Tricuspid regurgitation differential diagnosis: Difference between revisions

Jump to navigation Jump to search
 
Line 23: Line 23:
*[[Left ventricular function]] can be assessed by determining the [[apical impulse]].  
*[[Left ventricular function]] can be assessed by determining the [[apical impulse]].  
*A normal or hyperdynamic [[apical impulse]] suggests good [[ejection fraction]] and primary [[mitral regurgitation]].  
*A normal or hyperdynamic [[apical impulse]] suggests good [[ejection fraction]] and primary [[mitral regurgitation]].  
*A displaced and sustained [[apical impulse]] suggests decreased [[ejection fraction]] and chronic and severe [[mitral regurgitation]].
|
*The [[holosystolic murmur]] can be best heard over the left third and fourth intercostal spaces and along the sternal border.
*When the shunt becomes reversed ([[Eisenmenger's syndrome]]), the murmur may be absent and S<sub>2</sub> can become markedly accentuated and single.
|
*Severe TR has been documented to mimic some hemodynamic findings in [[constrictive pericarditis]], with [[right heart catheterization]] demonstrating a constrictive physiology. [[Echocardiography]], CT thorax, and [[cardiac MRI]] are useful for ruling out [[pericardium|pericardial]] pathology.
|}
{| border="1"
|- style="padding: 0 5px; font-size: 100%; " align="center"
|'''Tricuspid Regurgitation'''
|'''Mitral Regurgitation'''
|'''VSD'''
|'''Constrictive Pericarditis'''<ref name="pmid24995118" />
|- style="font-size: 100; padding: 0 5px;"
|
*Can be best heard over the fourth intercostal area at [[left sternal border]].
*The intensity can be accentuated following [[inspiration]] ([[Carvallo's sign]]) due to increased regurgitant flow in [[right ventricular]] volume.
*Tricuspid regurgitation is most often secondary to [[pulmonary hypertension]].
*Primary tricuspid regurgitation is less common and can be due to bacterial [[endocarditis]] following [[IV drug use]], [[Ebstein's anomaly]], [[carcinoid disease]], or prior [[right ventricular infarction]].
|
*The [[murmur]] in [[mitral regurgitation]] is high pitched and best heard at the [[apex]] with diaphragm of the [[stethoscope]] with patient in the lateral decubitus position.
*[[Left ventricular function]] can be assessed by determining the [[apical impulse]].
*A normal or hyperdynamic [[apical impulse]] suggests good [[ejection fraction]] and primary [[mitral regurgitation]].
*A displaced and sustained [[apical impulse]] suggests decreased [[ejection fraction]] and chronic and severe [[mitral regurgitation]].
*A displaced and sustained [[apical impulse]] suggests decreased [[ejection fraction]] and chronic and severe [[mitral regurgitation]].
|
|
Line 54: Line 30:
*Severe TR has been documented to mimic some hemodynamic findings in [[constrictive pericarditis]], with [[right heart catheterization]] demonstrating a constrictive physiology. [[Echocardiography]], CT thorax, and [[cardiac MRI]] are useful for ruling out [[pericardium|pericardial]] pathology.
*Severe TR has been documented to mimic some hemodynamic findings in [[constrictive pericarditis]], with [[right heart catheterization]] demonstrating a constrictive physiology. [[Echocardiography]], CT thorax, and [[cardiac MRI]] are useful for ruling out [[pericardium|pericardial]] pathology.
|}<br />
|}<br />
{| class="wikitable"
! rowspan="2" |Diseases
! rowspan="2" |History
! rowspan="2" |Symptoms
! rowspan="2" |Physical Examination
! rowspan="2" |Murmur
! colspan="4" |Diagnosis
! rowspan="2" |Other Findings
|- style="background: #DCDCDC; padding: 5px; text-align: center;"
!ECG
!CXR
!Echocardiogram
!Cardiac Catheterization
|-
| style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Mitral Stenosis]]
| style="vertical-align: top;background: #F5F5F5; padding: 5px;" |
*Age ( Mitral annular calcification in older patients)
*[[Rheumatic fever]]
*[[Endocarditis]]
| style="vertical-align: top;background: #F5F5F5; padding: 5px;" |
*[[Dyspnea on exertion]]
*[[Paroxysmal nocturnal dyspnea]]
*[[Orthopnea]]
*New onset [[atrial fibrillation]]
| style="vertical-align: top;background: #F5F5F5; padding: 5px;" |
*Mitral facies
*Heart murmur
*[[JVD|Jugular vein distension]]
*Apical impulse displaced laterally or not palpable
*Diastolic thrill  at the apex
*Signs of heart failure in severe cases
| style="vertical-align: top;background: #F5F5F5; padding: 5px;" |
*Diastolic murmur
*Low pitched
*Opening snap  followed by decrescendo-crescendo rumbling murmur
*Best heard with the bell of the stethoscope at apex at end-expiration in left lateral decubitus position
*Intensity increases after a [[valsalva maneuver]], after exercise and after increased after load (eg., squatting, isometric hand grip)
| style="vertical-align: top;background: #F5F5F5; padding: 5px;" |
*[[P mitrale]]
*[[Atrial  fibrillation]]: No P waves and irregularly irregular rhythm
*[[Right axis deviation]]
*Right ventricular hypertropy: Dominant R wave in V1 and V2
| style="vertical-align: top;background: #F5F5F5; padding: 5px;" |
*Straightening of the left border of the heart suggestive of enlargement of the [[left atrium]]
*Double right heart border (Enlarged left atrium and normal right atrium)
*Prominent left atrial appendage
*Splaying of [[Carina|subcarinal angle]] (>120 degrees)
*Calcification of [[mitral valve]]
*[[Kerley B lines]]
| style="vertical-align: top;background: #F5F5F5; padding: 5px;" |
*Reduced valve leaflet mobility
*Valve calcification
*Doming of mitral valve
*Valve thickening
*Enlargement of left atrium
| style="vertical-align: top;background: #F5F5F5; padding: 5px;" |'''Right heart catheterization:'''
*[[Pulmonary capillary wedge pressure]] (left atrial pressure)
'''Left heart catheterization:'''
*Pressures in left ventricle
*Determines the gradient between the left and right atrium during ventricular diastole (marker of the severity of mitral stenosis)
| style="vertical-align: top;background: #F5F5F5; padding: 5px;" |
*[[Hemoptysis]] ([[heart failure]])
*[[Ortner's syndrome]]
|-
| colspan="10" |
|-
| style="vertical-align: top;background: #DCDCDC; padding: 5px; text-align: center;" |[[Mitral Regurgitation]]
| style="vertical-align: top;background: #F5F5F5; padding: 5px;" |
*[[CAD]]
*[[MI]]
*[[Rheumatic fever]]
*[[Endocarditis]]
*[[Mitral valve prolapse]]
*[[Cardiomyopathy]]
*[[Radiation therapy]]
*Trauma
| style="vertical-align: top;background: #F5F5F5; padding: 5px;" |
*[[Palpitations]]
*Symptoms of heart failure in severe cases
| style="vertical-align: top;background: #F5F5F5; padding: 5px;" |'''Palpation'''
*Brisk carotid upstroke and hyperdymanic carotid impulse on palpation
*Apical impulse is displaced to left
*S3 and a palpable thrill
'''Auscultation'''
*Murmur
| style="vertical-align: top;background: #F5F5F5; padding: 5px;" |
*[[Holosystolic murmur]]
*High pitched, blowing
*Radiates to axilla
*Best heard with the diaphragm of the stethoscope at apex in left lateral [[decubitus]] position
*Intensity increases with hand grip or squatting
*Decrease in intensity on standing or [[valsalva maneuver]]
| style="vertical-align: top;background: #F5F5F5; padding: 5px;" |
*[[P mitrale]] in lead II
*Increased QRS voltage
*[[Right axis deviation]]
*[[Atrial fibrillation]]
| style="vertical-align: top;background: #F5F5F5; padding: 5px;" |'''Acute MR'''
*[[Kerley B lines]]
*No enlargement of cardiac silhouette
'''Chronic MR'''
*Enlarged cardiac silhouette
*Straightening of left heart border
*Splaying of subcarinal angle
*Calcification of mitral annulus
*Double right heart border
| style="vertical-align: top;background: #F5F5F5; padding: 5px;" |
*Enlargement of left atrium and ventricle
*Identify valve abnormality
*Valve calcification
*Severity of regurgitation
| style="vertical-align: top;background: #F5F5F5; padding: 5px;" |
*Grading of MR is done with left ventriculography
| style="vertical-align: top;background: #F5F5F5; padding: 5px;" |
*Decompensated and acute MR may lead to [[heart failure]]
|-
| colspan="10" |
|-
| style="vertical-align: top;background: #DCDCDC; padding: 5px; text-align: center;" |[[Atrial septal defect]]
| style="vertical-align: top;background: #F5F5F5; padding: 5px;" |
*Frequent respiratory or lung infections
*[[Dyspnea]]
*Tiring when feeding (Infants)
*Shortness of breath on exertion
*[[Palpitations]]
*Swelling of feet
| style="vertical-align: top;background: #F5F5F5; padding: 5px;" |
*[[Shortness of breath]]
*[[Fatigue]]
*[[Failure to thrive]]
*Swelling of feet and abdomen ([[Right heart failure]])
*[[Palpitations]]
*Respiratory infections
| style="vertical-align: top;background: #F5F5F5; padding: 5px;" |'''Inspection'''
*Precordial bulge
*Precordial lift
'''Palpation'''
*Right ventricular impulse
*Pulmonary artery pulsations
*Thrill
'''Auscultation'''
*Murmur
| style="vertical-align: top;background: #F5F5F5; padding: 5px;" |
*Midsystolic (ejection systolic) murmur
*Widely split, fixed S2
*Upper left sternal border
| style="vertical-align: top;background: #F5F5F5; padding: 5px;" |
*Normal
*Prolonged PR interval
*[[Right bundle branch block]]
*ECG findings varies according to the underlying type of ASD
| style="vertical-align: top;background: #F5F5F5; padding: 5px;" |
*Increased pulmonary markings
*[[Cardiomegaly]]
*Triangular appearance of heart
*Schimitar sign
| style="vertical-align: top;background: #F5F5F5; padding: 5px;" |
*Gold standard test for diagnosis of atrial septal defect  (for more information click [[Atrial septal defect echocardiography]])
| style="vertical-align: top;background: #F5F5F5; padding: 5px;" |
*Defect size
*Pulmonary venous return
*[[Pulmonary vascular resistance]]
*[[Pulmonary artery hypertension]]
| style="vertical-align: top;background: #F5F5F5; padding: 5px;" |
*Asymptomatic until later part of their life
*May be associated with [[migraine with aura]]
|-
| colspan="10" |
|-
| style="vertical-align: top;background: #DCDCDC; padding: 5px; text-align: center;" |[[Atrial myxoma|Left Atrial Myxoma]]
| style="vertical-align: top;background: #F5F5F5; padding: 5px;" |
*[[Dyspnea]]
*[[Orthopnea]]
*[[Pulmonary edema]]
*Hyperpigmentation of skin and endocrine activity
*Cerebral [[embolism]]
| style="vertical-align: top;background: #F5F5F5; padding: 5px;" |
*Symptoms may mimic mitral stenosis
| style="vertical-align: top;background: #F5F5F5; padding: 5px;" |'''Skin'''
*Signs of an embolic phenomenon
*[[Raynaud's phenomenon]]
*Swelling
*Clubbing
'''Auscultation:'''
*Lung: Fine crepitations
*Heart: Characteristic "tumor plop"
| style="vertical-align: top;background: #F5F5F5; padding: 5px;" |
*Early diastolic sound as "tumor plop"
*Low frequency diastolic murmur may be heard if the tumor obstructing mitral valve
| style="vertical-align: top;background: #F5F5F5; padding: 5px;" |
*Often normal
| style="vertical-align: top;background: #F5F5F5; padding: 5px;" |
*Often normal
'''Rare findings:'''
*[[cardiomegaly]]
*Left atrial enlargement
*tumor calcification etc.,
| style="vertical-align: top;background: #F5F5F5; padding: 5px;" |
*Initial and most useful diagnostic study
*For more information click [[Myxoma echocardiography or ultrasound]]
| style="vertical-align: top;background: #F5F5F5; padding: 5px;" |
*Useful to detect vascular supply of the tumor by the coronary arteries
| style="vertical-align: top;background: #F5F5F5; padding: 5px;" |
*Associated with Carney complex (genetic predisposition)
|-
| colspan="10" |
|-
| style="vertical-align: top;background: #DCDCDC; padding: 5px; text-align: center;" |Prosthetic Valve Obstruction
| style="vertical-align: top;background: #F5F5F5; padding: 5px;" |
*History of valve replacement
*Systemic embolism
| style="vertical-align: top;background: #F5F5F5; padding: 5px;" |
*Shortness of breath
*Fatigue
| style="vertical-align: top;background: #F5F5F5; padding: 5px;" |'''Ausculation'''
Muffling of murmur
| style="vertical-align: top;background: #F5F5F5; padding: 5px;" |
*Muffling or disappearance of prosthetic sounds
*Appearance of new regurgitant or obstructive murmur
| style="vertical-align: top;background: #F5F5F5; padding: 5px;" |
| style="vertical-align: top;background: #F5F5F5; padding: 5px;" |
| style="vertical-align: top;background: #F5F5F5; padding: 5px;" |
*Degree of stenosis
*Assess thrombus size and location
*Differentiate between thrombus, [[pannus]] and vegetations
| style="vertical-align: top;background: #F5F5F5; padding: 5px;" |
| style="vertical-align: top;background: #F5F5F5; padding: 5px;" |Causes:
*Thrombus
*Pannus formation
|-
| colspan="10" |
|-
| style="vertical-align: top;background: #DCDCDC; padding: 5px; text-align: center;" |[[Cor Triatriatum]]
| style="vertical-align: top;background: #F5F5F5; padding: 5px;" |
*Dyspnea on exertion
*Recent onset of [[congestive heart failure]]
| style="vertical-align: top;background: #F5F5F5; padding: 5px;" |
*Dsypnea on exertion
*Orthopnea
*Tachypnea
*Palpitations
*Growth failure
| style="vertical-align: top;background: #F5F5F5; padding: 5px;" |'''Auscultation'''
*Murmur
'''Other findings'''
*Signs of heart failure
| style="vertical-align: top;background: #F5F5F5; padding: 5px;" |
*Diastolic murmur with loud P2
*No opening snap or a loud S1
| style="vertical-align: top;background: #F5F5F5; padding: 5px;" |Non specific but may have
*[[Right axis deviation]]
*Right atrial enlargement
*[[Right ventricular hypertrophy]]
| style="vertical-align: top;background: #F5F5F5; padding: 5px;" |
*Normal cardiac silhouette
*Hemodynamic changes similar to mitral stenosis (non specific findings)
| style="vertical-align: top;background: #F5F5F5; padding: 5px;" |
*Direct visualization of membrane through the atrium
*+/- visualization of accessory chamber
| style="vertical-align: top;background: #F5F5F5; padding: 5px;" |
*Normal left ventricular hemodynamic profile with a trans atrial gradient
| style="vertical-align: top;background: #F5F5F5; padding: 5px;" |Types
*Cor triatriatum sinistrum
*Cor triatriatum dextrum
|-
| colspan="10" |
|-
| style="vertical-align: top;background: #DCDCDC; padding: 5px; text-align: center;" |Congenital Mitral Stenosis
| style="vertical-align: top;background: #F5F5F5; padding: 5px;" |
*Respiratory distress shortly after birth
*Recurrent severe pulmonary infections
*Other associated congenital cardiovascular anamolies
*[[Atrial fibrillation]]
| style="vertical-align: top;background: #F5F5F5; padding: 5px;" |'''Infants:'''
*Exhaustion and sweating on feeding
*Rapid breathing
*[[Failure to thrive]]
*Pulmonary infections
*Chronic cough
'''Older patients:'''
*Dyspnea
*Orthopnea
*Paroxysmal nocturnal dyspnea
*Peripheral edema
*Fatigue
| style="vertical-align: top;background: #F5F5F5; padding: 5px;" |'''Auscultation'''
*Murmur
'''Other findings'''
*Signs of heart failure
| style="vertical-align: top;background: #F5F5F5; padding: 5px;" |'''Mild-Moderate'''
*Loud S1
*Loud P2
*Low frequency diastolic murmur best heard at the apex
'''Severe'''
*Soft S1
*Loud pulmonic component of S2 with minimal respiratory splitting of S2
*Holodiastolic murmur with presystolic accentuation best heard at the apex
*Early diastolic murmur of pulmonic valve regurgitation
| style="vertical-align: top;background: #F5F5F5; padding: 5px;" |
*Sharp P waves in leads I and II
*Inversion of P wave in lead III
*Marked Q waves in leads II and III
| style="vertical-align: top;background: #F5F5F5; padding: 5px;" |
*Left atrial dilation
*Moderate enlargement of right heart
*Pulmonary venous congestion
*Esophageal compression
| style="vertical-align: top;background: #F5F5F5; padding: 5px;" |
*Reduced valve leaflet mobility
*Left atrial size
*Severity of mitral stenosis
| style="vertical-align: top;background: #F5F5F5; padding: 5px;" |
| style="vertical-align: top;background: #F5F5F5; padding: 5px;" |Very rare condition
|-
| colspan="10" |
|-
| style="vertical-align: top;background: #DCDCDC; padding: 5px; text-align: center;" |Supravalvular Ring Mitral Stenosis
| style="vertical-align: top;background: #F5F5F5; padding: 5px;" |
*Other associated congenital heart defects
*Fatigue
*Frequent respiratory infections
*Failure to thrive
*Poor feeding
*Precocious congestive heart failure
| style="vertical-align: top;background: #F5F5F5; padding: 5px;" |
*Shortness of breath
*Tachypnea
*Dyspnea
*Nocturnal cough
*Heamoptysis
*[[Syncope]]
| style="vertical-align: top;background: #F5F5F5; padding: 5px;" |'''Auscultation:'''
Lungs: Fine, crepitant rales and rhonchi or wheezes may be present
Heart: Murmur
| style="vertical-align: top;background: #F5F5F5; padding: 5px;" |
*An apical mid diastolic murmur with presystolic accentuation
*No opening snap
*The murmur is more prominent if associated with [[VSD]] or [[PDA]]
| style="vertical-align: top;background: #F5F5F5; padding: 5px;" |
| style="vertical-align: top;background: #F5F5F5; padding: 5px;" |
*Left atrial and ventricular enlargement
*Alveolar edema
| style="vertical-align: top;background: #F5F5F5; padding: 5px;" |'''Supramitral ring''':
*Associated with normal mitral valve apparatus
'''Intramitral ring:'''
*Hypomobility of the posterior leaflet
*Reduced interpapillary muscle distance
*Reduced chordal length
*Dominant papillary muscle
*Hypoplastic mitral annulus
(Difficult to visualize membrane <1mm in size)
| style="vertical-align: top;background: #F5F5F5; padding: 5px;" |
*Persistently elevated pulmonary venous pressures
*Increased pulmonary artery pressure
| style="vertical-align: top;background: #F5F5F5; padding: 5px;" |'''Types'''
*Supramitral
*Intramitral
It is attached between the opening of the atrial appendage and the mitral annulus which helps in differentiating with Cor triatriatum sinister.
*Intramitral type is associated with shone complex
|}
==References==
==References==
{{Reflist|2}}
{{Reflist|2}}

Latest revision as of 17:52, 21 January 2020

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Fatimo Biobaku M.B.B.S [2]

Overview

The blowing holosystolic murmur of tricuspid regurgitation must be distinguished from the murmur of mitral regurgitation and a ventricular septal defect.

Differentiating Tricuspid regurgitation from other Diseases

Tricuspid Regurgitation Mitral Regurgitation VSD Constrictive Pericarditis[1]
  • The holosystolic murmur can be best heard over the left third and fourth intercostal spaces and along the sternal border.
  • When the shunt becomes reversed (Eisenmenger's syndrome), the murmur may be absent and S2 can become markedly accentuated and single.


References

  1. Ozpelit E, Akdeniz B, Ozpelit ME, Göldeli O (2014). "Severe tricuspid regurgitation mimicking constrictive pericarditis". Am J Case Rep. 15: 271–4. doi:10.12659/AJCR.890092. PMC 4079647. PMID 24995118.

Template:WH Template:WS