UBE1L: Difference between revisions

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{{Infobox_gene}}
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'''Ubiquitin-like modifier-activating enzyme 7''' is a [[protein]] that in humans is encoded by the ''UBA7'' [[gene]].<ref name="pmid8327486">{{cite journal | vauthors = Kok K, Hofstra R, Pilz A, van den Berg A, Terpstra P, Buys CH, Carritt B | title = A gene in the chromosomal region 3p21 with greatly reduced expression in lung cancer is similar to the gene for ubiquitin-activating enzyme | journal = Proc Natl Acad Sci U S A | volume = 90 | issue = 13 | pages = 6071–5 |date=Aug 1993 | pmid = 8327486 | pmc = 46869 | doi =10.1073/pnas.90.13.6071 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: UBE1L ubiquitin-activating enzyme E1-like| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7318| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Ubiquitin-activating enzyme E1-like
| HGNCid = 12471
| Symbol = UBE1L
| AltSymbols =; D8; MGC12713; UBE2
| OMIM = 191325
| ECnumber =
| Homologene = 2502
| MGIid = 1349462
| GeneAtlas_image1 = PBB_GE_UBE1L_1294_at_tn.png
| GeneAtlas_image2 = PBB_GE_UBE1L_203281_s_at_tn.png
  | Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004839 |text = ubiquitin activating enzyme activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0008047 |text = enzyme activator activity}} {{GNF_GO|id=GO:0016874 |text = ligase activity}} {{GNF_GO|id=GO:0019782 |text = ISG15 activating enzyme activity}}
| Component =
| Process = {{GNF_GO|id=GO:0006512 |text = ubiquitin cycle}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 7318
    | Hs_Ensembl = ENSG00000182179
    | Hs_RefseqProtein = NP_003326
    | Hs_RefseqmRNA = NM_003335
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 3
    | Hs_GenLoc_start = 49817643
    | Hs_GenLoc_end = 49826395
    | Hs_Uniprot = P41226
    | Mm_EntrezGene = 74153
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = NM_023738
    | Mm_RefseqProtein = NP_076227
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''Ubiquitin-activating enzyme E1-like''', also known as '''UBE1L''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: UBE1L ubiquitin-activating enzyme E1-like| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7318| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme is a retinoid target that triggers promyelocytic leukemia (PML)/retinoic acid receptor alpha (RARalpha) degradation and apoptosis in acute promyelocytic leukemia.<ref name="entrez">{{cite web | title = Entrez Gene: UBE1L ubiquitin-activating enzyme E1-like| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7318| accessdate = }}</ref>
| summary_text = The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme is a retinoid target that triggers promyelocytic leukemia (PML)/retinoic acid receptor alpha (RARalpha) degradation and apoptosis in acute promyelocytic leukemia.<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Carritt B, Kok K, van den Berg A, ''et al.'' |title=A gene from human chromosome region 3p21 with reduced expression in small cell lung cancer. |journal=Cancer Res. |volume=52 |issue= 6 |pages= 1536-41 |year= 1992 |pmid= 1311632 |doi=  }}
*{{cite journal   |vauthors=Carritt B, Kok K, van den Berg A, etal |title=A gene from human chromosome region 3p21 with reduced expression in small cell lung cancer. |journal=Cancer Res. |volume=52 |issue= 6 |pages= 1536–41 |year= 1992 |pmid= 1311632 |doi=  }}
*{{cite journal | author=Kok K, Van den Berg A, Veldhuis PM, ''et al.'' |title=The genomic structure of the human UBE1L gene. |journal=Gene Expr. |volume=4 |issue= 3 |pages= 163-75 |year= 1995 |pmid= 7734949 |doi=  }}
*{{cite journal   |vauthors=Kok K, Van den Berg A, Veldhuis PM, etal |title=The genomic structure of the human UBE1L gene. |journal=Gene Expr. |volume=4 |issue= 3 |pages= 163–75 |year= 1995 |pmid= 7734949 |doi=  }}
*{{cite journal | author=Kok K, Hofstra R, Pilz A, ''et al.'' |title=A gene in the chromosomal region 3p21 with greatly reduced expression in lung cancer is similar to the gene for ubiquitin-activating enzyme. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 13 |pages= 6071-5 |year= 1993 |pmid= 8327486 |doi=  }}
*{{cite journal   |vauthors=McLaughlin PM, Helfrich W, Kok K, etal |title=The ubiquitin-activating enzyme E1-like protein in lung cancer cell lines. |journal=Int. J. Cancer |volume=85 |issue= 6 |pages= 871–6 |year= 2000 |pmid= 10709110 |doi=10.1002/(SICI)1097-0215(20000315)85:6<871::AID-IJC22>3.0.CO;2-O }}
*{{cite journal  | author=McLaughlin PM, Helfrich W, Kok K, ''et al.'' |title=The ubiquitin-activating enzyme E1-like protein in lung cancer cell lines. |journal=Int. J. Cancer |volume=85 |issue= 6 |pages= 871-6 |year= 2000 |pmid= 10709110 |doi=  }}
*{{cite journal  | vauthors=Yuan W, Krug RM |title=Influenza B virus NS1 protein inhibits conjugation of the interferon (IFN)-induced ubiquitin-like ISG15 protein. |journal=EMBO J. |volume=20 |issue= 3 |pages= 362–71 |year= 2001 |pmid= 11157743 |doi= 10.1093/emboj/20.3.362 | pmc=133459 }}
*{{cite journal  | author=Yuan W, Krug RM |title=Influenza B virus NS1 protein inhibits conjugation of the interferon (IFN)-induced ubiquitin-like ISG15 protein. |journal=EMBO J. |volume=20 |issue= 3 |pages= 362-71 |year= 2001 |pmid= 11157743 |doi= 10.1093/emboj/20.3.362 }}
*{{cite journal   |vauthors=Kitareewan S, Pitha-Rowe I, Sekula D, etal |title=UBE1L is a retinoid target that triggers PML/RARalpha degradation and apoptosis in acute promyelocytic leukemia. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 6 |pages= 3806–11 |year= 2002 |pmid= 11891284 |doi= 10.1073/pnas.052011299 | pmc=122605 }}
*{{cite journal | author=Kitareewan S, Pitha-Rowe I, Sekula D, ''et al.'' |title=UBE1L is a retinoid target that triggers PML/RARalpha degradation and apoptosis in acute promyelocytic leukemia. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 6 |pages= 3806-11 |year= 2002 |pmid= 11891284 |doi= 10.1073/pnas.052011299 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Gevaert K, Goethals M, Martens L, etal |title=Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. |journal=Nat. Biotechnol. |volume=21 |issue= 5 |pages= 566–9 |year= 2004 |pmid= 12665801 |doi= 10.1038/nbt810 }}
*{{cite journal | author=Gevaert K, Goethals M, Martens L, ''et al.'' |title=Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. |journal=Nat. Biotechnol. |volume=21 |issue= 5 |pages= 566-9 |year= 2004 |pmid= 12665801 |doi= 10.1038/nbt810 }}
*{{cite journal  | vauthors=Pitha-Rowe I, Hassel BA, Dmitrovsky E |title=Involvement of UBE1L in ISG15 conjugation during retinoid-induced differentiation of acute promyelocytic leukemia. |journal=J. Biol. Chem. |volume=279 |issue= 18 |pages= 18178–87 |year= 2004 |pmid= 14976209 |doi= 10.1074/jbc.M309259200 }}
*{{cite journal  | author=Pitha-Rowe I, Hassel BA, Dmitrovsky E |title=Involvement of UBE1L in ISG15 conjugation during retinoid-induced differentiation of acute promyelocytic leukemia. |journal=J. Biol. Chem. |volume=279 |issue= 18 |pages= 18178-87 |year= 2004 |pmid= 14976209 |doi= 10.1074/jbc.M309259200 }}
*{{cite journal   |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal   |vauthors=Lenschow DJ, Giannakopoulos NV, Gunn LJ, etal |title=Identification of interferon-stimulated gene 15 as an antiviral molecule during Sindbis virus infection in vivo. |journal=J. Virol. |volume=79 |issue= 22 |pages= 13974–83 |year= 2006 |pmid= 16254333 |doi= 10.1128/JVI.79.22.13974-13983.2005 | pmc=1280211 }}
*{{cite journal | author=Lenschow DJ, Giannakopoulos NV, Gunn LJ, ''et al.'' |title=Identification of interferon-stimulated gene 15 as an antiviral molecule during Sindbis virus infection in vivo. |journal=J. Virol. |volume=79 |issue= 22 |pages= 13974-83 |year= 2006 |pmid= 16254333 |doi= 10.1128/JVI.79.22.13974-13983.2005 }}
*{{cite journal   |vauthors=Takeuchi T, Iwahara S, Saeki Y, etal |title=Link between the Ubiquitin Conjugation System and the ISG15 Conjugation System: ISG15 Conjugation to the UbcH6 Ubiquitin E2 Enzyme. |journal=J. Biochem. |volume=138 |issue= 6 |pages= 711–9 |year=  2005|pmid= 16428300 |doi= 10.1093/jb/mvi172 }}
*{{cite journal | author=Takeuchi T, Iwahara S, Saeki Y, ''et al.'' |title=Link between the Ubiquitin Conjugation System and the ISG15 Conjugation System: ISG15 Conjugation to the UbcH6 Ubiquitin E2 Enzyme. |journal=J. Biochem. |volume=138 |issue= 6 |pages= 711-9 |year=  |pmid= 16428300 |doi= 10.1093/jb/mvi172 }}
}}
}}
{{refend}}
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Revision as of 09:30, 17 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Ubiquitin-like modifier-activating enzyme 7 is a protein that in humans is encoded by the UBA7 gene.[1][2]

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme is a retinoid target that triggers promyelocytic leukemia (PML)/retinoic acid receptor alpha (RARalpha) degradation and apoptosis in acute promyelocytic leukemia.[2]

References

  1. ↑ Kok K, Hofstra R, Pilz A, van den Berg A, Terpstra P, Buys CH, Carritt B (Aug 1993). "A gene in the chromosomal region 3p21 with greatly reduced expression in lung cancer is similar to the gene for ubiquitin-activating enzyme". Proc Natl Acad Sci U S A. 90 (13): 6071–5. doi:10.1073/pnas.90.13.6071. PMC 46869. PMID 8327486.
  2. ↑ 2.0 2.1 "Entrez Gene: UBE1L ubiquitin-activating enzyme E1-like".

Further reading



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