Tropical sprue pathophysiology

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

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Overview

Pathophysiology

Histology

The histological changes of TS include: Flattening of the villi and small intestinal inflammation which are similar to an autoimmune disorder Coeliac disease (also known as coeliac sprue). A complete flattening of the villi on small bowel biopsy is an uncommon finding in TS unlike Celiac disease.

Diagnosis Villous morphology Findings in Lamina propria Involved portion of the GI tract
Tropical sprue Mild to moderate blunting of the villi with an increased number of Intraepithelial lymphocytes. Increased number of plasma cells and eosinophils. Ileum > Duodenum > Colon
Celiac sprue Variable, often there is a complete flattening of the villi. Always there is an increased number of Intraepithelial lymphocytes Plasma cells > Eosinophils > Neutrophils. Duodenum > Ileum.

References

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