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| | | #REDIRECT [[Triptorelin pamoate]] |
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| {{drugbox |
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| | image = Triptorelin.svg
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| | CAS_number = 57773-63-4
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| | ATC_prefix = L02
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| | ATC_suffix =AE04
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| | C=64 | H=82| N=18| O=13|
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| | molecular_weight = 1311.5 g/mol
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| | excretion = [[Kidney|Renal]]
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| | pregnancy_category = D
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| | legal_status = ℞-only
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| | routes_of_administration = [[implant (medicine)|Implant]]
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| }}
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| {{SI}}
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| '''Triptorelin''' (acetate or palmoate) is a [[gonadotropin]] releasing [[hormone]] [[agonist]] (GnRH agonist). By causing constant stimulation of the [[pituitary gland|pituitary]], it decreases pituitary secretion of gonadotropins [[luteinizing hormone]] (LH) and [[follicle stimulating hormone]] (FSH). Like other GnRH agonists, triptorelin may be used in the treatment of hormone-responsive cancers such as [[prostate cancer]] or [[breast cancer]], [[precocious puberty]], [[estrogen]]-dependent conditions (such as [[endometriosis]] or [[uterine fibroids]]), and in [[Reproductive technology|assisted reproduction]]. Triptorelin is marketed under the brand names '''Decapeptyl'''<sup>®</sup> (''[[Ferring Pharmaceuticals]]'') and ''' Diphereline'''<sup>®</sup> and '''Gonapeptyl'''<sup>®</sup>.<br /> Triptorelin is sold by Pfizer in the United States as ''' Trelstar'''<sup>®</sup>.
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| During the treatment of [[prostate cancer]] it does cause a surge of [[testosterone]] (an initial uplevel of testosterone levels). In men a reduction of serum testosterone levels into the range normally seen after surgical castration occurs appr. 2 to 4 weeks after initiation of therapy. In contrast [[gonadotropin]] releasing [[hormone]] [[Receptor antagonist]]s does not cause a surge, but a sudden shut-down of [[testosterone]] level.<br />
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| Systematic IUPAC Name: [d-Trp6]GnRH
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| == References ==
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| * ''Pharmacokinetics and pharmacodynamics of GnRH agonists: clinical implications in pediatrics.'' J Pediatr Endocrinol Metab. 2000 Jul;13 Suppl 1:723-37. Review. PMID 10969915
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| * ''GnRH analogues—agonists and antagonists'' A.M. Padula,
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| University of Melbourne [http://dx.doi.org/10.1016/j.anireprosci.2005.05.005]
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| {{Sex hormones}}
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| [[Category:GnRH agonists]]
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| [[Category:Endocrinology]]
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