Tuberous sclerosis history and symptoms
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
History and Symptoms
- Skin problems, such as light patches and thickened skin
- Seizures
- Behavior problems
- Learning disabilities - seen in 50% patients ranging from mild to profound,[1] and studies have reported that between 25% and 61% of affected individuals meet the diagnostic criteria for autism, with an even higher proportion showing features of a broader pervasive developmental disorder.[2]
- Mental retardation
- Kidney problems
Most of the neurologic manifestations of tuberous sclerosis are due to the effects of hamartia (malformed tissue such as the cortical tubers),hamartomas (benign growths such as facial angiofibroma and subependymal nodules) and, very rarely, cancerous hamartoblastomas on the brain tissue.
In infants, the first clue is often the presence of seizures, delayed development or white patches on the skin. A full clinical diagnostic workup should be undertaken in such situations.[3][4]
References
- ↑ Ridler K; et al. (2006). "Neuroanatomical Correlates of Memory Deficits in Tuberous Sclerosis Complex". Cerebral Cortex. PMID 16603714.
- ↑ Harrison JE, Bolton, PF (1997). "Annotation: Tuberous sclerosis". Journal of Child Psychology and Psychiatry. 38: 603–614. PMID 9315970.
- ↑ "Tuberous Sclerosis Fact Sheet". National Institute of Neurological Disorders and Stroke. 2006-04-11. Retrieved 2006-10-03. Check date values in:
|date=(help) - ↑ "Summary of Clinical guidelines for the care of patients with Tuberous Sclerosis Complex" (PDF). Tuberous Sclerosis Association. 2002. Retrieved 2006-10-03. Unknown parameter
|month=ignored (help)