User:C Michael Gibson

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C. Michael Gibson M.S., M.D., Associate Professor of Medicine, Harvard Medical School

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Contact: mgibson@perfuse.org; Phone 617-525-6884

Dr. Gibson received his B.S., M.S., and M.D. degrees from the University of Chicago. He was an Intern, Resident and Chief Resident at the Brigham and Women’s Hospital, Harvard Medical School. He received his training as an interventional cardiologist and served as the Director of the Coronary Care Unit at Beth Israel Hospital, Harvard Medical School. Dr. Gibson then served as the Chief of Cardiology and Director of Interventional Cardiology at the West Roxbury Veterans Affairs Medical Center, Harvard Medical School. While at the West Roxbury VA, he also served as an Associate Physician at the Brigham and Women’s Hospital. He then moved on to Allegheny General Hospital as Vice Chairman of Medicine for Clinical Research and Director of Invasive Cardiology. He subsequently relocated to the west coast and served as Associate Chief of Cardiology, Chief of Interventional Cardiology and Director of the Cardiac Catheterization Laboratory at University of California San Francisco (UCSF). Dr. Gibson has now returned to Harvard Medical School in Boston. Until 2003, Dr. Gibson served as Chief Academic Officer and Director of Core Services at Harvard Clinical Research Institute (HCRI), and until 2005 he served as Associate Chief of Cardiology and Director of Academic Affairs in the Cardiovascular Division at the Beth Israel Deaconess Medical Center. He is currently Director of the TIMI Data Coordinating Center at the Brigham and Women’s Hospital and has a staff appointment at Beth Israel Deaconess Medical Center where he is an interventional cardiologist.

Dr. Gibson’s work has largely focused on the development of the statistical and angiographic methods to investigate the pathophysiology of coronary artery disease and the efficacy of therapeutic modalities. He directs the angiographic core laboratory for a wide variety of studies including acute MI studies, unstable angina studies, interventional trials, peripheral interventional trials, angiogenesis trials (VEGF), imaging modality studies, managed care analyses for HCFA, and atherosclerosis regression trials such as the NIH-sponsored Harvard Atherosclerosis Reversibility Project (HARP). His work has been presented in over 1000 manuscripts, abstracts, trial summaries, textbooks and textbook chapters.


Within the Thrombolysis In Myocardial Infarction (TIMI) Study Group, Dr. Gibson is a Principle Investigator of multiple international acute MI trials within the TIMI Study Chairman’s Office and is Director of the TIMI Data Coordinating Center. Dr. Gibson led the creation of the master database that unifies data from over 15 years of TIMI studies in over 50,000 patients. Dr. Gibson is also Director of the TIMI Angiographic Core Laboratory and invented the TIMI frame count (CTFC) in which the number of cineframes for dye to reach standardized distal landmarks is counted (an index of epicardial blood flow). Dr. Gibson also invented the TIMI myocardial perfusion grade (a measure of microvascular perfusion. The TIMI frame count and the TIMI myocardial perfusion grade are both multivariate predictors of 2 year mortality in acute MI, and are now widely used both clinically and in the assessment of new reperfusion strategies. Dr. Gibson recently introduced the concept of the Angiographic Perfusion Score.


Dr. Gibson is on the editorial board of Circulation, and www.theheart.org. Dr. Gibson is Editor-in-Chief of www.clinicaltrialresults.org and www.timi.org which have had many millions of hits and slide downloads. As Associate Editor, he authors the summaries of cardiovascular clinical trials at the American College of Cardiology’s new website www.cardiosource.com. Over 1200 trials are summarized there.


Dr. Gibson edited a textbook entitled “Management Strategies in Interventional Cardiology” which is optimized for hand held devices. Dr. Gibson authors the chapter on Primary Angioplasty in Randomized Trials in Cardiovascular Disease published as a companion to Braunwald's Heart Disease. He co-authors the chapter “Recognition and Management of Patients with Stable Angina Pectoris in Braunwald and Goldman’s Primary Cardiology and co-authors the chapter on Quantitative Coronary Arteriography in Topol’s textbook of Interventional Cardiology. He is lead author of the section on myocardial perfusion imaging in a new imaging textbook which is a companion to Braunwald’s Heart Disease.


Dr. Gibson lectures internationally on the topics of acute MI, acute coronary syndromes, atherosclerosis, interventional cardiology and angiogenesis.


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