VAMP3

Vesicle-associated membrane protein 3 (cellubrevin)
File:PBB Protein VAMP3 image.jpg PDB rendering based on 1kil.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1kil​, 1n7s​
Identifiers
Symbols	VAMP3 ; CEB
External IDs	Template:OMIM5 Template:MGI HomoloGene: 3511
Gene ontology Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE VAMP3 201336 at tn.png
File:PBB GE VAMP3 201337 s at tn.png
File:PBB GE VAMP3 211749 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Vesicle-associated membrane protein 3 (cellubrevin), also known as VAMP3, is a human gene.

Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Because of its high homology to other known VAMPs, its broad tissue distribution, and its subcellular localization, the protein encoded by this gene was shown to be the human equivalent of the rodent cellubrevin. In platelets the protein resides on a compartment that is not mobilized to the plasma membrane on calcium or thrombin stimulation.

Further reading

• Timmers KI, Clark AE, Omatsu-Kanbe M; et al. (1997). "Identification of SNAP receptors in rat adipose cell membrane fractions and in SNARE complexes co-immunoprecipitated with epitope-tagged N-ethylmaleimide-sensitive fusion protein". Biochem. J. 320 ( Pt 2): 429–36. PMID 8973549.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Annaert WG, Becker B, Kistner U; et al. (1998). "Export of cellubrevin from the endoplasmic reticulum is controlled by BAP31". J. Cell Biol. 139 (6): 1397–410. PMID 9396746.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Galli T, Zahraoui A, Vaidyanathan VV; et al. (1998). "A novel tetanus neurotoxin-insensitive vesicle-associated membrane protein in SNARE complexes of the apical plasma membrane of epithelial cells". Mol. Biol. Cell. 9 (6): 1437–48. PMID 9614185.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Riento K, Galli T, Jansson S; et al. (1999). "Interaction of Munc-18-2 with syntaxin 3 controls the association of apical SNAREs in epithelial cells". J. Cell. Sci. 111 ( Pt 17): 2681–8. PMID 9701566.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Prekeris R, Klumperman J, Chen YA, Scheller RH (1998). "Syntaxin 13 mediates cycling of plasma membrane proteins via tubulovesicular recycling endosomes". J. Cell Biol. 143 (4): 957–71. PMID 9817754.CS1 maint: Multiple names: authors list (link)
• Bernstein AM, Whiteheart SW (1999). "Identification of a cellubrevin/vesicle associated membrane protein 3 homologue in human platelets". Blood. 93 (2): 571–9. PMID 9885218.
• Paumet F, Le Mao J, Martin S; et al. (2000). "Soluble NSF attachment protein receptors (SNAREs) in RBL-2H3 mast cells: functional role of syntaxin 4 in exocytosis and identification of a vesicle-associated membrane protein 8-containing secretory compartment". J. Immunol. 164 (11): 5850–7. PMID 10820264.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Antonin W, Holroyd C, Fasshauer D; et al. (2001). "A SNARE complex mediating fusion of late endosomes defines conserved properties of SNARE structure and function". EMBO J. 19 (23): 6453–64. doi:10.1093/emboj/19.23.6453. PMID 11101518.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wade N, Bryant NJ, Connolly LM; et al. (2001). "Syntaxin 7 complexes with mouse Vps10p tail interactor 1b, syntaxin 6, vesicle-associated membrane protein (VAMP)8, and VAMP7 in b16 melanoma cells". J. Biol. Chem. 276 (23): 19820–7. doi:10.1074/jbc.M010838200. PMID 11278762.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Antonin W, Fasshauer D, Becker S; et al. (2002). "Crystal structure of the endosomal SNARE complex reveals common structural principles of all SNAREs". Nat. Struct. Biol. 9 (2): 107–11. doi:10.1038/nsb746. PMID 11786915.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Poschet JF, Skidmore J, Boucher JC; et al. (2002). "Hyperacidification of cellubrevin endocytic compartments and defective endosomal recycling in cystic fibrosis respiratory epithelial cells". J. Biol. Chem. 277 (16): 13959–65. doi:10.1074/jbc.M105441200. PMID 11809765.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mallard F, Tang BL, Galli T; et al. (2002). "Early/recycling endosomes-to-TGN transport involves two SNARE complexes and a Rab6 isoform". J. Cell Biol. 156 (4): 653–64. doi:10.1083/jcb.200110081. PMID 11839770.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Polgár J, Chung SH, Reed GL (2002). "Vesicle-associated membrane protein 3 (VAMP-3) and VAMP-8 are present in human platelets and are required for granule secretion". Blood. 100 (3): 1081–3. PMID 12130530.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gevaert K, Goethals M, Martens L; et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Imai A, Nashida T, Yoshie S, Shimomura H (2003). "Intracellular localisation of SNARE proteins in rat parotid acinar cells: SNARE complexes on the apical plasma membrane". Arch. Oral Biol. 48 (8): 597–604. PMID 12828989.CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Dai J, Li J, Bos E; et al. (2004). "ACAP1 promotes endocytic recycling by recognizing recycling sorting signals". Dev. Cell. 7 (5): 771–6. doi:10.1016/j.devcel.2004.10.002. PMID 15525538.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Boal F, Zhang H, Tessier C; et al. (2005). "The variable C-terminus of cysteine string proteins modulates exocytosis and protein-protein interactions". Biochemistry. 43 (51): 16212–23. doi:10.1021/bi048612+. PMID 15610015.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)