UBE2A

Ubiquitin-conjugating enzyme E2A (RAD6 homolog)
File:PBB Protein UBE2A image.jpg PDB rendering based on 1jas.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1jas​, 1q34​, 1z3d​
Identifiers
Symbols	UBE2A ; HHR6A; RAD6A; UBC2
External IDs	Template:OMIM5 Template:MGI HomoloGene: 68308
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE UBE2A 201899 s at tn.png
File:PBB GE UBE2A 201898 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Ubiquitin-conjugating enzyme E2A (RAD6 homolog), also known as UBE2A, is a human gene.

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair. Multiple alternatively spliced transcript variants have been found for this gene and they encode distinct isoforms.

Further reading

• Koken MH, Smit EM, Jaspers-Dekker I; et al. (1992). "Localization of two human homologs, HHR6A and HHR6B, of the yeast DNA repair gene RAD6 to chromosomes Xq24-q25 and 5q23-q31". Genomics. 12 (3): 447–53. PMID 1559696.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Koken MH, Reynolds P, Jaspers-Dekker I; et al. (1991). "Structural and functional conservation of two human homologs of the yeast DNA repair gene RAD6". Proc. Natl. Acad. Sci. U.S.A. 88 (20): 8865–9. PMID 1717990.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kato S, Sekine S, Oh SW; et al. (1995). "Construction of a human full-length cDNA bank". Gene. 150 (2): 243–50. PMID 7821789.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tateishi S, Sakuraba Y, Masuyama S; et al. (2000). "Dysfunction of human Rad18 results in defective postreplication repair and hypersensitivity to multiple mutagens". Proc. Natl. Acad. Sci. U.S.A. 97 (14): 7927–32. PMID 10884424.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Xin H, Lin W, Sumanasekera W; et al. (2000). "The human RAD18 gene product interacts with HHR6A and HHR6B". Nucleic Acids Res. 28 (14): 2847–54. PMID 10908344.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Miura T, Klaus W, Ross A; et al. (2003). "The NMR structure of the class I human ubiquitin-conjugating enzyme 2b". J. Biomol. NMR. 22 (1): 89–92. PMID 11885984.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Shekhar MP, Lyakhovich A, Visscher DW; et al. (2002). "Rad6 overexpression induces multinucleation, centrosome amplification, abnormal mitosis, aneuploidy, and transformation". Cancer Res. 62 (7): 2115–24. PMID 11929833.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sarcevic B, Mawson A, Baker RT, Sutherland RL (2002). "Regulation of the ubiquitin-conjugating enzyme hHR6A by CDK-mediated phosphorylation". EMBO J. 21 (8): 2009–18. doi:10.1093/emboj/21.8.2009. PMID 11953320.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Suzumori N, Burns KH, Yan W, Matzuk MM (2003). "RFPL4 interacts with oocyte proteins of the ubiquitin-proteasome degradation pathway". Proc. Natl. Acad. Sci. U.S.A. 100 (2): 550–5. doi:10.1073/pnas.0234474100. PMID 12525704.CS1 maint: Multiple names: authors list (link)
• Lyakhovich A, Shekhar MP (2003). "Supramolecular complex formation between Rad6 and proteins of the p53 pathway during DNA damage-induced response". Mol. Cell. Biol. 23 (7): 2463–75. PMID 12640129.
• Kunapuli P, Somerville R, Still IH, Cowell JK (2003). "ZNF198 protein, involved in rearrangement in myeloproliferative disease, forms complexes with the DNA repair-associated HHR6A/6B and RAD18 proteins". Oncogene. 22 (22): 3417–23. doi:10.1038/sj.onc.1206408. PMID 12776193.CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nascimento RM, Otto PA, de Brouwer AP, Vianna-Morgante AM (2006). "UBE2A, which encodes a ubiquitin-conjugating enzyme, is mutated in a novel X-linked mental retardation syndrome". Am. J. Hum. Genet. 79 (3): 549–55. doi:10.1086/507047. PMID 16909393.CS1 maint: Multiple names: authors list (link)