USP4
| Ubiquitin specific peptidase 4 (proto-oncogene) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||
| Symbols | USP4 ; MGC149848; MGC149849; UNP; Unph | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 20716 | ||||||||||
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| RNA expression pattern | |||||||||||
| File:PBB GE USP4 211800 s at tn.png | |||||||||||
| File:PBB GE USP4 202681 at tn.png | |||||||||||
| File:PBB GE USP4 202682 s at tn.png | |||||||||||
| More reference expression data | |||||||||||
| Orthologs | |||||||||||
| Template:GNF Ortholog box | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
| Ensembl | n/a | n/a | |||||||||
| UniProt | n/a | n/a | |||||||||
| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
| PubMed search | n/a | n/a | |||||||||
Ubiquitin specific peptidase 4 (proto-oncogene), also known as USP4, is a human gene.[1]
References
Further reading
- D'Andrea A, Pellman D (1999). "Deubiquitinating enzymes: a new class of biological regulators". Crit. Rev. Biochem. Mol. Biol. 33 (5): 337–52. PMID 9827704.
- Puente XS, Sánchez LM, Overall CM, López-Otín C (2003). "Human and mouse proteases: a comparative genomic approach". Nat. Rev. Genet. 4 (7): 544–58. doi:10.1038/nrg1111. PMID 12838346.
- Gray DA, Inazawa J, Gupta K; et al. (1995). "Elevated expression of Unph, a proto-oncogene at 3p21.3, in human lung tumors". Oncogene. 10 (11): 2179–83. PMID 7784062.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
- Gupta K, Chevrette M, Gray DA (1994). "The Unp proto-oncogene encodes a nuclear protein". Oncogene. 9 (6): 1729–31. PMID 8183569.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.
- Frederick A, Rolfe M, Chiu MI (1998). "The human UNP locus at 3p21.31 encodes two tissue-selective, cytoplasmic isoforms with deubiquitinating activity that have reduced expression in small cell lung carcinoma cell lines". Oncogene. 16 (2): 153–65. doi:10.1038/sj.onc.1201537. PMID 9464533.
- Di Donato F, Chan EK, Askanase AD; et al. (2001). "Interaction between 52 kDa SSA/Ro and deubiquitinating enzyme UnpEL: a clue to function". Int. J. Biochem. Cell Biol. 33 (9): 924–34. PMID 11461834.
- Blanchette P, Gilchrist CA, Baker RT, Gray DA (2001). "Association of UNP, a ubiquitin-specific protease, with the pocket proteins pRb, p107 and p130". Oncogene. 20 (39): 5533–7. doi:10.1038/sj.onc.1204823. PMID 11571651.
- DeSalle LM, Latres E, Lin D; et al. (2001). "The de-ubiquitinating enzyme Unp interacts with the retinoblastoma protein". Oncogene. 20 (39): 5538–42. doi:10.1038/sj.onc.1204824. PMID 11571652.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
- Wada K, Tanji K, Kamitani T (2006). "Oncogenic protein UnpEL/Usp4 deubiquitinates Ro52 by its isopeptidase activity". Biochem. Biophys. Res. Commun. 339 (3): 731–6. doi:10.1016/j.bbrc.2005.11.076. PMID 16316627.
- Wada K, Kamitani T (2006). "UnpEL/Usp4 is ubiquitinated by Ro52 and deubiquitinated by itself". Biochem. Biophys. Res. Commun. 342 (1): 253–8. doi:10.1016/j.bbrc.2006.01.144. PMID 16472766.
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