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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Nucleolar transcription factor 1''' is a [[protein]] that in humans is encoded by the ''UBTF'' [[gene]].<ref name="pmid9126496">{{cite journal | vauthors = Matera AG, Wu W, Imai H, O'Keefe CL, Chan EK | title = Molecular cloning of the RNA polymerase I transcription factor hUBF/NOR-90 (UBTF) gene and localization to 17q21.3 by fluorescence in situ hybridization and radiation hybrid mapping | journal = Genomics | volume = 41 | issue = 1 | pages = 135–8  | date = May 1997 | pmid = 9126496 | pmc =  | doi = 10.1006/geno.1997.4647 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: UBTF upstream binding transcription factor, RNA polymerase I| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7343| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_UBTF_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1k99.
| PDB = {{PDB2|1k99}}, {{PDB2|1l8y}}, {{PDB2|1l8z}}, {{PDB2|1v63}}, {{PDB2|1v64}}, {{PDB2|1wgf}}
| Name = Upstream binding transcription factor, RNA polymerase I
| HGNCid = 12511
| Symbol = UBTF
| AltSymbols =; NOR-90; UBF
| OMIM = 600673
| ECnumber = 
| Homologene = 7970
| MGIid = 98512
| GeneAtlas_image1 = PBB_GE_UBTF_202692_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_UBTF_214881_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003701 |text = RNA polymerase I transcription factor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005730 |text = nucleolus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006356 |text = regulation of transcription from RNA polymerase I promoter}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 7343
    | Hs_Ensembl = ENSG00000108312
    | Hs_RefseqProtein = NP_001070151
    | Hs_RefseqmRNA = NM_001076683
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 17
    | Hs_GenLoc_start = 39637928
    | Hs_GenLoc_end = 39653762
    | Hs_Uniprot = P17480
    | Mm_EntrezGene = 21429
    | Mm_Ensembl = ENSMUSG00000020923
    | Mm_RefseqmRNA = NM_001044383
    | Mm_RefseqProtein = NP_001037848
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 102122082
    | Mm_GenLoc_end = 102135080
    | Mm_Uniprot = Q05DS1
  }}
}}
'''Upstream binding transcription factor, RNA polymerase I''', also known as '''UBTF''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: UBTF upstream binding transcription factor, RNA polymerase I| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7343| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
Upstream binding factor (UBF) is a transcription factor required for expression of the 18S, 5.8S, and 28S ribosomal RNAs, along with SL1 (a complex of TBP (MIM 600075) and three TBP-associated factors or 'TAFs'). Two UBF polypeptides, of 94 and 97 kD, exist in the human (Bell et al., 1988). UBF is a nucleolar phosphoprotein with both DNA binding and transactivation domains. Sequence-specific DNA binding to the core and upstream control elements of the human rRNA promoter is mediated through several HMG boxes (Jantzen et al., 1990).[supplied by OMIM]<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = Upstream binding factor (UBF) is a transcription factor required for expression of the 18S, 5.8S, and 28S ribosomal RNAs, along with SL1 (a complex of TBP (MIM 600075) and multiple TBP-associated factors or 'TAFs'). Two UBF polypeptides, of 94 and 97 kD, exist in the human (Bell et al., 1988). UBF is a nucleolar phosphoprotein with both DNA binding and transactivation domains. Sequence-specific DNA binding to the core and upstream control elements of the human rRNA promoter is mediated through several HMG boxes (Jantzen et al., 1990).[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: UBTF upstream binding transcription factor, RNA polymerase I| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7343| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal  | author=Chan EK, Imai H, Hamel JC, Tan EM |title=Human autoantibody to RNA polymerase I transcription factor hUBF. Molecular identity of nucleolus organizer region autoantigen NOR-90 and ribosomal RNA transcription upstream binding factor. |journal=J. Exp. Med. |volume=174 |issue= 5 |pages= 1239-44 |year= 1991 |pmid= 1940801 |doi=  }}
*{{cite journal  | author=Jantzen HM, Admon A, Bell SP, Tjian R |title=Nucleolar transcription factor hUBF contains a DNA-binding motif with homology to HMG proteins. |journal=Nature |volume=344 |issue= 6269 |pages= 830-6 |year= 1990 |pmid= 2330041 |doi= 10.1038/344830a0 }}
*{{cite journal  | author=Bell SP, Learned RM, Jantzen HM, Tjian R |title=Functional cooperativity between transcription factors UBF1 and SL1 mediates human ribosomal RNA synthesis. |journal=Science |volume=241 |issue= 4870 |pages= 1192-7 |year= 1988 |pmid= 3413483 |doi=  }}
*{{cite journal  | author=Voit R, Kuhn A, Sander EE, Grummt I |title=Activation of mammalian ribosomal gene transcription requires phosphorylation of the nucleolar transcription factor UBF. |journal=Nucleic Acids Res. |volume=23 |issue= 14 |pages= 2593-9 |year= 1995 |pmid= 7651819 |doi=  }}
*{{cite journal  | author=Hempel WM, Cavanaugh AH, Hannan RD, ''et al.'' |title=The species-specific RNA polymerase I transcription factor SL-1 binds to upstream binding factor. |journal=Mol. Cell. Biol. |volume=16 |issue= 2 |pages= 557-63 |year= 1996 |pmid= 8552083 |doi=  }}
*{{cite journal  | author=Hanada K, Song CZ, Yamamoto K, ''et al.'' |title=RNA polymerase I associated factor 53 binds to the nucleolar transcription factor UBF and functions in specific rDNA transcription. |journal=EMBO J. |volume=15 |issue= 9 |pages= 2217-26 |year= 1996 |pmid= 8641287 |doi=  }}
*{{cite journal  | author=Pluta AF, Earnshaw WC |title=Specific interaction between human kinetochore protein CENP-C and a nucleolar transcriptional regulator. |journal=J. Biol. Chem. |volume=271 |issue= 31 |pages= 18767-74 |year= 1996 |pmid= 8702533 |doi=  }}
*{{cite journal  | author=Matera AG, Wu W, Imai H, ''et al.'' |title=Molecular cloning of the RNA polymerase I transcription factor hUBF/NOR-90 (UBTF) gene and localization to 17q21.3 by fluorescence in situ hybridization and radiation hybrid mapping. |journal=Genomics |volume=41 |issue= 1 |pages= 135-8 |year= 1997 |pmid= 9126496 |doi= 10.1006/geno.1997.4647 }}
*{{cite journal  | author=Whitehead CM, Winkfein RJ, Fritzler MJ, Rattner JB |title=ASE-1: a novel protein of the fibrillar centres of the nucleolus and nucleolus organizer region of mitotic chromosomes. |journal=Chromosoma |volume=106 |issue= 8 |pages= 493-502 |year= 1998 |pmid= 9426281 |doi=  }}
*{{cite journal  | author=Voit R, Hoffmann M, Grummt I |title=Phosphorylation by G1-specific cdk-cyclin complexes activates the nucleolar transcription factor UBF. |journal=EMBO J. |volume=18 |issue= 7 |pages= 1891-9 |year= 1999 |pmid= 10202152 |doi= 10.1093/emboj/18.7.1891 }}
*{{cite journal  | author=Liu CJ, Wang H, Lengyel P |title=The interferon-inducible nucleolar p204 protein binds the ribosomal RNA-specific UBF1 transcription factor and inhibits ribosomal RNA transcription. |journal=EMBO J. |volume=18 |issue= 10 |pages= 2845-54 |year= 1999 |pmid= 10329630 |doi= 10.1093/emboj/18.10.2845 }}
*{{cite journal  | author=Hannan KM, Hannan RD, Smith SD, ''et al.'' |title=Rb and p130 regulate RNA polymerase I transcription: Rb disrupts the interaction between UBF and SL-1. |journal=Oncogene |volume=19 |issue= 43 |pages= 4988-99 |year= 2000 |pmid= 11042686 |doi= 10.1038/sj.onc.1203875 }}
*{{cite journal  | author=Kalousek I, Krízková P |title=Lymphocyte mitogenic transformation is accompanied by phosphorylation of the nucleolar transcription factor UBF. |journal=Cell. Mol. Biol. (Noisy-le-grand) |volume=46 |issue= 7 |pages= 1163-71 |year= 2001 |pmid= 11075946 |doi=  }}
*{{cite journal  | author=Pelletier G, Stefanovsky VY, Faubladier M, ''et al.'' |title=Competitive recruitment of CBP and Rb-HDAC regulates UBF acetylation and ribosomal transcription. |journal=Mol. Cell |volume=6 |issue= 5 |pages= 1059-66 |year= 2002 |pmid= 11106745 |doi=  }}
*{{cite journal  | author=Miller G, Panov KI, Friedrich JK, ''et al.'' |title=hRRN3 is essential in the SL1-mediated recruitment of RNA Polymerase I to rRNA gene promoters. |journal=EMBO J. |volume=20 |issue= 6 |pages= 1373-82 |year= 2001 |pmid= 11250903 |doi= 10.1093/emboj/20.6.1373 }}
*{{cite journal  | author=Seither P, Iben S, Thiry M, Grummt I |title=PAF67, a novel protein that is associated with the initiation-competent form of RNA polymerase I. |journal=Biol. Chem. |volume=382 |issue= 8 |pages= 1163-70 |year= 2002 |pmid= 11592397 |doi=  }}
*{{cite journal  | author=Voit R, Grummt I |title=Phosphorylation of UBF at serine 388 is required for interaction with RNA polymerase I and activation of rDNA transcription. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 24 |pages= 13631-6 |year= 2002 |pmid= 11698641 |doi= 10.1073/pnas.231071698 }}
*{{cite journal  | author=Stefanovsky VY, Pelletier G, Hannan R, ''et al.'' |title=An immediate response of ribosomal transcription to growth factor stimulation in mammals is mediated by ERK phosphorylation of UBF. |journal=Mol. Cell |volume=8 |issue= 5 |pages= 1063-73 |year= 2002 |pmid= 11741541 |doi=  }}
*{{cite journal  | author=Andersen JS, Lyon CE, Fox AH, ''et al.'' |title=Directed proteomic analysis of the human nucleolus. |journal=Curr. Biol. |volume=12 |issue= 1 |pages= 1-11 |year= 2002 |pmid= 11790298 |doi=  }}
*{{cite journal  | author=Dühr S, Torres-Montaner A, Astola A, ''et al.'' |title=Molecular analysis of the 5' region of human ribosomal transcription factor UBF. |journal=DNA Seq. |volume=12 |issue= 4 |pages= 267-72 |year= 2002 |pmid= 11916260 |doi=  }}
}}
{{refend}}


{{protein-stub}}
UBTF has been shown to [[Protein-protein interaction|interact]] with:
{{WikiDoc Sources}}
* [[Casein kinase 2, alpha 1|CSNK2A1]],<ref name = pmid7651819>{{cite journal | vauthors = Voit R, Kuhn A, Sander EE, Grummt I | title = Activation of mammalian ribosomal gene transcription requires phosphorylation of the nucleolar transcription factor UBF | journal = Nucleic Acids Res. | volume = 23 | issue = 14 | pages = 2593–9  | date = July 1995 | pmid = 7651819 | pmc = 307079 | doi =  10.1093/nar/23.14.2593}}</ref>
* [[Retinoblastoma protein|RB1]],<ref name = pmid11042686>{{cite journal | vauthors = Hannan KM, Hannan RD, Smith SD, Jefferson LS, Lun M, Rothblum LI | title = Rb and p130 regulate RNA polymerase I transcription: Rb disrupts the interaction between UBF and SL-1 | journal = Oncogene | volume = 19 | issue = 43 | pages = 4988–99  | date = October 2000 | pmid = 11042686 | doi = 10.1038/sj.onc.1203875 }}</ref>
* [[TAF1C]],<ref name = pmid11698641>{{cite journal | vauthors = Voit R, Grummt I | title = Phosphorylation of UBF at serine 388 is required for interaction with RNA polymerase I and activation of rDNA transcription | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 98 | issue = 24 | pages = 13631–6  | date = November 2001 | pmid = 11698641 | pmc = 61092 | doi = 10.1073/pnas.231071698 }}</ref><ref name = pmid10913176>{{cite journal | vauthors = Zhai W, Comai L | title = Repression of RNA polymerase I transcription by the tumor suppressor p53 | journal = Mol. Cell. Biol. | volume = 20 | issue = 16 | pages = 5930–8  | date = August 2000 | pmid = 10913176 | pmc = 86070 | doi =  10.1128/mcb.20.16.5930-5938.2000}}</ref>  and
* [[TAF1]].<ref name = pmid12498690>{{cite journal | vauthors = Lin CY, Tuan J, Scalia P, Bui T, Comai L | title = The cell cycle regulatory factor TAF1 stimulates ribosomal DNA transcription by binding to the activator UBF | journal = Curr. Biol. | volume = 12 | issue = 24 | pages = 2142–6  | date = Dec 2002 | pmid = 12498690 | doi =  10.1016/s0960-9822(02)01389-1}}</ref>
 
== References ==
{{Reflist}}
 
== Further reading ==
{{Refbegin | 2}}
* {{cite journal | vauthors = Chan EK, Imai H, Hamel JC, Tan EM | title = Human autoantibody to RNA polymerase I transcription factor hUBF. Molecular identity of nucleolus organizer region autoantigen NOR-90 and ribosomal RNA transcription upstream binding factor | journal = J. Exp. Med. | volume = 174 | issue = 5 | pages = 1239–44 | year = 1991 | pmid = 1940801 | pmc = 2119007 | doi = 10.1084/jem.174.5.1239 }}
* {{cite journal | vauthors = Jantzen HM, Admon A, Bell SP, Tjian R | title = Nucleolar transcription factor hUBF contains a DNA-binding motif with homology to HMG proteins | journal = Nature | volume = 344 | issue = 6269 | pages = 830–6 | year = 1990 | pmid = 2330041 | doi = 10.1038/344830a0 }}
* {{cite journal | vauthors = Bell SP, Learned RM, Jantzen HM, Tjian R | title = Functional cooperativity between transcription factors UBF1 and SL1 mediates human ribosomal RNA synthesis | journal = Science | volume = 241 | issue = 4870 | pages = 1192–7 | year = 1988 | pmid = 3413483 | doi = 10.1126/science.3413483 }}
* {{cite journal | vauthors = Voit R, Kuhn A, Sander EE, Grummt I | title = Activation of mammalian ribosomal gene transcription requires phosphorylation of the nucleolar transcription factor UBF | journal = Nucleic Acids Res. | volume = 23 | issue = 14 | pages = 2593–9 | year = 1995 | pmid = 7651819 | pmc = 307079 | doi = 10.1093/nar/23.14.2593 }}
* {{cite journal | vauthors = Hempel WM, Cavanaugh AH, Hannan RD, Taylor L, Rothblum LI | title = The species-specific RNA polymerase I transcription factor SL-1 binds to upstream binding factor | journal = Mol. Cell. Biol. | volume = 16 | issue = 2 | pages = 557–63 | year = 1996 | pmid = 8552083 | pmc = 231034 | doi =  10.1128/MCB.16.2.557}}
* {{cite journal | vauthors = Hanada K, Song CZ, Yamamoto K, Yano K, Maeda Y, Yamaguchi K, Muramatsu M | title = RNA polymerase I associated factor 53 binds to the nucleolar transcription factor UBF and functions in specific rDNA transcription | journal = EMBO J. | volume = 15 | issue = 9 | pages = 2217–26 | year = 1996 | pmid = 8641287 | pmc = 450146 | doi =  }}
* {{cite journal | vauthors = Pluta AF, Earnshaw WC | title = Specific interaction between human kinetochore protein CENP-C and a nucleolar transcriptional regulator | journal = J. Biol. Chem. | volume = 271 | issue = 31 | pages = 18767–74 | year = 1996 | pmid = 8702533 | doi = 10.1074/jbc.271.31.18767 }}
* {{cite journal | vauthors = Whitehead CM, Winkfein RJ, Fritzler MJ, Rattner JB | title = ASE-1: a novel protein of the fibrillar centres of the nucleolus and nucleolus organizer region of mitotic chromosomes | journal = Chromosoma | volume = 106 | issue = 8 | pages = 493–502 | year = 1997 | pmid = 9426281 | doi = 10.1007/s004120050271 }}
* {{cite journal | vauthors = Voit R, Hoffmann M, Grummt I | title = Phosphorylation by G1-specific cdk-cyclin complexes activates the nucleolar transcription factor UBF | journal = EMBO J. | volume = 18 | issue = 7 | pages = 1891–9 | year = 1999 | pmid = 10202152 | pmc = 1171274 | doi = 10.1093/emboj/18.7.1891 }}
* {{cite journal | vauthors = Liu CJ, Wang H, Lengyel P | title = The interferon-inducible nucleolar p204 protein binds the ribosomal RNA-specific UBF1 transcription factor and inhibits ribosomal RNA transcription | journal = EMBO J. | volume = 18 | issue = 10 | pages = 2845–54 | year = 1999 | pmid = 10329630 | pmc = 1171365 | doi = 10.1093/emboj/18.10.2845 }}
* {{cite journal | vauthors = Hannan KM, Hannan RD, Smith SD, Jefferson LS, Lun M, Rothblum LI | title = Rb and p130 regulate RNA polymerase I transcription: Rb disrupts the interaction between UBF and SL-1 | journal = Oncogene | volume = 19 | issue = 43 | pages = 4988–99 | year = 2000 | pmid = 11042686 | doi = 10.1038/sj.onc.1203875 }}
* {{cite journal | vauthors = Kalousek I, Krízková P | title = Lymphocyte mitogenic transformation is accompanied by phosphorylation of the nucleolar transcription factor UBF | journal = Cell. Mol. Biol. (Noisy-le-grand) | volume = 46 | issue = 7 | pages = 1163–71 | year = 2000 | pmid = 11075946 | doi =  }}
* {{cite journal | vauthors = Pelletier G, Stefanovsky VY, Faubladier M, Hirschler-Laszkiewicz I, Savard J, Rothblum LI, Côté J, Moss T | title = Competitive recruitment of CBP and Rb-HDAC regulates UBF acetylation and ribosomal transcription | journal = Mol. Cell | volume = 6 | issue = 5 | pages = 1059–66 | year = 2000 | pmid = 11106745 | doi = 10.1016/S1097-2765(00)00104-0 }}
* {{cite journal | vauthors = Miller G, Panov KI, Friedrich JK, Trinkle-Mulcahy L, Lamond AI, Zomerdijk JC | title = hRRN3 is essential in the SL1-mediated recruitment of RNA Polymerase I to rRNA gene promoters | journal = EMBO J. | volume = 20 | issue = 6 | pages = 1373–82 | year = 2001 | pmid = 11250903 | pmc = 145519 | doi = 10.1093/emboj/20.6.1373 }}
* {{cite journal | vauthors = Seither P, Iben S, Thiry M, Grummt I | title = PAF67, a novel protein that is associated with the initiation-competent form of RNA polymerase I | journal = Biol. Chem. | volume = 382 | issue = 8 | pages = 1163–70 | year = 2001 | pmid = 11592397 | doi = 10.1515/BC.2001.146 }}
* {{cite journal | vauthors = Voit R, Grummt I | title = Phosphorylation of UBF at serine 388 is required for interaction with RNA polymerase I and activation of rDNA transcription | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 98 | issue = 24 | pages = 13631–6 | year = 2001 | pmid = 11698641 | pmc = 61092 | doi = 10.1073/pnas.231071698 }}
* {{cite journal | vauthors = Stefanovsky VY, Pelletier G, Hannan R, Gagnon-Kugler T, Rothblum LI, Moss T | title = An immediate response of ribosomal transcription to growth factor stimulation in mammals is mediated by ERK phosphorylation of UBF | journal = Mol. Cell | volume = 8 | issue = 5 | pages = 1063–73 | year = 2001 | pmid = 11741541 | doi = 10.1016/S1097-2765(01)00384-7 }}
* {{cite journal | vauthors = Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, Mann M, Lamond AI | title = Directed proteomic analysis of the human nucleolus | journal = Curr. Biol. | volume = 12 | issue = 1 | pages = 1–11 | year = 2002 | pmid = 11790298 | doi = 10.1016/S0960-9822(01)00650-9 }}
* {{cite journal | vauthors = Dühr S, Torres-Montaner A, Astola A, García-Cozar FJ, Pendón C, Bolívar J, Valdivia MM | title = Molecular analysis of the 5' region of human ribosomal transcription factor UBF | journal = DNA Seq. | volume = 12 | issue = 4 | pages = 267–72 | year = 2001 | pmid = 11916260 | doi = 10.3109/10425170109025001 }}
{{Refend}}
 
{{PDB Gallery|geneid=7343}}
 
 
{{Gene-17-stub}}

Latest revision as of 09:34, 17 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

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RefSeq (protein)

n/a

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Nucleolar transcription factor 1 is a protein that in humans is encoded by the UBTF gene.[1][2]

Function

Upstream binding factor (UBF) is a transcription factor required for expression of the 18S, 5.8S, and 28S ribosomal RNAs, along with SL1 (a complex of TBP (MIM 600075) and three TBP-associated factors or 'TAFs'). Two UBF polypeptides, of 94 and 97 kD, exist in the human (Bell et al., 1988). UBF is a nucleolar phosphoprotein with both DNA binding and transactivation domains. Sequence-specific DNA binding to the core and upstream control elements of the human rRNA promoter is mediated through several HMG boxes (Jantzen et al., 1990).[supplied by OMIM][2]

Interactions

UBTF has been shown to interact with:

References

  1. ↑ Matera AG, Wu W, Imai H, O'Keefe CL, Chan EK (May 1997). "Molecular cloning of the RNA polymerase I transcription factor hUBF/NOR-90 (UBTF) gene and localization to 17q21.3 by fluorescence in situ hybridization and radiation hybrid mapping". Genomics. 41 (1): 135–8. doi:10.1006/geno.1997.4647. PMID 9126496.
  2. ↑ 2.0 2.1 "Entrez Gene: UBTF upstream binding transcription factor, RNA polymerase I".
  3. ↑ Voit R, Kuhn A, Sander EE, Grummt I (July 1995). "Activation of mammalian ribosomal gene transcription requires phosphorylation of the nucleolar transcription factor UBF". Nucleic Acids Res. 23 (14): 2593–9. doi:10.1093/nar/23.14.2593. PMC 307079. PMID 7651819.
  4. ↑ Hannan KM, Hannan RD, Smith SD, Jefferson LS, Lun M, Rothblum LI (October 2000). "Rb and p130 regulate RNA polymerase I transcription: Rb disrupts the interaction between UBF and SL-1". Oncogene. 19 (43): 4988–99. doi:10.1038/sj.onc.1203875. PMID 11042686.
  5. ↑ Voit R, Grummt I (November 2001). "Phosphorylation of UBF at serine 388 is required for interaction with RNA polymerase I and activation of rDNA transcription". Proc. Natl. Acad. Sci. U.S.A. 98 (24): 13631–6. doi:10.1073/pnas.231071698. PMC 61092. PMID 11698641.
  6. ↑ Zhai W, Comai L (August 2000). "Repression of RNA polymerase I transcription by the tumor suppressor p53". Mol. Cell. Biol. 20 (16): 5930–8. doi:10.1128/mcb.20.16.5930-5938.2000. PMC 86070. PMID 10913176.
  7. ↑ Lin CY, Tuan J, Scalia P, Bui T, Comai L (Dec 2002). "The cell cycle regulatory factor TAF1 stimulates ribosomal DNA transcription by binding to the activator UBF". Curr. Biol. 12 (24): 2142–6. doi:10.1016/s0960-9822(02)01389-1. PMID 12498690.

Further reading


Retrieved from "https://www.wikidoc.org/index.php?title=UBTF&oldid=1417937"