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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Ahmed Elsaiey, MBBCH [2]

Overview

Viral meningitis pathophysiology differs from virus to another and depends on many factors like age, immune status and gene expression.

Pathogenesis

  • The causative viral agents can reach the nervous system via the blood or the nerves themselves. There is a difference in both pathways pathogenesis. Viral spreading through the blood (viremia) is more common in viral meningitis pathogenesis. The viruses enter to the pulmonary and intestinal mucosa at which they spread into the blood to reach the lymph nodes where viral replication takes place and this is called primary viremia. At this point, the host cells try to prevent further replication from happening and if they fail to stop the replication, secondary viremia will take place and the viruses can spread to the nervous system. [1]

Transmission

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References

  1. Rotbart HA (2000). "Viral meningitis". Semin Neurol. 20 (3): 277–92. doi:10.1055/s-2000-9427. PMID 11051293.