Trioxsalen

Jump to navigation Jump to search
Template:Chembox E number
Trioxsalen
Names
IUPAC name
2,5,9-trimethyl-7H-furo[3,2-g]chromen-7-one
Identifiers
3D model (JSmol)
ChEBI
ChEMBL
ChemSpider
DrugBank
ECHA InfoCard Lua error in Module:Wikidata at line 879: attempt to index field 'wikibase' (a nil value). Lua error in Module:Wikidata at line 879: attempt to index field 'wikibase' (a nil value).
KEGG
UNII
Properties
C14H12O3
Molar mass 228.24328
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
☒N verify (what is ☑Y☒N ?)
Infobox references


WikiDoc Resources for Trioxsalen

Articles

Most recent articles on Trioxsalen

Most cited articles on Trioxsalen

Review articles on Trioxsalen

Articles on Trioxsalen in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on Trioxsalen

Images of Trioxsalen

Photos of Trioxsalen

Podcasts & MP3s on Trioxsalen

Videos on Trioxsalen

Evidence Based Medicine

Cochrane Collaboration on Trioxsalen

Bandolier on Trioxsalen

TRIP on Trioxsalen

Clinical Trials

Ongoing Trials on Trioxsalen at Clinical Trials.gov

Trial results on Trioxsalen

Clinical Trials on Trioxsalen at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Trioxsalen

NICE Guidance on Trioxsalen

NHS PRODIGY Guidance

FDA on Trioxsalen

CDC on Trioxsalen

Books

Books on Trioxsalen

News

Trioxsalen in the news

Be alerted to news on Trioxsalen

News trends on Trioxsalen

Commentary

Blogs on Trioxsalen

Definitions

Definitions of Trioxsalen

Patient Resources / Community

Patient resources on Trioxsalen

Discussion groups on Trioxsalen

Patient Handouts on Trioxsalen

Directions to Hospitals Treating Trioxsalen

Risk calculators and risk factors for Trioxsalen

Healthcare Provider Resources

Symptoms of Trioxsalen

Causes & Risk Factors for Trioxsalen

Diagnostic studies for Trioxsalen

Treatment of Trioxsalen

Continuing Medical Education (CME)

CME Programs on Trioxsalen

International

Trioxsalen en Espanol

Trioxsalen en Francais

Business

Trioxsalen in the Marketplace

Patents on Trioxsalen

Experimental / Informatics

List of terms related to Trioxsalen

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Trioxsalen (trimethylpsoralen, Trioxysalen or Trisoralen) is a furanocoumarin and a psoralen derivative. It is obtained from several plants, mainly Psoralea corylifolia. Like other psoralens it causes photosensitization of the skin. It is administered either topically or orally in conjunction with UV-A (the least damaging form of ultraviolet light) for phototherapy treatment of vitiligo[1] and hand eczema.[2] After photoactivation it creates interstrand cross-links in DNA, which can cause programmed cell death unless repaired by cellular mechanisms. In research it can be conjugated to dyes for confocal microscopy and used to visualize sites of DNA damage.[3] The compound is also being explored for development of antisense oligonucleotides that can be cross-linked specifically to a mutant mRNA sequence without affecting normal transcripts differing at even a single base pair.[4]

References

  1. "Trioxsalen - Compound Summary". PubChem.
  2. Van Coevorden, AM; Kamphof, WG; Van Sonderen, E; Bruynzeel, DP; Coenraads, PJ (2004). "Comparison of oral psoralen-UV-A with a portable tanning unit at home vs hospital-administered bath psoralen-UV-A in patients with chronic hand eczema: an open-label randomized controlled trial of efficacy". Archives of dermatology. 140 (12): 1463–6. doi:10.1001/archderm.140.12.1463. PMID 15611423.
  3. Thazhathveetil, AK; Liu, ST; Indig, FE; Seidman, MM (2007). "Psoralen conjugates for visualization of genomic interstrand cross-links localized by laser photoactivation". Bioconjugate chemistry. 18 (2): 431–7. doi:10.1021/bc060309t. PMID 17373769.
  4. Higuchi, M; Yamayoshi, A; Kobori, A; Yamaoka, T; Murakami, A (2005). "Synthesis and properties of photo-reactive antisense oligonucleotides containing 2'-O-psoralen-conjugated adenosine". Nucleic acids symposium series (2004). 49 (49): 331–2. doi:10.1093/nass/49.1.331. PMID 17150768.


Template:Antipsoriatics