Tumor lysis syndrome overview: Difference between revisions
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== Overview == | ==Overview== | ||
In [[medicine]] ([[oncology]] and [[hematology]]), '''tumor lysis syndrome''' ('''TLS''') is a group of [[metabolism|metabolic]] complications that can occur after treatment of [[cancer]], usually [[lymphoma]]s and [[leukemia]]s, and sometimes even without treatment. These complications are caused by the break-down products of dying cancer cells and include [[hyperkalemia]], [[hyperphosphatemia]], [[hyperuricemia]], [[hypocalcemia]], and [[acute renal failure]]. | In [[medicine]] ([[oncology]] and [[hematology]]), '''tumor lysis syndrome''' ('''TLS''') is a group of [[metabolism|metabolic]] complications that can occur after treatment of [[cancer]], usually [[lymphoma]]s and [[leukemia]]s, and sometimes even without treatment. These complications are caused by the break-down products of dying cancer cells and include [[hyperkalemia]], [[hyperphosphatemia]], [[hyperuricemia]], [[hypocalcemia]], and [[acute renal failure]]. | ||
==Classification== | |||
Tumor lysis syndrome (TLS) may be classified according to the 1993 Hande-Garrow classification system into two groups: laboratory tumor lysis syndrome (LTLS) and clinical tumor lysis syndrome (CTLS).<ref name="pmid15384972">{{cite journal| author=Cairo MS, Bishop M| title=Tumour lysis syndrome: new therapeutic strategies and classification. | journal=Br J Haematol | year= 2004 | volume= 127 | issue= 1 | pages= 3-11 | pmid=15384972 | doi=10.1111/j.1365-2141.2004.05094.x | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15384972 }} </ref> | |||
==Pathophysiology== | |||
Development of tumor lysis syndrome is the result of initiation of [[chemotherapy]] or [[radiotherapy]] in cancer patients. | |||
==References== | ==References== |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
In medicine (oncology and hematology), tumor lysis syndrome (TLS) is a group of metabolic complications that can occur after treatment of cancer, usually lymphomas and leukemias, and sometimes even without treatment. These complications are caused by the break-down products of dying cancer cells and include hyperkalemia, hyperphosphatemia, hyperuricemia, hypocalcemia, and acute renal failure.
Classification
Tumor lysis syndrome (TLS) may be classified according to the 1993 Hande-Garrow classification system into two groups: laboratory tumor lysis syndrome (LTLS) and clinical tumor lysis syndrome (CTLS).[1]
Pathophysiology
Development of tumor lysis syndrome is the result of initiation of chemotherapy or radiotherapy in cancer patients.
References
- ↑ Cairo MS, Bishop M (2004). "Tumour lysis syndrome: new therapeutic strategies and classification". Br J Haematol. 127 (1): 3–11. doi:10.1111/j.1365-2141.2004.05094.x. PMID 15384972.