Trichlormethiazide

Trichlormethiazide

Clinical data
AHFS/Drugs.com	Micromedex Detailed Consumer Information
Pregnancy category	B (D if used to treat pregnancy-induced hypertension)
Routes of administration	Oral (capsules, tablets, oral solution)
ATC code	C03AA03 (WHO)
Legal status
Legal status	In general: ℞ (Prescription only)
Pharmacokinetic data
Bioavailability	Variably absorbed from GI tract
Excretion	Primarily excreted unchanged in urine
Identifiers
IUPAC name 6-chloro-3-(dichloromethyl)-1,1-dioxo- 3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine- 7-sulfonamide
CAS Number	133-67-5 Y
PubChem CID	5560
DrugBank	DB01021 N
ChemSpider	5359 N
UNII	Q58C92TUN0
KEGG	D00658 N
ChEMBL	ChEMBL1054 N
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}
Chemical and physical data
Formula	C8H8Cl3N3O4S2
Molar mass	380.6558 g/mol
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Trichlormethiazide (currently being sold under the brand names of Achletin, Diu-Hydrin and Triflumen) is a diuretic with properties similar to those of hydrochlorothiazide. It is usually administered for the treatment of oedema (including that which is associated with heart failure, hepatic cirrhosis and corticosteroid therapy) and hypertension.

Pharmacology

As a diuretic (in particular a thiazide), Trichlormethiazide encourages water loss from the body. Trichlormethiazide works by inhibiting Na⁺/Cl^- ion reabsorption from the distal tubules of the kidneys. In addition, Trichlormethiazide increases the excretion of potassium.

Mechanism

Trichlormethiazide appears to block the active reabsorption of chloride and possibly sodium in the ascending loop of Henle. This results in excretion of sodium, chloride and water, and thus acts as a diuretic. Although Trichlormethiazide is used to treat hypertension, it's hypotensive effects may aren't necessarily due to their role as a diuretic. Thiazides in general cause vasodilation by activating calcium-activated potassium channels in vascular smooth muscles and inhibiting various carbonic anhydrases in vascular tissue.