VIPoma causes: Difference between revisions
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==Overview== | ==Overview== | ||
There are no established causes for VIPoma.<ref name=cause>VIPoma. U.S. National Library of Medicine. https://www.nlm.nih.gov/medlineplus/ency/article/000228.htm. Accessed on October 19, 2015</ref> | There are no established causes for VIPoma.<ref name="cause">VIPoma. U.S. National Library of Medicine. https://www.nlm.nih.gov/medlineplus/ency/article/000228.htm. Accessed on October 19, 2015</ref> | ||
==Causes== | ==Causes== | ||
There are no established causes for VIPoma.<ref name=cause>VIPoma. U.S. National Library of Medicine. https://www.nlm.nih.gov/medlineplus/ency/article/000228.htm. Accessed on October 19, 2015</ref> | There are no established causes for VIPoma.<ref name="cause">VIPoma. U.S. National Library of Medicine. https://www.nlm.nih.gov/medlineplus/ency/article/000228.htm. Accessed on October 19, 2015</ref> VIP is an amino acid peptide produced by the delta-2 pancreatic islet cells.<ref name="pmid25184777">{{cite journal| author=Apodaca-Torrez FR, Triviño M, Lobo EJ, Goldenberg A, Triviño T| title=Extra-pancreatic vipoma. | journal=Arq Bras Cir Dig | year= 2014 | volume= 27 | issue= 3 | pages= 222-3 | pmid=25184777 | doi= | pmc=4676380 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25184777 }}</ref> 5 % of VIPoma that are associated with MEN-1 syndrome have genetic mutation of MEN1 gene that codes for protein menin.<ref name="pmid26564120">{{cite journal| author=Fujiya A, Kato M, Shibata T, Sobajima H| title=VIPoma with multiple endocrine neoplasia type 1 identified as an atypical gene mutation. | journal=BMJ Case Rep | year= 2015 | volume= 2015 | issue= | pages= | pmid=26564120 | doi=10.1136/bcr-2015-213016 | pmc=4654027 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26564120 }}</ref> | ||
Sporadic malignant VIPomas have altered expression of MSH2 and CXCR4 reflecting tumor aggression and potentiality of distant metastasis.<ref name="pmid23231927">{{cite journal| author=Müller S, Kupka S, Königsrainer I, Northoff H, Sotlar K, Bock T et al.| title=MSH2 and CXCR4 involvement in malignant VIPoma. | journal=World J Surg Oncol | year= 2012 | volume= 10 | issue= | pages= 264 | pmid=23231927 | doi=10.1186/1477-7819-10-264 | pmc=3544679 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23231927 }}</ref> | |||
==References== | ==References== |
Revision as of 20:18, 4 January 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Madhu Sigdel M.B.B.S.[2]Parminder Dhingra, M.D. [3]
Overview
There are no established causes for VIPoma.[1]
Causes
There are no established causes for VIPoma.[1] VIP is an amino acid peptide produced by the delta-2 pancreatic islet cells.[2] 5 % of VIPoma that are associated with MEN-1 syndrome have genetic mutation of MEN1 gene that codes for protein menin.[3]
Sporadic malignant VIPomas have altered expression of MSH2 and CXCR4 reflecting tumor aggression and potentiality of distant metastasis.[4]
References
- ↑ 1.0 1.1 VIPoma. U.S. National Library of Medicine. https://www.nlm.nih.gov/medlineplus/ency/article/000228.htm. Accessed on October 19, 2015
- ↑ Apodaca-Torrez FR, Triviño M, Lobo EJ, Goldenberg A, Triviño T (2014). "Extra-pancreatic vipoma". Arq Bras Cir Dig. 27 (3): 222–3. PMC 4676380. PMID 25184777.
- ↑ Fujiya A, Kato M, Shibata T, Sobajima H (2015). "VIPoma with multiple endocrine neoplasia type 1 identified as an atypical gene mutation". BMJ Case Rep. 2015. doi:10.1136/bcr-2015-213016. PMC 4654027. PMID 26564120.
- ↑ Müller S, Kupka S, Königsrainer I, Northoff H, Sotlar K, Bock T; et al. (2012). "MSH2 and CXCR4 involvement in malignant VIPoma". World J Surg Oncol. 10: 264. doi:10.1186/1477-7819-10-264. PMC 3544679. PMID 23231927.