VAMP3: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Vesicle-associated membrane protein 3''' is a [[protein]] that in humans is encoded by the ''VAMP3'' [[gene]].<ref name="pmid9885218">{{cite journal | vauthors = Bernstein AM, Whiteheart SW | title = Identification of a cellubrevin/vesicle associated membrane protein 3 homologue in human platelets | journal = Blood | volume = 93 | issue = 2 | pages = 571–9 |date=Apr 1999 | pmid = 9885218 | pmc =  | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: VAMP3 vesicle-associated membrane protein 3 (cellubrevin)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9341| accessdate = }}</ref>
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{{GNF_Protein_box
| image = PBB_Protein_VAMP3_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1kil.
| PDB = {{PDB2|1kil}}, {{PDB2|1n7s}}
| Name = Vesicle-associated membrane protein 3 (cellubrevin)
| HGNCid = 12644
| Symbol = VAMP3
| AltSymbols =; CEB
| OMIM = 603657
| ECnumber =
| Homologene = 3511
| MGIid = 1321389
  | GeneAtlas_image1 = PBB_GE_VAMP3_201336_at_tn.png
  | GeneAtlas_image2 = PBB_GE_VAMP3_201337_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_VAMP3_211749_s_at_tn.png
| Function =
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} {{GNF_GO|id=GO:0019717 |text = synaptosome}} {{GNF_GO|id=GO:0045202 |text = synapse}}
| Process = {{GNF_GO|id=GO:0006461 |text = protein complex assembly}} {{GNF_GO|id=GO:0006904 |text = vesicle docking during exocytosis}} {{GNF_GO|id=GO:0006944 |text = membrane fusion}} {{GNF_GO|id=GO:0017156 |text = calcium ion-dependent exocytosis}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 9341
    | Hs_Ensembl = ENSG00000049245
    | Hs_RefseqProtein = NP_004772
    | Hs_RefseqmRNA = NM_004781
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 7753916
    | Hs_GenLoc_end = 7764079
    | Hs_Uniprot = Q15836
    | Mm_EntrezGene = 22319
    | Mm_Ensembl = ENSMUSG00000028955
    | Mm_RefseqmRNA = NM_009498
    | Mm_RefseqProtein = NP_033524
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 4
    | Mm_GenLoc_start = 149891105
    | Mm_GenLoc_end = 149901753
    | Mm_Uniprot = P63024
  }}
}}
'''Vesicle-associated membrane protein 3 (cellubrevin)''', also known as '''VAMP3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: VAMP3 vesicle-associated membrane protein 3 (cellubrevin)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9341| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =
| summary_text = Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Because of its high homology to other known VAMPs, its broad tissue distribution, and its subcellular localization, the protein encoded by this gene was shown to be the human equivalent of the rodent cellubrevin. In platelets the protein resides on a compartment that is not mobilized to the plasma membrane on calcium or thrombin stimulation.<ref name="entrez">{{cite web | title = Entrez Gene: VAMP3 vesicle-associated membrane protein 3 (cellubrevin)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9341| accessdate = }}</ref>
| summary_text = Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Because of its high homology to other known VAMPs, its broad tissue distribution, and its subcellular localization, the protein encoded by this gene was shown to be the human equivalent of the rodent cellubrevin. In platelets the protein resides on a compartment that is not mobilized to the plasma membrane on calcium or thrombin stimulation.<ref name="entrez" />
}}
}}
==Interactions==
VAMP3 has been shown to [[Protein-protein interaction|interact]] with
* [[BCAP31]],<ref name="pmid9396746">{{cite journal | vauthors = Annaert WG, Becker B, Kistner U, Reth M, Jahn R | title = Export of cellubrevin from the endoplasmic reticulum is controlled by BAP31 | journal = J. Cell Biol. | volume = 139 | issue = 6 | pages = 1397–410 |date=December 1997 | pmid = 9396746 | pmc = 2132629 | doi = 10.1083/jcb.139.6.1397| url = | issn = }}</ref>
* [[Blood vessel epicardial substance|BVES]],<ref name="pmid20057356">{{cite journal | vauthors = Hager HA, Roberts RJ, Cross EE, Proux-Gillardeaux V, Bader DM | title = Identification of a novel Bves function: regulation of vesicular transport | journal = EMBO J. | volume = 29 | issue = 3 | pages = 532–45 |date=February 2010 | pmid = 20057356 | pmc = 2830705 | doi = 10.1038/emboj.2009.379 | url = | issn = }}</ref>
* [[SNAP23]],<ref name=pmid12828989/><ref name=pmid10820264/><ref name="pmid12556468">{{cite journal | vauthors = Freedman SJ, Song HK, Xu Y, Sun ZY, Eck MJ | title = Homotetrameric structure of the SNAP-23 N-terminal coiled-coil domain | journal = J. Biol. Chem. | volume = 278 | issue = 15 | pages = 13462–7 |date=April 2003 | pmid = 12556468 | doi = 10.1074/jbc.M210483200 | url = | issn = }}</ref>
* [[STX4]],<ref name="pmid12828989">{{cite journal | vauthors = Imai A, Nashida T, Yoshie S, Shimomura H | title = Intracellular localisation of SNARE proteins in rat parotid acinar cells: SNARE complexes on the apical plasma membrane | journal = Arch. Oral Biol. | volume = 48 | issue = 8 | pages = 597–604 |date=August 2003 | pmid = 12828989 | doi = 10.1016/S0003-9969(03)00116-X| url = | issn = }}</ref><ref name="pmid10820264">{{cite journal | vauthors = Paumet F, Le Mao J, Martin S, Galli T, David B, Blank U, Roa M | title = Soluble NSF attachment protein receptors (SNAREs) in RBL-2H3 mast cells: functional role of syntaxin 4 in exocytosis and identification of a vesicle-associated membrane protein 8-containing secretory compartment | journal = J. Immunol. | volume = 164 | issue = 11 | pages = 5850–7 |date=June 2000 | pmid = 10820264 | doi = 10.4049/jimmunol.164.11.5850| url = | issn = }}</ref><ref name="pmid16189514">{{cite journal|authorlink30=Huda Zoghbi | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 |date=October 2005 | pmid = 16189514 | doi = 10.1038/nature04209 | url = | issn = }}</ref><ref name="pmid12130530">{{cite journal | vauthors = Polgár J, Chung SH, Reed GL | title = Vesicle-associated membrane protein 3 (VAMP-3) and VAMP-8 are present in human platelets and are required for granule secretion | journal = Blood | volume = 100 | issue = 3 | pages = 1081–3 |date=August 2002 | pmid = 12130530 | doi = 10.1182/blood.V100.3.1081| url = | issn = }}</ref>
* [[STX6]].<ref name="pmid11839770">{{cite journal | vauthors = Mallard F, Tang BL, Galli T, Tenza D, Saint-Pol A, Yue X, Antony C, Hong W, Goud B, Johannes L | title = Early/recycling endosomes-to-TGN transport involves two SNARE complexes and a Rab6 isoform | journal = J. Cell Biol. | volume = 156 | issue = 4 | pages = 653–64 |date=February 2002 | pmid = 11839770 | pmc = 2174079 | doi = 10.1083/jcb.200110081 | url = | issn = }}</ref>


==References==
==References==
{{reflist|2}}
{{Reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading
| citations =  
| citations =
*{{cite journal | author=Timmers KI, Clark AE, Omatsu-Kanbe M, ''et al.'' |title=Identification of SNAP receptors in rat adipose cell membrane fractions and in SNARE complexes co-immunoprecipitated with epitope-tagged N-ethylmaleimide-sensitive fusion protein. |journal=Biochem. J. |volume=320 ( Pt 2) |issue=  |pages= 429-36 |year= 1997 |pmid= 8973549 |doi=  }}
*{{cite journal   |vauthors=Timmers KI, Clark AE, Omatsu-Kanbe M, etal |title=Identification of SNAP receptors in rat adipose cell membrane fractions and in SNARE complexes co-immunoprecipitated with epitope-tagged N-ethylmaleimide-sensitive fusion protein. | series=320 |journal=Biochem. J. |volume=( Pt 2) |issue=  |pages= 429–36 |year= 1997 |pmid= 8973549 |doi= 10.1042/bj3200429| pmc=1217948 }}
*{{cite journal | author=Annaert WG, Becker B, Kistner U, ''et al.'' |title=Export of cellubrevin from the endoplasmic reticulum is controlled by BAP31. |journal=J. Cell Biol. |volume=139 |issue= 6 |pages= 1397-410 |year= 1998 |pmid= 9396746 |doi= }}
*{{cite journal   |vauthors=Annaert WG, Becker B, Kistner U, etal |title=Export of cellubrevin from the endoplasmic reticulum is controlled by BAP31. |journal=J. Cell Biol. |volume=139 |issue= 6 |pages= 1397–410 |year= 1998 |pmid= 9396746 |doi=10.1083/jcb.139.6.1397  | pmc=2132629  }}
*{{cite journal | author=Galli T, Zahraoui A, Vaidyanathan VV, ''et al.'' |title=A novel tetanus neurotoxin-insensitive vesicle-associated membrane protein in SNARE complexes of the apical plasma membrane of epithelial cells. |journal=Mol. Biol. Cell |volume=9 |issue= 6 |pages= 1437-48 |year= 1998 |pmid= 9614185 |doi=  }}
*{{cite journal   |vauthors=Galli T, Zahraoui A, Vaidyanathan VV, etal |title=A novel tetanus neurotoxin-insensitive vesicle-associated membrane protein in SNARE complexes of the apical plasma membrane of epithelial cells. |journal=Mol. Biol. Cell |volume=9 |issue= 6 |pages= 1437–48 |year= 1998 |pmid= 9614185 |doi=  10.1091/mbc.9.6.1437| pmc=25366  }}
*{{cite journal | author=Riento K, Galli T, Jansson S, ''et al.'' |title=Interaction of Munc-18-2 with syntaxin 3 controls the association of apical SNAREs in epithelial cells. |journal=J. Cell. Sci. |volume=111 ( Pt 17) |issue=  |pages= 2681-8 |year= 1999 |pmid= 9701566 |doi=  }}
*{{cite journal   |vauthors=Riento K, Galli T, Jansson S, etal |title=Interaction of Munc-18-2 with syntaxin 3 controls the association of apical SNAREs in epithelial cells. | series=111 |journal=J. Cell Sci. |volume=( Pt 17) |issue=  |pages= 2681–8 |year= 1999 |pmid= 9701566 |doi=  }}
*{{cite journal  | author=Prekeris R, Klumperman J, Chen YA, Scheller RH |title=Syntaxin 13 mediates cycling of plasma membrane proteins via tubulovesicular recycling endosomes. |journal=J. Cell Biol. |volume=143 |issue= 4 |pages= 957-71 |year= 1998 |pmid= 9817754 |doi= }}
*{{cite journal  | vauthors=Prekeris R, Klumperman J, Chen YA, Scheller RH |title=Syntaxin 13 mediates cycling of plasma membrane proteins via tubulovesicular recycling endosomes. |journal=J. Cell Biol. |volume=143 |issue= 4 |pages= 957–71 |year= 1998 |pmid= 9817754 |doi=10.1083/jcb.143.4.957  | pmc=2132958  }}
*{{cite journal | author=Bernstein AM, Whiteheart SW |title=Identification of a cellubrevin/vesicle associated membrane protein 3 homologue in human platelets. |journal=Blood |volume=93 |issue= 2 |pages= 571-9 |year= 1999 |pmid= 9885218 |doi=  }}
*{{cite journal   |vauthors=Paumet F, Le Mao J, Martin S, etal |title=Soluble NSF attachment protein receptors (SNAREs) in RBL-2H3 mast cells: functional role of syntaxin 4 in exocytosis and identification of a vesicle-associated membrane protein 8-containing secretory compartment. |journal=J. Immunol. |volume=164 |issue= 11 |pages= 5850–7 |year= 2000 |pmid= 10820264 |doi=  10.4049/jimmunol.164.11.5850}}
*{{cite journal | author=Paumet F, Le Mao J, Martin S, ''et al.'' |title=Soluble NSF attachment protein receptors (SNAREs) in RBL-2H3 mast cells: functional role of syntaxin 4 in exocytosis and identification of a vesicle-associated membrane protein 8-containing secretory compartment. |journal=J. Immunol. |volume=164 |issue= 11 |pages= 5850-7 |year= 2000 |pmid= 10820264 |doi=  }}
*{{cite journal   |vauthors=Antonin W, Holroyd C, Fasshauer D, etal |title=A SNARE complex mediating fusion of late endosomes defines conserved properties of SNARE structure and function. |journal=EMBO J. |volume=19 |issue= 23 |pages= 6453–64 |year= 2001 |pmid= 11101518 |doi= 10.1093/emboj/19.23.6453 | pmc=305878 }}
*{{cite journal | author=Antonin W, Holroyd C, Fasshauer D, ''et al.'' |title=A SNARE complex mediating fusion of late endosomes defines conserved properties of SNARE structure and function. |journal=EMBO J. |volume=19 |issue= 23 |pages= 6453-64 |year= 2001 |pmid= 11101518 |doi= 10.1093/emboj/19.23.6453 }}
*{{cite journal   |vauthors=Wade N, Bryant NJ, Connolly LM, etal |title=Syntaxin 7 complexes with mouse Vps10p tail interactor 1b, syntaxin 6, vesicle-associated membrane protein (VAMP)8, and VAMP7 in b16 melanoma cells. |journal=J. Biol. Chem. |volume=276 |issue= 23 |pages= 19820–7 |year= 2001 |pmid= 11278762 |doi= 10.1074/jbc.M010838200 }}
*{{cite journal | author=Wade N, Bryant NJ, Connolly LM, ''et al.'' |title=Syntaxin 7 complexes with mouse Vps10p tail interactor 1b, syntaxin 6, vesicle-associated membrane protein (VAMP)8, and VAMP7 in b16 melanoma cells. |journal=J. Biol. Chem. |volume=276 |issue= 23 |pages= 19820-7 |year= 2001 |pmid= 11278762 |doi= 10.1074/jbc.M010838200 }}
*{{cite journal   |vauthors=Antonin W, Fasshauer D, Becker S, etal |title=Crystal structure of the endosomal SNARE complex reveals common structural principles of all SNAREs. |journal=Nat. Struct. Biol. |volume=9 |issue= 2 |pages= 107–11 |year= 2002 |pmid= 11786915 |doi= 10.1038/nsb746 }}
*{{cite journal | author=Antonin W, Fasshauer D, Becker S, ''et al.'' |title=Crystal structure of the endosomal SNARE complex reveals common structural principles of all SNAREs. |journal=Nat. Struct. Biol. |volume=9 |issue= 2 |pages= 107-11 |year= 2002 |pmid= 11786915 |doi= 10.1038/nsb746 }}
*{{cite journal   |vauthors=Poschet JF, Skidmore J, Boucher JC, etal |title=Hyperacidification of cellubrevin endocytic compartments and defective endosomal recycling in cystic fibrosis respiratory epithelial cells. |journal=J. Biol. Chem. |volume=277 |issue= 16 |pages= 13959–65 |year= 2002 |pmid= 11809765 |doi= 10.1074/jbc.M105441200 }}
*{{cite journal | author=Poschet JF, Skidmore J, Boucher JC, ''et al.'' |title=Hyperacidification of cellubrevin endocytic compartments and defective endosomal recycling in cystic fibrosis respiratory epithelial cells. |journal=J. Biol. Chem. |volume=277 |issue= 16 |pages= 13959-65 |year= 2002 |pmid= 11809765 |doi= 10.1074/jbc.M105441200 }}
*{{cite journal   |vauthors=Mallard F, Tang BL, Galli T, etal |title=Early/recycling endosomes-to-TGN transport involves two SNARE complexes and a Rab6 isoform. |journal=J. Cell Biol. |volume=156 |issue= 4 |pages= 653–64 |year= 2002 |pmid= 11839770 |doi= 10.1083/jcb.200110081  | pmc=2174079 }}
*{{cite journal  | author=Mallard F, Tang BL, Galli T, ''et al.'' |title=Early/recycling endosomes-to-TGN transport involves two SNARE complexes and a Rab6 isoform. |journal=J. Cell Biol. |volume=156 |issue= 4 |pages= 653-64 |year= 2002 |pmid= 11839770 |doi= 10.1083/jcb.200110081 }}
*{{cite journal  | vauthors=Polgár J, Chung SH, Reed GL |title=Vesicle-associated membrane protein 3 (VAMP-3) and VAMP-8 are present in human platelets and are required for granule secretion. |journal=Blood |volume=100 |issue= 3 |pages= 1081–3 |year= 2002 |pmid= 12130530 |doi=10.1182/blood.V100.3.1081  }}
*{{cite journal | author=Polgár J, Chung SH, Reed GL |title=Vesicle-associated membrane protein 3 (VAMP-3) and VAMP-8 are present in human platelets and are required for granule secretion. |journal=Blood |volume=100 |issue= 3 |pages= 1081-3 |year= 2002 |pmid= 12130530 |doi= }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Gevaert K, Goethals M, Martens L, etal |title=Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. |journal=Nat. Biotechnol. |volume=21 |issue= 5 |pages= 566–9 |year= 2004 |pmid= 12665801 |doi= 10.1038/nbt810 }}
*{{cite journal  | author=Gevaert K, Goethals M, Martens L, ''et al.'' |title=Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. |journal=Nat. Biotechnol. |volume=21 |issue= 5 |pages= 566-9 |year= 2004 |pmid= 12665801 |doi= 10.1038/nbt810 }}
*{{cite journal  | vauthors=Imai A, Nashida T, Yoshie S, Shimomura H |title=Intracellular localisation of SNARE proteins in rat parotid acinar cells: SNARE complexes on the apical plasma membrane. |journal=Arch. Oral Biol. |volume=48 |issue= 8 |pages= 597–604 |year= 2003 |pmid= 12828989 |doi=10.1016/S0003-9969(03)00116-X  }}
*{{cite journal | author=Imai A, Nashida T, Yoshie S, Shimomura H |title=Intracellular localisation of SNARE proteins in rat parotid acinar cells: SNARE complexes on the apical plasma membrane. |journal=Arch. Oral Biol. |volume=48 |issue= 8 |pages= 597-604 |year= 2003 |pmid= 12828989 |doi=  }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Dai J, Li J, Bos E, etal |title=ACAP1 promotes endocytic recycling by recognizing recycling sorting signals. |journal=Dev. Cell |volume=7 |issue= 5 |pages= 771–6 |year= 2004 |pmid= 15525538 |doi= 10.1016/j.devcel.2004.10.002 }}
*{{cite journal | author=Dai J, Li J, Bos E, ''et al.'' |title=ACAP1 promotes endocytic recycling by recognizing recycling sorting signals. |journal=Dev. Cell |volume=7 |issue= 5 |pages= 771-6 |year= 2004 |pmid= 15525538 |doi= 10.1016/j.devcel.2004.10.002 }}
*{{cite journal   |vauthors=Boal F, Zhang H, Tessier C, etal |title=The variable C-terminus of cysteine string proteins modulates exocytosis and protein-protein interactions. |journal=Biochemistry |volume=43 |issue= 51 |pages= 16212–23 |year= 2005 |pmid= 15610015 |doi= 10.1021/bi048612+}}
*{{cite journal  | author=Boal F, Zhang H, Tessier C, ''et al.'' |title=The variable C-terminus of cysteine string proteins modulates exocytosis and protein-protein interactions. |journal=Biochemistry |volume=43 |issue= 51 |pages= 16212-23 |year= 2005 |pmid= 15610015 |doi= 10.1021/bi048612+ }}
*{{cite journal   |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=9341}}


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{{Vesicular transport proteins}}

Revision as of 22:35, 8 November 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
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View/Edit Human

Vesicle-associated membrane protein 3 is a protein that in humans is encoded by the VAMP3 gene.[1][2]

Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Because of its high homology to other known VAMPs, its broad tissue distribution, and its subcellular localization, the protein encoded by this gene was shown to be the human equivalent of the rodent cellubrevin. In platelets the protein resides on a compartment that is not mobilized to the plasma membrane on calcium or thrombin stimulation.[2]

Interactions

VAMP3 has been shown to interact with

References

  1. ↑ Bernstein AM, Whiteheart SW (Apr 1999). "Identification of a cellubrevin/vesicle associated membrane protein 3 homologue in human platelets". Blood. 93 (2): 571–9. PMID 9885218.
  2. ↑ 2.0 2.1 "Entrez Gene: VAMP3 vesicle-associated membrane protein 3 (cellubrevin)".
  3. ↑ Annaert WG, Becker B, Kistner U, Reth M, Jahn R (December 1997). "Export of cellubrevin from the endoplasmic reticulum is controlled by BAP31". J. Cell Biol. 139 (6): 1397–410. doi:10.1083/jcb.139.6.1397. PMC 2132629. PMID 9396746.
  4. ↑ Hager HA, Roberts RJ, Cross EE, Proux-Gillardeaux V, Bader DM (February 2010). "Identification of a novel Bves function: regulation of vesicular transport". EMBO J. 29 (3): 532–45. doi:10.1038/emboj.2009.379. PMC 2830705. PMID 20057356.
  5. ↑ 5.0 5.1 Imai A, Nashida T, Yoshie S, Shimomura H (August 2003). "Intracellular localisation of SNARE proteins in rat parotid acinar cells: SNARE complexes on the apical plasma membrane". Arch. Oral Biol. 48 (8): 597–604. doi:10.1016/S0003-9969(03)00116-X. PMID 12828989.
  6. ↑ 6.0 6.1 Paumet F, Le Mao J, Martin S, Galli T, David B, Blank U, Roa M (June 2000). "Soluble NSF attachment protein receptors (SNAREs) in RBL-2H3 mast cells: functional role of syntaxin 4 in exocytosis and identification of a vesicle-associated membrane protein 8-containing secretory compartment". J. Immunol. 164 (11): 5850–7. doi:10.4049/jimmunol.164.11.5850. PMID 10820264.
  7. ↑ Freedman SJ, Song HK, Xu Y, Sun ZY, Eck MJ (April 2003). "Homotetrameric structure of the SNAP-23 N-terminal coiled-coil domain". J. Biol. Chem. 278 (15): 13462–7. doi:10.1074/jbc.M210483200. PMID 12556468.
  8. ↑ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
  9. ↑ Polgár J, Chung SH, Reed GL (August 2002). "Vesicle-associated membrane protein 3 (VAMP-3) and VAMP-8 are present in human platelets and are required for granule secretion". Blood. 100 (3): 1081–3. doi:10.1182/blood.V100.3.1081. PMID 12130530.
  10. ↑ Mallard F, Tang BL, Galli T, Tenza D, Saint-Pol A, Yue X, Antony C, Hong W, Goud B, Johannes L (February 2002). "Early/recycling endosomes-to-TGN transport involves two SNARE complexes and a Rab6 isoform". J. Cell Biol. 156 (4): 653–64. doi:10.1083/jcb.200110081. PMC 2174079. PMID 11839770.

Further reading


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