USP6

Ubiquitin specific peptidase 6 (Tre-2 oncogene)
Identifiers
Symbols	USP6 ; TRE2; HRP1; TRE17; Tre-2
External IDs	Template:OMIM5
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE USP6 206405 x at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Ubiquitin specific peptidase 6 (Tre-2 oncogene), also known as USP6, is a human gene.

Further reading

• D'Andrea A, Pellman D (1999). "Deubiquitinating enzymes: a new class of biological regulators". Crit. Rev. Biochem. Mol. Biol. 33 (5): 337–52. PMID 9827704.
• Puente XS, Sánchez LM, Overall CM, López-Otín C (2003). "Human and mouse proteases: a comparative genomic approach". Nat. Rev. Genet. 4 (7): 544–58. doi:10.1038/nrg1111. PMID 12838346.CS1 maint: Multiple names: authors list (link)
• Hoogendijk JE, Hensels GW, Gabreëls-Festen AA; et al. (1992). "De-novo mutation in hereditary motor and sensory neuropathy type I.". Lancet. 339 (8801): 1081–2. PMID 1349106.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nakamura T, Hillova J, Mariage-Samson R; et al. (1992). "A novel transcriptional unit of the tre oncogene widely expressed in human cancer cells". Oncogene. 7 (4): 733–41. PMID 1565468.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Papa FR, Hochstrasser M (1993). "The yeast DOA4 gene encodes a deubiquitinating enzyme related to a product of the human tre-2 oncogene". Nature. 366 (6453): 313–9. doi:10.1038/366313a0. PMID 8247125.
• Onno M, Nakamura T, Hillova J, Hill M (1993). "Identification of novel sequences in the repertoire of hypervariable TRE17 genes from immortalized nonmalignant and malignant human keratinocytes". Gene. 131 (2): 209–15. PMID 8406013.CS1 maint: Multiple names: authors list (link)
• Onno M, Nakamura T, Mariage-Samson R; et al. (1993). "Human TRE17 oncogene is generated from a family of homologous polymorphic sequences by single-base changes". DNA Cell Biol. 12 (2): 107–18. PMID 8471161.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Paulding CA, Ruvolo M, Haber DA (2003). "The Tre2 (USP6) oncogene is a hominoid-specific gene". Proc. Natl. Acad. Sci. U.S.A. 100 (5): 2507–11. doi:10.1073/pnas.0437015100. PMID 12604796.CS1 maint: Multiple names: authors list (link)
• Masuda-Robens JM, Kutney SN, Qi H, Chou MM (2003). "The TRE17 oncogene encodes a component of a novel effector pathway for Rho GTPases Cdc42 and Rac1 and stimulates actin remodeling". Mol. Cell. Biol. 23 (6): 2151–61. PMID 12612085.CS1 maint: Multiple names: authors list (link)
• Bizimungu C, De Neve N, Burny A; et al. (2003). "Expression in a RabGAP yeast mutant of two human homologues, one of which is an oncogene". Biochem. Biophys. Res. Commun. 310 (2): 498–504. PMID 14521938.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Oliveira AM, Hsi BL, Weremowicz S; et al. (2004). "USP6 (Tre2) fusion oncogenes in aneurysmal bone cyst". Cancer Res. 64 (6): 1920–3. PMID 15026324.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Oliveira AM, Perez-Atayde AR, Inwards CY; et al. (2004). "USP6 and CDH11 oncogenes identify the neoplastic cell in primary aneurysmal bone cysts and are absent in so-called secondary aneurysmal bone cysts". Am. J. Pathol. 165 (5): 1773–80. PMID 15509545.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Martinu L, Masuda-Robens JM, Robertson SE; et al. (2004). "The TBC (Tre-2/Bub2/Cdc16) domain protein TRE17 regulates plasma membrane-endosomal trafficking through activation of Arf6". Mol. Cell. Biol. 24 (22): 9752–62. doi:10.1128/MCB.24.22.9752-9762.2004. PMID 15509780.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Oliveira AM, Perez-Atayde AR, Dal Cin P; et al. (2005). "Aneurysmal bone cyst variant translocations upregulate USP6 transcription by promoter swapping with the ZNF9, COL1A1, TRAP150, and OMD genes". Oncogene. 24 (21): 3419–26. doi:10.1038/sj.onc.1208506. PMID 15735689.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bizimungu C, Vandenbol M (2005). "At least two regions of the oncoprotein Tre2 are involved in its lack of GAP activity". Biochem. Biophys. Res. Commun. 335 (3): 883–90. doi:10.1016/j.bbrc.2005.07.159. PMID 16099424.
• Shen C, Ye Y, Robertson SE; et al. (2006). "Calcium/calmodulin regulates ubiquitination of the ubiquitin-specific protease TRE17/USP6". J. Biol. Chem. 280 (43): 35967–73. doi:10.1074/jbc.M505220200. PMID 16127172.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Dechamps C, Bach S, Portetelle D, Vandenbol M (2006). "The Tre2 oncoprotein, implicated in Ewing's sarcoma, interacts with two components of the cytoskeleton". Biotechnol. Lett. 28 (4): 223–31. doi:10.1007/s10529-005-5523-2. PMID 16555005.CS1 maint: Multiple names: authors list (link)