https://www.wikidoc.org/index.php?title=UGT2B7&feed=atom&action=historyUGT2B7 - Revision history2024-03-28T12:00:11ZRevision history for this page on the wikiMediaWiki 1.40.0https://www.wikidoc.org/index.php?title=UGT2B7&diff=1526499&oldid=prevMatt Pijoan: 1 revision imported2019-01-10T12:10:53Z<p>1 revision imported</p>
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</td></tr></table>Matt Pijoanhttps://www.wikidoc.org/index.php?title=UGT2B7&diff=1526498&oldid=preven>JCW-CleanerBot: /* Further reading */clean up, replaced: journal = Aids → journal = AIDS2018-10-09T17:38:27Z<p><span dir="auto"><span class="autocomment">Further reading: </span>clean up, replaced: journal = Aids → journal = AIDS</span></p>
<a href="https://www.wikidoc.org/index.php?title=UGT2B7&diff=1526498&oldid=1414022">Show changes</a>en>JCW-CleanerBothttps://www.wikidoc.org/index.php?title=UGT2B7&diff=1414022&oldid=prev129.195.0.237: morphine-6-glucuronide is more potent , not less potent than morphine Klimas R, Mikus G. Morphine-6-glucuronide is responsible for the analgesic effect after morphine administration: a quantitative review of morphine, morphine-6-glucuronide, and morphine-2017-07-27T09:54:02Z<p>morphine-6-glucuronide is more potent , not less potent than morphine Klimas R, Mikus G. Morphine-6-glucuronide is responsible for the analgesic effect after morphine administration: a quantitative review of morphine, morphine-6-glucuronide, and morphine-</p>
<p><b>New page</b></p><div>{{Infobox_gene}}<br />
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'''UGT2B7''' (UDP-Glucuronosyltransferase-2B7) is a phase II [[metabolism]] [[isozyme|isoenzyme]] found to be active in the [[liver]], [[kidney]]s, [[epithelium|epithelial cells]] of the lower [[gastrointestinal tract]] and also has been reported in the [[brain]]. In humans, UDP-Glucuronosyltransferase-2B7 is encoded by the ''UGT2B7'' [[gene]].<ref name="pmid2159463">{{cite journal | vauthors = Ritter JK, Sheen YY, Owens IS | title = Cloning and expression of human liver UDP-glucuronosyltransferase in COS-1 cells. 3,4-catechol estrogens and estriol as primary substrates | journal = J. Biol. Chem. | volume = 265 | issue = 14 | pages = 7900–6 | date = May 1990 | pmid = 2159463 | doi = | url = http://www.jbc.org/cgi/pmidlookup?view=long&pmid=2159463 }}</ref><ref name="pmid7835904">{{cite journal | vauthors = Monaghan G, Clarke DJ, Povey S, See CG, Boxer M, Burchell B | title = Isolation of a human YAC contig encompassing a cluster of UGT2 genes and its regional localization to chromosome 4q13 | journal = Genomics | volume = 23 | issue = 2 | pages = 496–9 | date = September 1994 | pmid = 7835904 | doi = 10.1006/geno.1994.1531 | url = }}</ref><br />
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== Function ==<br />
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The UGTs serve a major role in the conjugation and subsequent elimination of potentially toxic [[xenobiotic]]s and endogenous compounds. UGT2B7 has unique specificity for 3,4-[[catechol]] [[estrogen]]s and [[estriol]], suggesting that it may play an important role in regulating the level and activity of these potent estrogen metabolites.<br />
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This enzyme is located on the [[endoplasmic reticulum]] and [[nuclear envelope|nuclear membrane]]s of cells. Its function is to [[catalysis|catalyse]] the conjugation of a wide variety of lipophilic [[aglycon]] substrates with [[glucuronic acid]], using [[uridine diphosphate glucuronic acid]].<br />
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Together with [[UGT2B4]], UGT2B7 is capable of glucosidation of [[hyodesoxycholic acid]] in the liver, but, unlike the 2B4 isoform, 2B7 is also able to glucuronidate various [[steroid hormones]] ([[androsterone]], [[epitestosterone]]) and [[fatty acids]].<ref name="pmid12527334">{{cite journal | vauthors = Mackenzie P, Little JM, Radominska-Pandya A | title = Glucosidation of hyodeoxycholic acid by UDP-glucuronosyltransferase 2B7 | journal = Biochem. Pharmacol. | volume = 65 | issue = 3 | pages = 417–21 | date = February 2003 | pmid = 12527334 | doi = 10.1016/S0006-2952(02)01522-8 | url = }}</ref><ref name="pmid17263731">{{cite journal | vauthors = Barre L, Fournel-Gigleux S, Finel M, Netter P, Magdalou J, Ouzzine M | title = Substrate specificity of the human UDP-glucuronosyltransferase UGT2B4 and UGT2B7. Identification of a critical aromatic amino acid residue at position 33 | journal = FEBS J. | volume = 274 | issue = 5 | pages = 1256–64 | date = March 2007 | pmid = 17263731 | doi = 10.1111/j.1742-4658.2007.05670.x }}</ref> It is also able to conjugate major classes of drugs such as analgesics ([[morphine]]), carboxylic nonsteroidal anti-inflammatory drugs ([[ketoprofen]]), and anticarcinogens (''all-trans'' [[retinoic acid]]).<ref name="pmid17263731"/> UGT2B7 is the major enzyme isoform for the metabolism of [[morphine]] to the main metabolites, [[morphine-3-glucuronide]] (M3G) which has no analgesic effect and [[morphine-6-glucuronide]] (M6G),<ref>{{cite journal | vauthors = Coffman BL, Rios GR, King CD, Tephly TR | title = Human UGT2B7 catalyzes morphine glucuronidation | journal = Drug Metab. Dispos. | volume = 25 | issue = 1 | pages = 1–4 | date = 1 January 1997 | pmid = 9010622 | url = http://dmd.aspetjournals.org/cgi/content/abstract/25/1/1 }}</ref> which has analgesic effects more potent than morphine.<ref name="van Dorp">{{cite journal | vauthors = van Dorp EL, Romberg R, Sarton E, Bovill JG, Dahan A | title = Morphine-6-glucuronide: morphine's successor for postoperative pain relief? | journal = Anesthesia and Analgesia | volume = 102 | issue = 6 | pages = 1789–1797 | year = 2006 | pmid = 16717327 | doi = 10.1213/01.ane.0000217197.96784.c3 | url = http://www.anesthesia-analgesia.org/cgi/content/full/102/6/1789 }}</ref> As a consequence, altered UGT2B7 activity can significantly affect both the effectiveness and side-effects of morphine, as well as some related opiate drugs.<ref>{{cite journal | vauthors = Coller JK, Christrup LL, Somogyi AA | title = Role of active metabolites in the use of opioids. | journal = European journal of clinical pharmacology | volume = 65 | issue = 2 | pages = 121–39 | year = 2009 | pmid = 18958460 | doi = 10.1007/s00228-008-0570-y }}</ref><ref>{{cite journal | vauthors = Fujita K, Ando Y, Yamamoto W, Miya T, Endo H, Sunakawa Y, Araki K, Kodama K, Nagashima F, Ichikawa W, Narabayashi M, Akiyama Y, Kawara K, Shiomi M, Ogata H, Iwasa H, Okazaki Y, Hirose T, Sasaki Y | title = Association of UGT2B7 and ABCB1 genotypes with morphine-induced adverse drug reactions in Japanese patients with cancer | journal = Cancer chemotherapy and pharmacology | volume = 65 | issue = 2 | pages = 251–8 | year = 2009 | pmid = 19466410 | doi = 10.1007/s00280-009-1029-2 }}</ref><ref>{{cite journal | vauthors = Abildskov K, Weldy P, Garland M | title = Molecular Cloning of the Baboon UDP-Glucuronosyltransferase 2B Gene Family and Their Activity in Conjugating Morphine | journal = Drug metabolism and disposition: the biological fate of chemicals | volume = 38 | issue = 4 | pages = 545–53 | year = 2010 | pmid = 20071451 | pmc = 2845934 | doi = 10.1124/dmd.109.030635 }}</ref><ref>{{cite journal | vauthors = Pergolizzi JV, Raffa RB, Gould E | title = Considerations on the use of oxymorphone in geriatric patients | journal = Expert opinion on drug safety | volume = 8 | issue = 5 | pages = 603–13 | year = 2009 | pmid = 19614559 | doi = 10.1517/14740330903153854 }}</ref><ref>{{cite journal | vauthors = Rouguieg K, Picard N, Sauvage FL, Gaulier JM, Marquet P | title = Contribution of the different UDP-glucuronosyltransferase (UGT) isoforms to buprenorphine and norbuprenorphine metabolism and relationship with the main UGT polymorphisms in a bank of human liver microsomes | journal = Drug metabolism and disposition: the biological fate of chemicals | volume = 38 | issue = 1 | pages = 40–5 | year = 2010 | pmid = 19841060 | doi = 10.1124/dmd.109.029546 }}</ref><br />
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== References ==<br />
{{Reflist}}<br />
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== Further reading ==<br />
{{refbegin | 2}}<br />
* {{cite journal | vauthors = Kwara A, Lartey M, Boamah I, Rezk NL, Oliver-Commey J, Kenu E, Kashuba AD, Court MH | title = Interindividual Variability in Pharmacokinetics of Generic Nucleoside Reverse Transcriptase Inhibitors in TB/HIV Co-infected Ghanaian Patients: UGT2B7*1C is Associated with Faster Zidovudine Clearance and Glucuronidation | journal = J Clin Pharmacol | volume = 49 | issue = 9 | pages = 1079–90 | year = 2009 | pmid = 19628728 | pmc = 2749505 | doi = 10.1177/0091270009338482 }}<br />
* {{cite journal | vauthors = Canzian F, Cox DG, Setiawan VW, Stram DO, Ziegler RG, Dossus L, Beckmann L, Blanché H, Barricarte A, Berg CD, Bingham S, Buring J, Buys SS, Calle EE, Chanock SJ, Clavel-Chapelon F, DeLancey JO, Diver WR, Dorronsoro M, Haiman CA, Hallmans G, Hankinson SE, Hunter DJ, Hüsing A, Isaacs C, Khaw KT, Kolonel LN, Kraft P, Le Marchand L, Lund E, Overvad K, Panico S, Peeters PH, Pollak M, Thun MJ, Tjønneland A, Trichopoulos D, Tumino R, Yeager M, Hoover RN, Riboli E, Thomas G, Henderson BE, Kaaks R, Feigelson HS | title = Comprehensive analysis of common genetic variation in 61 genes related to steroid hormone and insulin-like growth factor-I metabolism and breast cancer risk in the NCI breast and prostate cancer cohort consortium | journal = Hum. Mol. Genet. | volume = 19 | issue = 19 | pages = 3873–84 | year = 2010 | pmid = 20634197 | pmc = 2935856 | doi = 10.1093/hmg/ddq291 }}<br />
* {{cite journal | vauthors = Hwang MS, Lee SJ, Jeong HE, Lee S, Yoo MA, Shin JG | title = Genetic variations in UDP-glucuronosyltransferase 2B7 gene (UGT2B7) in a Korean population | journal = Drug Metab. Pharmacokinet. | volume = 25 | issue = 4 | pages = 398–402 | year = 2010 | pmid = 20814162 | doi = 10.2133/dmpk.DMPK-10-SC-021 }}<br />
* {{cite journal | vauthors = Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR | title = Personalized Smoking Cessation: Interactions between Nicotine Dose, Dependence and Quit-Success Genotype Score | journal = Mol. Med. | volume = 16 | issue = 7–8 | pages = 247–53 | year = 2010 | pmid = 20379614 | pmc = 2896464 | doi = 10.2119/molmed.2009.00159 }}<br />
* {{cite journal | vauthors = Holmes MV, Shah T, Vickery C, Smeeth L, Hingorani AD, Casas JP | title = Fulfilling the Promise of Personalized Medicine? Systematic Review and Field Synopsis of Pharmacogenetic Studies | journal = PLoS ONE | volume = 4 | issue = 12 | pages = e7960 | year = 2009 | pmid = 19956635 | pmc = 2778625 | doi = 10.1371/journal.pone.0007960 }}<br />
* {{cite journal | vauthors = Kwara A, Lartey M, Sagoe KW, Kenu E, Court MH | title = CYP2B6, CYP2A6 and UGT2B7 Genetic Polymorphisms are Predictors of Efavirenz Mid-dose Concentration in HIV-infected Patients | journal = AIDS | volume = 23 | issue = 16 | pages = 2101–6 | year = 2009 | pmid = 19779319 | pmc = 2875867 | doi = 10.1097/QAD.0b013e3283319908 }}<br />
* {{cite journal | vauthors = Setlur SR, Chen CX, Hossain RR, Ha JS, Van Doren VE, Stenzel B, Steiner E, Oldridge D, Kitabayashi N, Banerjee S, Chen JY, Schäfer G, Horninger W, Lee C, Rubin MA, Klocker H, Demichelis F | title = Genetic variation of genes involved in dihydrotestosterone metabolism and the risk of prostate cancer | journal = Cancer Epidemiol. Biomarkers Prev. | volume = 19 | issue = 1 | pages = 229–39 | year = 2010 | pmid = 20056642 | doi = 10.1158/1055-9965.EPI-09-1018 }}<br />
* {{cite journal | vauthors = Sánchez MB, Herranz JL, Leno C, Arteaga R, Oterino A, Valdizán EM, Nicolás JM, Adín J, Armijo JA | title = Genetic factors associated with drug-resistance of epilepsy: relevance of stratification by patient age and aetiology of epilepsy | journal = Seizure | volume = 19 | issue = 2 | pages = 93–101 | year = 2010 | pmid = 20064729 | doi = 10.1016/j.seizure.2009.12.004 }}<br />
* {{cite journal | vauthors = Chen M, LeDuc B, Kerr S, Howe D, Williams DA | title = Identification of human UGT2B7 as the major isoform involved in the O-glucuronidation of chloramphenicol | journal = Drug Metab. Dispos. | volume = 38 | issue = 3 | pages = 368–75 | year = 2010 | pmid = 20008037 | doi = 10.1124/dmd.109.029900 }}<br />
* {{cite journal | vauthors = Ross CJ, Katzov-Eckert H, Dubé MP, Brooks B, Rassekh SR, Barhdadi A, Feroz-Zada Y, Visscher H, Brown AM, Rieder MJ, Rogers PC, Phillips MS, Carleton BC, Hayden MR | title = Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy | journal = Nat. Genet. | volume = 41 | issue = 12 | pages = 1345–9 | year = 2009 | pmid = 19898482 | doi = 10.1038/ng.478 }}<br />
* {{cite journal | vauthors = Tang L, Ye L, Singh R, Wu B, Lv C, Zhao J, Liu Z, Hu M | title = Use of Glucuronidation Fingerprinting to Describe and Predict mono- and di-Hydroxyflavone Metabolism by Recombinant UGT Isoforms and Human Intestinal and Liver Microsomes | journal = Mol. Pharm. | volume = 7 | issue = 3 | pages = 664–79 | year = 2010 | pmid = 20297805 | pmc = 2941766 | doi = 10.1021/mp900223c }}<br />
* {{cite journal | vauthors = Woillard JB, Rerolle JP, Picard N, Rousseau A, Drouet M, Munteanu E, Essig M, Marquet P, Le Meur Y | title = Risk of diarrhoea in a long-term cohort of renal transplant patients given mycophenolate mofetil: the significant role of the UGT1A8*2 variant allele | journal = Br J Clin Pharmacol | volume = 69 | issue = 6 | pages = 675–83 | year = 2010 | pmid = 20565459 | pmc = 2883760 | doi = 10.1111/j.1365-2125.2010.03625.x }}<br />
* {{cite journal | vauthors = Yu L, Qian M, Liu Y, Yao T, Zeng S | title = Stereoselective metabolism of propranolol glucuronidation by human UDP-glucuronosyltransferases 2B7 and 1A9 | journal = Chirality | volume = 22 | issue = 4 | pages = 456–61 | year = 2010 | pmid = 19644937 | doi = 10.1002/chir.20765 }}<br />
* {{cite journal | vauthors = Yang JW, Lee PH, Hutchinson IV, Pravica V, Shah T, Min DI | title = Genetic polymorphisms of MRP2 and UGT2B7 and gastrointestinal symptoms in renal transplant recipients taking mycophenolic acid | journal = Ther Drug Monit | volume = 31 | issue = 5 | pages = 542–8 | year = 2009 | pmid = 19730281 | doi = 10.1097/FTD.0b013e3181b1dd5e }}<br />
* {{cite journal | vauthors = Ahn J, Schumacher FR, Berndt SI, Pfeiffer R, Albanes D, Andriole GL, Ardanaz E, Boeing H, Bueno-de-Mesquita B, Chanock SJ, Clavel-Chapelon F, Diver WR, Feigelson HS, Gaziano JM, Giovannucci E, Haiman CA, Henderson BE, Hoover RN, Kolonel LN, Kraft P, Ma J, Le Marchand L, Overvad K, Palli D, Stattin P, Stampfer M, Stram DO, Thomas G, Thun MJ, Travis RC, Trichopoulos D, Virtamo J, Weinstein SJ, Yeager M, Kaaks R, Hunter DJ, Hayes RB | title = Quantitative trait loci predicting circulating sex steroid hormones in men from the NCI-Breast and Prostate Cancer Cohort Consortium (BPC3) | journal = Hum. Mol. Genet. | volume = 18 | issue = 19 | pages = 3749–57 | year = 2009 | pmid = 19574343 | pmc = 2742399 | doi = 10.1093/hmg/ddp302 }}<br />
* {{cite journal | vauthors = Hu M, Lui SS, Mak VW, Chu TT, Lee VW, Poon EW, Tsui TK, Ko GT, Baum L, Tam LS, Li EK, Tomlinson B | title = Pharmacogenetic analysis of lipid responses to rosuvastatin in Chinese patients | journal = Pharmacogenet. Genomics | volume = 20 | issue = 10 | pages = 634–7 | year = 2010 | pmid = 20679960 | doi = 10.1097/FPC.0b013e32833de489 }}<br />
* {{cite journal | vauthors = Zhao W, Fakhoury M, Deschênes G, Roussey G, Brochard K, Niaudet P, Tsimaratos M, André JL, Cloarec S, Cochat P, Bensman A, Azougagh S, Jacqz-Aigrain E | title = Population Pharmacokinetics and Pharmacogenetics of Mycophenolic Acid Following Administration of Mycophenolate Mofetil in De Novo Pediatric Renal-Transplant Patients | journal = Journal of clinical pharmacology | volume = 50 | issue = 11 | pages = 1280–91 | year = 2010 | pmid = 20147615 | doi = 10.1177/0091270009357429 }}<br />
* {{cite journal | vauthors = Blanca Sánchez M, Herranz JL, Leno C, Arteaga R, Oterino A, Valdizán EM, Nicolas JM, Adín J, Shushtarian M, Armijo JA | title = UGT2B7_-161C>T polymorphism is associated with lamotrigine concentration-to-dose ratio in a multivariate study | journal = Ther Drug Monit | volume = 32 | issue = 2 | pages = 177–84 | year = 2010 | pmid = 20216122 | doi = 10.1097/FTD.0b013e3181ceecc6 }}<br />
* {{cite journal | vauthors = Yong M, Schwartz SM, Atkinson C, Makar KW, Thomas SS, Newton KM, Aiello Bowles EJ, Holt VL, Leisenring WM, Lampe JW | title = Associations between polymorphisms in glucuronidation and sulfation enzymes and mammographic breast density in premenopausal women in the United States | journal = Cancer Epidemiol. Biomarkers Prev. | volume = 19 | issue = 2 | pages = 537–46 | year = 2010 | pmid = 20142249 | pmc = 2820123 | doi = 10.1158/1055-9965.EPI-09-0898 }}<br />
* {{cite journal | vauthors = Joy MS, Boyette T, Hu Y, Wang J, La M, Hogan SL, Stewart PW, Falk RJ, Dooley MA, Smith PC | title = Effects of uridine diphosphate glucuronosyltransferase 2B7 and 1A7 pharmacogenomics and patient clinical parameters on steady-state mycophenolic acid pharmacokinetics in glomerulonephritis | journal = European journal of clinical pharmacology | volume = 66 | issue = 11 | pages = 1119–30 | year = 2010 | pmid = 20567810 | doi = 10.1007/s00228-010-0846-x }}<br />
{{refend}}<br />
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== External links ==<br />
* {{MeshName|human+UGT2B7}}<br />
* {{MeshName|UGT2B7+protein,+human}}<br />
* {{cite web | url = http://www.pharmgkb.org/do/serve?objId=PA361 | title = GT2B7 | work = PharmGKB | publisher = PharmGKB | accessdate = 2009-01-13}}<br />
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{{Glycosyltransferases}}<br />
{{Enzymes}}<br />
{{Portal bar|Molecular and Cellular Biology|border=no}}<br />
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{{DEFAULTSORT:Ugt2b7}}<br />
[[Category:Transferases]]<br />
[[Category:EC 2.4.1]]</div>129.195.0.237