UTY (gene)

Ubiquitously transcribed tetratricopeptide repeat gene, Y-linked
Identifiers
Symbols	UTY ; DKFZp686L12190; UTY1
External IDs	Template:OMIM5 HomoloGene: 56022
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO
RNA expression pattern
File:PBB GE UTY 208067 x at tn.png
File:PBB GE UTY 211149 at tn.png
File:PBB GE UTY 210322 x at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Ubiquitously transcribed tetratricopeptide repeat gene, Y-linked, also known as UTY, is a human gene.

This gene encodes a protein containing tetratricopeptide repeats which are thought to be involved in protein-protein interactions. This protein is a minor histocompatibility antigen which may induce graft rejection of male stem cell grafts. Alternative splicing results in multiple transcript variants encoding different isoforms.

Further reading

• Greenfield A, Scott D, Pennisi D; et al. (1997). "An H-YDb epitope is encoded by a novel mouse Y chromosome gene". Nat. Genet. 14 (4): 474–8. doi:10.1038/ng1296-474. PMID 8944031.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lahn BT, Page DC (1997). "Functional coherence of the human Y chromosome". Science. 278 (5338): 675–80. PMID 9381176.
• Greenfield A, Carrel L, Pennisi D; et al. (1998). "The UTX gene escapes X inactivation in mice and humans". Hum. Mol. Genet. 7 (4): 737–42. PMID 9499428.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Grbavec D, Lo R, Liu Y; et al. (1999). "Groucho/transducin-like enhancer of split (TLE) family members interact with the yeast transcriptional co-repressor SSN6 and mammalian SSN6-related proteins: implications for evolutionary conservation of transcription repression mechanisms". Biochem. J. 337 ( Pt 1): 13–7. PMID 9854018.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Warren EH, Gavin MA, Simpson E; et al. (2000). "The human UTY gene encodes a novel HLA-B8-restricted H-Y antigen". J. Immunol. 164 (5): 2807–14. PMID 10679124.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Foresta C, Ferlin A, Moro E (2000). "Deletion and expression analysis of AZFa genes on the human Y chromosome revealed a major role for DBY in male infertility". Hum. Mol. Genet. 9 (8): 1161–9. PMID 10767340.CS1 maint: Multiple names: authors list (link)
• Shen P, Wang F, Underhill PA; et al. (2000). "Population genetic implications from sequence variation in four Y chromosome genes". Proc. Natl. Acad. Sci. U.S.A. 97 (13): 7354–9. PMID 10861003.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Vogt MH, Goulmy E, Kloosterboer FM; et al. (2000). "UTY gene codes for an HLA-B60-restricted human male-specific minor histocompatibility antigen involved in stem cell graft rejection: characterization of the critical polymorphic amino acid residues for T-cell recognition". Blood. 96 (9): 3126–32. PMID 11049993.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gevaert K, Goethals M, Martens L; et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Skaletsky H, Kuroda-Kawaguchi T, Minx PJ; et al. (2003). "The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes". Nature. 423 (6942): 825–37. doi:10.1038/nature01722. PMID 12815422.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Agate RJ, Choe M, Arnold AP (2004). "Sex differences in structure and expression of the sex chromosome genes CHD1Z and CHD1W in zebra finches". Mol. Biol. Evol. 21 (2): 384–96. doi:10.1093/molbev/msh027. PMID 14660691.CS1 maint: Multiple names: authors list (link)
• Gerrard DT, Filatov DA (2005). "Positive and negative selection on mammalian Y chromosomes". Mol. Biol. Evol. 22 (6): 1423–32. doi:10.1093/molbev/msi128. PMID 15758204.