UPK2: Difference between revisions

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'''Uroplakin-2''' is a [[protein]] that in humans is encoded by the ''UPK2'' [[gene]].<ref name="pmid9515818">{{cite journal | vauthors = Wu RL, Osman I, Wu XR, Lu ML, Zhang ZF, Liang FX, Hamza R, Scher H, Cordon-Cardo C, Sun TT | title = Uroplakin II gene is expressed in transitional cell carcinoma but not in bilharzial bladder squamous cell carcinoma: alternative pathways of bladder epithelial differentiation and tumor formation | journal = Cancer Res | volume = 58 | issue = 6 | pages = 1291–7 |date=Apr 1998 | pmid = 9515818 | pmc =  | doi =  10.1097/00005392-199811000-00097}}</ref><ref name="pmid9846985">{{cite journal | vauthors = Lobban ED, Smith BA, Hall GD, Harnden P, Roberts P, Selby PJ, Trejdosiewicz LK, Southgate J | title = Uroplakin gene expression by normal and neoplastic human urothelium | journal = Am J Pathol | volume = 153 | issue = 6 | pages = 1957–67 |date=Dec 1998 | pmid = 9846985 | pmc = 1866332 | doi =10.1016/S0002-9440(10)65709-4 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: UPK2 uroplakin 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7379| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source =
| PDB =  
| Name = Uroplakin 2
| HGNCid = 12579
| Symbol = UPK2
| AltSymbols =; MGC138598
| OMIM =
| ECnumber =
  | Homologene = 4920
  | MGIid = 98913
| GeneAtlas_image1 = PBB_GE_UPK2_207862_at_tn.png
| Function =
| Component = {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0030176 |text = integral to endoplasmic reticulum membrane}}
| Process = {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0016044 |text = membrane organization and biogenesis}} {{GNF_GO|id=GO:0030855 |text = epithelial cell differentiation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 7379
    | Hs_Ensembl = ENSG00000110375
    | Hs_RefseqProtein = NP_006751
    | Hs_RefseqmRNA = NM_006760
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 11
    | Hs_GenLoc_start = 118332236
    | Hs_GenLoc_end = 118334478
    | Hs_Uniprot = O00526
    | Mm_EntrezGene = 22269
    | Mm_Ensembl = ENSMUSG00000041523
    | Mm_RefseqmRNA = NM_009476
    | Mm_RefseqProtein = NP_033502
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 9
    | Mm_GenLoc_start = 44203720
    | Mm_GenLoc_end = 44205762
    | Mm_Uniprot = Q3SXK0
  }}
}}
'''Uroplakin 2''', also known as '''UPK2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: UPK2 uroplakin 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7379| accessdate = }}</ref>
 
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==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Lin JH, Wu XR, Kreibich G, Sun TT |title=Precursor sequence, processing, and urothelium-specific expression of a major 15-kDa protein subunit of asymmetric unit membrane. |journal=J. Biol. Chem. |volume=269 |issue= 3 |pages= 1775-84 |year= 1994 |pmid= 7507484 |doi=  }}
*{{cite journal  | vauthors=Lin JH, Wu XR, Kreibich G, Sun TT |title=Precursor sequence, processing, and urothelium-specific expression of a major 15-kDa protein subunit of asymmetric unit membrane |journal=J. Biol. Chem. |volume=269 |issue= 3 |pages= 1775–84 |year= 1994 |pmid= 7507484 |doi=  }}
*{{cite journal | author=Wu XR, Lin JH, Walz T, ''et al.'' |title=Mammalian uroplakins. A group of highly conserved urothelial differentiation-related membrane proteins. |journal=J. Biol. Chem. |volume=269 |issue= 18 |pages= 13716-24 |year= 1994 |pmid= 8175808 |doi=  }}
*{{cite journal   |vauthors=Wu XR, Lin JH, Walz T, etal |title=Mammalian uroplakins. A group of highly conserved urothelial differentiation-related membrane proteins |journal=J. Biol. Chem. |volume=269 |issue= 18 |pages= 13716–24 |year= 1994 |pmid= 8175808 |doi=  }}
*{{cite journal | author=Wu RL, Osman I, Wu XR, ''et al.'' |title=Uroplakin II gene is expressed in transitional cell carcinoma but not in bilharzial bladder squamous cell carcinoma: alternative pathways of bladder epithelial differentiation and tumor formation. |journal=Cancer Res. |volume=58 |issue= 6 |pages= 1291-7 |year= 1998 |pmid= 9515818 |doi=  }}
*{{cite journal   |vauthors=Yuasa T, Yoshiki T, Isono T, etal |title=Expression of transitional cell-specific genes, uroplakin Ia and II, in bladder cancer: detection of circulating cancer cells in the peripheral blood of metastatic patients |journal=Int. J. Urol. |volume=6 |issue= 6 |pages= 286–92 |year= 1999 |pmid= 10404304 |doi=10.1046/j.1442-2042.1999.00064.x }}
*{{cite journal  | author=Lobban ED, Smith BA, Hall GD, ''et al.'' |title=Uroplakin gene expression by normal and neoplastic human urothelium. |journal=Am. J. Pathol. |volume=153 |issue= 6 |pages= 1957-67 |year= 1998 |pmid= 9846985 |doi=  }}
*{{cite journal   |vauthors=Li SM, Zhang ZT, Chan S, etal |title=Detection of circulating uroplakin-positive cells in patients with transitional cell carcinoma of the bladder |journal=J. Urol. |volume=162 |issue= 3 Pt 1 |pages= 931–5 |year= 1999 |pmid= 10458411 |doi=10.1097/00005392-199909010-00093 }}
*{{cite journal  | author=Yuasa T, Yoshiki T, Isono T, ''et al.'' |title=Expression of transitional cell-specific genes, uroplakin Ia and II, in bladder cancer: detection of circulating cancer cells in the peripheral blood of metastatic patients. |journal=Int. J. Urol. |volume=6 |issue= 6 |pages= 286-92 |year= 1999 |pmid= 10404304 |doi=  }}
*{{cite journal  | vauthors=Ogawa K, Johansson SL, Cohen SM |title=Immunohistochemical analysis of uroplakins, urothelial specific proteins, in ovarian Brenner tumors, normal tissues, and benign and neoplastic lesions of the female genital tract |journal=Am. J. Pathol. |volume=155 |issue= 4 |pages= 1047–50 |year= 1999 |pmid= 10514386 |doi= 10.1016/S0002-9440(10)65206-6| pmc=1867018 }}
*{{cite journal | author=Li SM, Zhang ZT, Chan S, ''et al.'' |title=Detection of circulating uroplakin-positive cells in patients with transitional cell carcinoma of the bladder. |journal=J. Urol. |volume=162 |issue= 3 Pt 1 |pages= 931-5 |year= 1999 |pmid= 10458411 |doi=  }}
*{{cite journal  | vauthors=Tu L, Sun TT, Kreibich G |title=Specific heterodimer formation is a prerequisite for uroplakins to exit from the endoplasmic reticulum |journal=Mol. Biol. Cell |volume=13 |issue= 12 |pages= 4221–30 |year= 2003 |pmid= 12475947 |doi= 10.1091/mbc.E02-04-0211 | pmc=138628 }}
*{{cite journal  | author=Ogawa K, Johansson SL, Cohen SM |title=Immunohistochemical analysis of uroplakins, urothelial specific proteins, in ovarian Brenner tumors, normal tissues, and benign and neoplastic lesions of the female genital tract. |journal=Am. J. Pathol. |volume=155 |issue= 4 |pages= 1047-50 |year= 1999 |pmid= 10514386 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal  | author=Tu L, Sun TT, Kreibich G |title=Specific heterodimer formation is a prerequisite for uroplakins to exit from the endoplasmic reticulum. |journal=Mol. Biol. Cell |volume=13 |issue= 12 |pages= 4221-30 |year= 2003 |pmid= 12475947 |doi= 10.1091/mbc.E02-04-0211 }}
*{{cite journal   |vauthors=Hirata H, Hisatomi H, Kawakita M, etal |title=Genetic detection for hematogenous micrometastasis in patients with various types of malignant tumors using Uroplakin II derived primers in polymerase chain reaction |journal=Oncol. Rep. |volume=10 |issue= 4 |pages= 963–6 |year= 2004 |pmid= 12792753 |doi=  10.3892/or.10.4.963}}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Hirata H, Hisatomi H, Kawakita M, ''et al.'' |title=Genetic detection for hematogenous micrometastasis in patients with various types of malignant tumors using Uroplakin II derived primers in polymerase chain reaction. |journal=Oncol. Rep. |volume=10 |issue= 4 |pages= 963-6 |year= 2004 |pmid= 12792753 |doi=  }}
*{{cite journal   |vauthors=Chen F, Zeng F, Tong Q, etal |title=Cloning of human uroplakin II gene from Chinese transitional cell carcinoma of bladder and construction of its eukaryotic expression vector |journal=J. Huazhong Univ. Sci. Technol. Med. Sci. |volume=25 |issue= 2 |pages= 188–90, 211 |year= 2006 |pmid= 16116969 |doi=10.1007/BF02873573 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Jenkins D, Bitner-Glindzicz M, Malcolm S, etal |title=Mutation analyses of Uroplakin II in children with renal tract malformations |journal=Nephrol. Dial. Transplant. |volume=21 |issue= 12 |pages= 3415–21 |year= 2007 |pmid= 17012268 |doi= 10.1093/ndt/gfl465 }}
*{{cite journal | author=Chen F, Zeng F, Tong Q, ''et al.'' |title=Cloning of human uroplakin II gene from Chinese transitional cell carcinoma of bladder and construction of its eukaryotic expression vector. |journal=J. Huazhong Univ. Sci. Technol. Med. Sci. |volume=25 |issue= 2 |pages= 188-90, 211 |year= 2006 |pmid= 16116969 |doi=  }}
*{{cite journal | author=Jenkins D, Bitner-Glindzicz M, Malcolm S, ''et al.'' |title=Mutation analyses of Uroplakin II in children with renal tract malformations. |journal=Nephrol. Dial. Transplant. |volume=21 |issue= 12 |pages= 3415-21 |year= 2007 |pmid= 17012268 |doi= 10.1093/ndt/gfl465 }}
}}
}}
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[[Category:Uroplakins]]

Latest revision as of 09:51, 17 September 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

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UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Uroplakin-2 is a protein that in humans is encoded by the UPK2 gene.[1][2][3]


References

  1. ↑ Wu RL, Osman I, Wu XR, Lu ML, Zhang ZF, Liang FX, Hamza R, Scher H, Cordon-Cardo C, Sun TT (Apr 1998). "Uroplakin II gene is expressed in transitional cell carcinoma but not in bilharzial bladder squamous cell carcinoma: alternative pathways of bladder epithelial differentiation and tumor formation". Cancer Res. 58 (6): 1291–7. doi:10.1097/00005392-199811000-00097. PMID 9515818.
  2. ↑ Lobban ED, Smith BA, Hall GD, Harnden P, Roberts P, Selby PJ, Trejdosiewicz LK, Southgate J (Dec 1998). "Uroplakin gene expression by normal and neoplastic human urothelium". Am J Pathol. 153 (6): 1957–67. doi:10.1016/S0002-9440(10)65709-4. PMC 1866332. PMID 9846985.
  3. ↑ "Entrez Gene: UPK2 uroplakin 2".

Further reading



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