Tumor lysis syndrome history and symptoms: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
Line 6: Line 6:


==History and Symptoms==
==History and Symptoms==
[[Hyperkalemia]]. [[Potassium]] is mainly an [[intracellular]] [[ion]]. High turnover of tumor cells leads to spill of potassium into the blood. Symptoms usually do not manifest until levels are high (> 7mmol/dL) [normal 3.5-5.0 mmol/dL] and they include
* severe muscle weakness or paralysis
* [[heart|cardiac]] conduction abnormalities (can be fatal)
'''[[Hyperphosphatemia]]'''. Like potassium, [[phosphate]]s are also predominantly intracellular. Hyperphosphatemia causes acute [[kidney|renal]] failure in tumor lysis syndrome, because of deposition of [[calcium phosphate]] crystals in the renal [[parenchyma]].
'''[[Hypocalcemia]]'''. Because of the hyperphosphatemia, [[calcium]] is precipitated to form calcium phosphate, leading to hypocalcemia. Symptoms of hypocalcemia include (but are not limited to):
Symptoms of tumor lysis syndrome include:<ref name="cancer.ca">Canadian Cancer Society.2015.http://www.cancer.ca/en/cancer-information/diagnosis-and-treatment/managing-side-effects/tumour-lysis-syndrome/?region=ab#symptoms</ref>
Symptoms of tumor lysis syndrome include:<ref name="cancer.ca">Canadian Cancer Society.2015.http://www.cancer.ca/en/cancer-information/diagnosis-and-treatment/managing-side-effects/tumour-lysis-syndrome/?region=ab#symptoms</ref>


Line 46: Line 36:
:*[[Anuria]]
:*[[Anuria]]
:*[[Somnolence]]
:*[[Somnolence]]
* [[Seizure]]
* Mental retardation / [[dementia]]
* Parkinsonian (extrapyramidal) movement disorders
* [[Papilledema]]
* Emotional instability / [[agitation]] / [[anxiety]]
*[[Delirium]]
*[[Hallucinations]]
*[[Myopathy]]
*[[Nausea]]
*[[Vomiting]]
*[[Diarrhea]]
*[[Oliguria]]
'''[[Hyperuricemia]]'''. [[Uric acid]] is a breakdown product of [[DNA]], converted by [[xanthine oxidase]] from [[xanthine]] and [[hypoxanthine]], which are in turn [[purine]] breakdown products. Uric acid is more toxic to tissues than (hypo)xanthine. Uric acid [[nephropathy]] has been a dominant cause of acute renal failure but with the advent of [[allopurinol]] and uricase treatment, hyperphosphatemia has replaced this as the main cause of acute renal failure. Oddly, [[gout]] is not a feature of tumor lysis syndrome; the high uric acid levels that cause gout probably need to be present for an extended period of time before the putative crystals can develop.


==References==
==References==

Revision as of 18:46, 23 September 2015

Tumor lysis syndrome Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Tumor lysis syndrome from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Criteria

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

Chest X Ray

CT

MRI

Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Tumor lysis syndrome history and symptoms On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Tumor lysis syndrome history and symptoms

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Tumor lysis syndrome history and symptoms

CDC on Tumor lysis syndrome history and symptoms

Tumor lysis syndrome history and symptoms in the news

Blogs on Tumor lysis syndrome history and symptoms

Directions to Hospitals Treating Tumor lysis syndrome

Risk calculators and risk factors for Tumor lysis syndrome history and symptoms

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Mohamad Alkateb, MBBCh [2]

Overview

Symptoms of tumor lysis syndrome include nausea, vomiting, diarrhea, oliguria, confusion, delirium, and seizure.

History and Symptoms

Symptoms of tumor lysis syndrome include:[1]


References

  1. ↑ Canadian Cancer Society.2015.http://www.cancer.ca/en/cancer-information/diagnosis-and-treatment/managing-side-effects/tumour-lysis-syndrome/?region=ab#symptoms

Template:WH Template:WS

Retrieved from "https://www.wikidoc.org/index.php?title=Tumor_lysis_syndrome_history_and_symptoms&oldid=1161379"