 |year= 2000 |pmid= 10637304 |doi=  }}
-*{{cite journal  | author=Hu RM, Han ZG, Song HD, ''et al.'' |title=Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 17 |pages= 9543-8 |year= 2000 |pmid= 10931946 |doi= 10.1073/pnas.160270997 }}
-*{{cite journal  | author=Howard TL, Stauffer DR, Degnin CR, Hollenberg SM |title=CHMP1 functions as a member of a newly defined family of vesicle trafficking proteins. |journal=J. Cell. Sci. |volume=114 |issue= Pt 13 |pages= 2395-404 |year= 2002 |pmid= 11559748 |doi=  }}
-*{{cite journal  | author=Scheuring S, Röhricht RA, Schöning-Burkhardt B, ''et al.'' |title=Mammalian cells express two VPS4 proteins both of which are involved in intracellular protein trafficking. |journal=J. Mol. Biol. |volume=312 |issue= 3 |pages= 469-80 |year= 2001 |pmid= 11563910 |doi= 10.1006/jmbi.2001.4917 }}
-*{{cite journal  | author=Tanaka H, Fujita H, Katoh H, ''et al.'' |title=Vps4-A (vacuolar protein sorting 4-A) is a binding partner for a novel Rho family GTPase, Rnd2. |journal=Biochem. J. |volume=365 |issue= Pt 2 |pages= 349-53 |year= 2002 |pmid= 11931639 |doi= 10.1042/BJ20020062 }}
-*{{cite journal  | author=Nara A, Mizushima N, Yamamoto A, ''et al.'' |title=SKD1 AAA ATPase-dependent endosomal transport is involved in autolysosome formation. |journal=Cell Struct. Funct. |volume=27 |issue= 1 |pages= 29-37 |year= 2002 |pmid= 11937716 |doi=  }}
-*{{cite journal  | author=Chagnon P, Michaud J, Mitchell G, ''et al.'' |title=A missense mutation (R565W) in cirhin (FLJ14728) in North American Indian childhood cirrhosis. |journal=Am. J. Hum. Genet. |volume=71 |issue= 6 |pages= 1443-9 |year= 2003 |pmid= 12417987 |doi=  }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
-*{{cite journal  | author=Beyer A, Scheuring S, Müller S, ''et al.'' |title=Comparative sequence and expression analyses of four mammalian VPS4 genes. |journal=Gene |volume=305 |issue= 1 |pages= 47-59 |year= 2003 |pmid= 12594041 |doi=  }}
-*{{cite journal  | author=Katoh K, Shibata H, Suzuki H, ''et al.'' |title=The ALG-2-interacting protein Alix associates with CHMP4b, a human homologue of yeast Snf7 that is involved in multivesicular body sorting. |journal=J. Biol. Chem. |volume=278 |issue= 40 |pages= 39104-13 |year= 2003 |pmid= 12860994 |doi= 10.1074/jbc. M301604200 }}
-*{{cite journal  | author=Strack B, Calistri A, Craig S, ''et al.'' |title=AIP1/ALIX is a binding partner for HIV-1 p6 and EIAV p9 functioning in virus budding. |journal=Cell |volume=114 |issue= 6 |pages= 689-99 |year= 2003 |pmid= 14505569 |doi=  }}
-*{{cite journal  | author=von Schwedler UK, Stuchell M, Müller B, ''et al.'' |title=The protein network of HIV budding. |journal=Cell |volume=114 |issue= 6 |pages= 701-13 |year= 2003 |pmid= 14505570 |doi=  }}
-*{{cite journal  | author=Sachse M, Strous GJ, Klumperman J |title=ATPase-deficient hVPS4 impairs formation of internal endosomal vesicles and stabilizes bilayered clathrin coats on endosomal vacuoles. |journal=J. Cell. Sci. |volume=117 |issue= Pt 9 |pages= 1699-708 |year= 2004 |pmid= 15075231 |doi= 10.1242/jcs.00998 }}
-*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
-*{{cite journal  | author=Lin Y, Kimpler LA, Naismith TV, ''et al.'' |title=Interaction of the mammalian endosomal sorting complex required for transport (ESCRT) III protein hSnf7-1 with itself, membranes, and the AAA+ ATPase SKD1. |journal=J. Biol. Chem. |volume=280 |issue= 13 |pages= 12799-809 |year= 2005 |pmid= 15632132 |doi= 10.1074/jbc. M413968200 }}
-*{{cite journal  | author=Scott A, Gaspar J, Stuchell-Brereton MD, ''et al.'' |title=Structure and ESCRT-III protein interactions of the MIT domain of human VPS4A. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=102 |issue= 39 |pages= 13813-8 |year= 2005 |pmid= 16174732 |doi= 10.1073/pnas.0502165102 }}
-*{{cite journal  | author=Tsang HT, Connell JW, Brown SE, ''et al.'' |title=A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex. |journal=Genomics |volume=88 |issue= 3 |pages= 333-46 |year= 2006 |pmid= 16730941 |doi= 10.1016/j.ygeno.2006.04.003 }}
-*{{cite journal  | author=Chen VY, Posada MM, Blazer LL, ''et al.'' |title=The role of the VPS4A-exosome pathway in the intrinsic egress route of a DNA-binding anticancer drug. |journal=Pharm. Res. |volume=23 |issue= 8 |pages= 1687-95 |year= 2007 |pmid= 16841193 |doi= 10.1007/s11095-006-9043-0 }}
-*{{cite journal  | author=Lambert C, Döring T, Prange R |title=Hepatitis B virus maturation is sensitive to functional inhibition of ESCRT-III, Vps4, and gamma 2-adaptin. |journal=J. Virol. |volume=81 |issue= 17 |pages= 9050-60 |year= 2007 |pmid= 17553870 |doi= 10.1128/JVI.00479-07 }}
-}}
-{{refend}}
-{{protein-stub}}
+VPS4A has been shown to [[Protein-protein interaction|interact]] with [[CHMP1A]].<ref name=pmid11559748>{{cite journal | vauthors = Howard TL, Stauffer DR, Degnin CR, Hollenberg SM | title = CHMP1 functions as a member of a newly defined family of vesicle trafficking proteins | journal = J. Cell Sci. | volume = 114 | issue = Pt 13 | pages = 2395–404 | date = July 2001 | pmid = 11559748 }}</ref>
-{{WikiDoc Sources}}
+== References ==
+{{Reflist}}
+== Further reading ==
+{{Refbegin | 2}}
+* {{cite journal | vauthors = Scheuring S, Bodor O, Röhricht RA, Müller S, Beyer A, Köhrer K | title = Cloning, characterisation, and functional expression of the Mus musculus SKD1 gene in yeast demonstrates that the mouse SKD1 and the yeast VPS4 genes are orthologues and involved in intracellular protein trafficking | journal = Gene | volume = 234 | issue = 1 | pages = 149–59 | year = 1999 | pmid = 10393249 | doi = 10.1016/S0378-1119(99)00163-8 }}
+* {{cite journal | vauthors = Hu RM, Han ZG, Song HD, Peng YD, Huang QH, Ren SX, Gu YJ, Huang CH, Li YB, Jiang CL, Fu G, Zhang QH, Gu BW, Dai M, Mao YF, Gao GF, Rong R, Ye M, Zhou J, Xu SH, Gu J, Shi JX, Jin WR, Zhang CK, Wu TM, Huang GY, Chen Z, Chen MD, Chen JL | title = Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 97 | issue = 17 | pages = 9543–8 | year = 2000 | pmid = 10931946 | pmc = 16901 | doi = 10.1073/pnas.160270997 }}
+* {{cite journal | vauthors = Howard TL, Stauffer DR, Degnin CR, Hollenberg SM | title = CHMP1 functions as a member of a newly defined family of vesicle trafficking proteins | journal = J. Cell Sci. | volume = 114 | issue = Pt 13 | pages = 2395–404 | year = 2002 | pmid = 11559748 | doi =  }}
+* {{cite journal | vauthors = Tanaka H, Fujita H, Katoh H, Mori K, Negishi M | title = Vps4-A (vacuolar protein sorting 4-A) is a binding partner for a novel Rho family GTPase, Rnd2 | journal = Biochem. J. | volume = 365 | issue = Pt 2 | pages = 349–53 | year = 2002 | pmid = 11931639 | pmc = 1222680 | doi = 10.1042/BJ20020062 }}
+* {{cite journal | vauthors = Nara A, Mizushima N, Yamamoto A, Kabeya Y, Ohsumi Y, Yoshimori T | title = SKD1 AAA ATPase-dependent endosomal transport is involved in autolysosome formation | journal = Cell Struct. Funct. | volume = 27 | issue = 1 | pages = 29–37 | year = 2002 | pmid = 11937716 | doi = 10.1247/csf.27.29 }}
+* {{cite journal | vauthors = Chagnon P, Michaud J, Mitchell G, Mercier J, Marion JF, Drouin E, Rasquin-Weber A, Hudson TJ, Richter A | title = A Missense Mutation (R565W) in Cirhin (FLJ14728) in North American Indian Childhood Cirrhosis | journal = Am. J. Hum. Genet. | volume = 71 | issue = 6 | pages = 1443–9 | year = 2003 | pmid = 12417987 | pmc = 378590 | doi = 10.1086/344580 }}
+* {{cite journal | vauthors = Beyer A, Scheuring S, Müller S, Mincheva A, Lichter P, Köhrer K | title = Comparative sequence and expression analyses of four mammalian VPS4 genes | journal = Gene | volume = 305 | issue = 1 | pages = 47–59 | year = 2003 | pmid = 12594041 | doi = 10.1016/S0378-1119(02)01205-2 }}
+* {{cite journal | vauthors = Katoh K, Shibata H, Suzuki H, Nara A, Ishidoh K, Kominami E, Yoshimori T, Maki M | title = The ALG-2-interacting protein Alix associates with CHMP4b, a human homologue of yeast Snf7 that is involved in multivesicular body sorting | journal = J. Biol. Chem. | volume = 278 | issue = 40 | pages = 39104–13 | year = 2003 | pmid = 12860994 | doi = 10.1074/jbc.M301604200 }}
+* {{cite journal | vauthors = Strack B, Calistri A, Craig S, Popova E, Göttlinger HG | title = AIP1/ALIX is a binding partner for HIV-1 p6 and EIAV p9 functioning in virus budding | journal = Cell | volume = 114 | issue = 6 | pages = 689–99 | year = 2003 | pmid = 14505569 | doi = 10.1016/S0092-8674(03)00653-6 }}
+* {{cite journal | vauthors = von Schwedler UK, Stuchell M, Müller B, Ward DM, Chung HY, Morita E, Wang HE, Davis T, He GP, Cimbora DM, Scott A, Kräusslich HG, Kaplan J, Morham SG, Sundquist WI | title = The protein network of HIV budding | journal = Cell | volume = 114 | issue = 6 | pages = 701–13 | year = 2003 | pmid = 14505570 | doi = 10.1016/S0092-8674(03)00714-1 }}
+* {{cite journal | vauthors = Sachse M, Strous GJ, Klumperman J | title = ATPase-deficient hVPS4 impairs formation of internal endosomal vesicles and stabilizes bilayered clathrin coats on endosomal vacuoles | journal = J. Cell Sci. | volume = 117 | issue = Pt 9 | pages = 1699–708 | year = 2004 | pmid = 15075231 | doi = 10.1242/jcs.00998 }}
+* {{cite journal | vauthors = Lin Y, Kimpler LA, Naismith TV, Lauer JM, Hanson PI | title = Interaction of the mammalian endosomal sorting complex required for transport (ESCRT) III protein hSnf7-1 with itself, membranes, and the AAA+ ATPase SKD1 | journal = J. Biol. Chem. | volume = 280 | issue = 13 | pages = 12799–809 | year = 2005 | pmid = 15632132 | doi = 10.1074/jbc.M413968200 }}
+* {{cite journal | vauthors = Scott A, Gaspar J, Stuchell-Brereton MD, Alam SL, Skalicky JJ, Sundquist WI | title = Structure and ESCRT-III protein interactions of the MIT domain of human VPS4A | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 102 | issue = 39 | pages = 13813–8 | year = 2005 | pmid = 16174732 | pmc = 1236530 | doi = 10.1073/pnas.0502165102 }}
+* {{cite journal | vauthors = Tsang HT, Connell JW, Brown SE, Thompson A, Reid E, Sanderson CM | title = A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex | journal = Genomics | volume = 88 | issue = 3 | pages = 333–46 | year = 2006 | pmid = 16730941 | doi = 10.1016/j.ygeno.2006.04.003 }}
+* {{cite journal | vauthors = Chen VY, Posada MM, Blazer LL, Zhao T, Rosania GR | title = The role of the VPS4A-exosome pathway in the intrinsic egress route of a DNA-binding anticancer drug | journal = Pharm. Res. | volume = 23 | issue = 8 | pages = 1687–95 | year = 2007 | pmid = 16841193 | doi = 10.1007/s11095-006-9043-0 }}
+* {{cite journal | vauthors = Lambert C, Döring T, Prange R | title = Hepatitis B Virus Maturation Is Sensitive to Functional Inhibition of ESCRT-III, Vps4, and γ2-Adaptin | journal = J. Virol. | volume = 81 | issue = 17 | pages = 9050–60 | year = 2007 | pmid = 17553870 | pmc = 1951427 | doi = 10.1128/JVI.00479-07 }}
+{{Refend}}
+{{PDB Gallery|geneid=27183}}
+{{Gene-16-stub}}

VPS4A: Difference between revisions

Latest revision as of 22:36, 8 November 2017

Contents

Function

Interactions

References

Further reading

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