Uveal melanoma medical therapy

Uveal melanoma Microchapters
Home
Patient Information
Overview
Historical Perspective
Classification
Pathophysiology
Causes
Differentiating Uveal melanoma from other Diseases
Epidemiology and Demographics
Risk Factors
Screening
Natural History, Complications and Prognosis
Diagnosis
Diagnostic Study of Choice
History and Symptoms
Physical Examination
Laboratory Findings
Electrocardiogram
X Ray
Echocardiography and Ultrasound
CT
MRI
Other Imaging Findings
Other Diagnostic Studies
Treatment
Medical Therapy
Surgery
Primary Prevention
Secondary Prevention
Cost-Effectiveness of Therapy
Future or Investigational Therapies
Case Studies
Case #1
Uveal melanoma medical therapy On the Web
Most recent articles
cited articles
Review articles
CME Programs
Powerpoint slides
Images
American Roentgen Ray Society Images of Uveal melanoma medical therapy All Images X-rays Echo & Ultrasound CT Images MRI
Ongoing Trials at Clinical Trials.gov
US National Guidelines Clearinghouse
NICE Guidance
FDA on Uveal melanoma medical therapy
CDC on Uveal melanoma medical therapy
Uveal melanoma medical therapy in the news
Blogs on Uveal melanoma medical therapy
to Hospitals Treating Uveal melanoma
Risk calculators and risk factors for Uveal melanoma medical therapy

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Fahimeh Shojaei, M.D., Simrat Sarai, M.D. [2]

Medical Therapy

Pharmacologic medical therapy is recommended among patients with metastatic disease:

• Chemotherapy
  • Dacarbazine
  • Temozolomide
  • Cisplatin
  • Treosulfan
  • Fotemustine
• Immunotherapy
  • Checkpoint blockade
    • Pembrolizumab
    • Ipilimumab + nivolumab
    • Ipilimumab + nivolumab
    • Ipilimumab + radioembolization
    • Ipilimumab + nivolumab +radioembolization
  • TILs
  • T cell redirection
  • Antibody–drug conjugate
    • Glembatumumab vedotin
• Targeted therapy
  • PKC/MEK
    • AEB071 + BYL719
    • Intermittent selumetinib
    • Selumetinib +/– paclitaxel
    • Binimetinib + AEB071
  • Multikinase inhibition
    • Sorafenib (STREAM)
    • Cabozantinib versus temozolomide/ dacarbazine
  • Epigenetic therapy
    • HDAC inhibition
      • Vorinostat
      • Pembrolizumab + entinostat (PEMDAC)
    • BET inhibition
  • Liver-directed therapy
    • IHP
    • PHP