Transcription elongation regulator 1

Transcription elongation regulator 1
File:PBB Protein TCERG1 image.jpg PDB rendering based on 1e0l.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1e0l​, 2dk7​, 2dod​, 2doe​, 2dof​, 2nnt​
Identifiers
Symbols	TCERG1 ; CA150; MGC133200; TAF2S
External IDs	Template:OMIM5 Template:MGI HomoloGene: 4879
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE TCERG1 202396 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Transcription elongation regulator 1, also known as TCERG1, is a human gene.

This gene encodes a nuclear protein that regulates transcriptional elongation and pre-mRNA splicing. The encoded protein interacts with the hyperphosphorylated C-terminal domain of RNA polymerase II via multiple FF domains, and with the pre-mRNA splicing factor SF1 via a WW domain. Alternative splicing results in multiple transcripts variants encoding different isoforms.

Further reading

• Suñé C, Hayashi T, Liu Y; et al. (1997). "CA150, a nuclear protein associated with the RNA polymerase II holoenzyme, is involved in Tat-activated human immunodeficiency virus type 1 transcription". Mol. Cell. Biol. 17 (10): 6029–39. PMID 9315662.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Neubauer G, King A, Rappsilber J; et al. (1998). "Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex". Nat. Genet. 20 (1): 46–50. doi:10.1038/1700. PMID 9731529.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Suñé C, Garcia-Blanco MA (1999). "Transcriptional cofactor CA150 regulates RNA polymerase II elongation in a TATA-box-dependent manner". Mol. Cell. Biol. 19 (7): 4719–28. PMID 10373521.
• Carty SM, Goldstrohm AC, Suñé C; et al. (2000). "Protein-interaction modules that organize nuclear function: FF domains of CA150 bind the phosphoCTD of RNA polymerase II". Proc. Natl. Acad. Sci. U.S.A. 97 (16): 9015–20. doi:10.1073/pnas.160266597. PMID 10908677.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bohne J, Cole SE, Suñe C; et al. (2000). "Expression analysis and mapping of the mouse and human transcriptional regulator CA150". Mamm. Genome. 11 (10): 930–3. PMID 11003711.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Holbert S, Denghien I, Kiechle T; et al. (2001). "The Gln-Ala repeat transcriptional activator CA150 interacts with huntingtin: neuropathologic and genetic evidence for a role in Huntington's disease pathogenesis". Proc. Natl. Acad. Sci. U.S.A. 98 (4): 1811–6. doi:10.1073/pnas.041566798. PMID 11172033.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Goldstrohm AC, Albrecht TR, Suñé C; et al. (2001). "The transcription elongation factor CA150 interacts with RNA polymerase II and the pre-mRNA splicing factor SF1". Mol. Cell. Biol. 21 (22): 7617–28. doi:10.1128/MCB.21.22.7617-7628.2001. PMID 11604498.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zhou Z, Licklider LJ, Gygi SP, Reed R (2002). "Comprehensive proteomic analysis of the human spliceosome". Nature. 419 (6903): 182–5. doi:10.1038/nature01031. PMID 12226669.CS1 maint: Multiple names: authors list (link)
• Carty SM, Greenleaf AL (2003). "Hyperphosphorylated C-terminal repeat domain-associating proteins in the nuclear proteome link transcription to DNA/chromatin modification and RNA processing". Mol. Cell Proteomics. 1 (8): 598–610. PMID 12376575.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chattopadhyay B, Ghosh S, Gangopadhyay PK; et al. (2003). "Modulation of age at onset in Huntington's disease and spinocerebellar ataxia type 2 patients originated from eastern India". Neurosci. Lett. 345 (2): 93–6. PMID 12821179.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Reuter TY, Medhurst AL, Waisfisz Q; et al. (2003). "Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport". Exp. Cell Res. 289 (2): 211–21. PMID 14499622.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Palancade B, Marshall NF, Tremeau-Bravard A; et al. (2004). "Dephosphorylation of RNA polymerase II by CTD-phosphatase FCP1 is inhibited by phospho-CTD associating proteins". J. Mol. Biol. 335 (2): 415–24. PMID 14672652.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nagel JE, Smith RJ, Shaw L; et al. (2005). "Identification of genes differentially expressed in T cells following stimulation with the chemokines CXCL12 and CXCL10". BMC Immunol. 5: 17. doi:10.1186/1471-2172-5-17. PMID 15296517.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Goehler H, Lalowski M, Stelzl U; et al. (2004). "A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease". Mol. Cell. 15 (6): 853–65. doi:10.1016/j.molcel.2004.09.016. PMID 15383276.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lin KT, Lu RM, Tarn WY (2004). "The WW domain-containing proteins interact with the early spliceosome and participate in pre-mRNA splicing in vivo". Mol. Cell. Biol. 24 (20): 9176–85. doi:10.1128/MCB.24.20.9176-9185.2004. PMID 15456888.CS1 maint: Multiple names: authors list (link)
• Smith MJ, Kulkarni S, Pawson T (2004). "FF domains of CA150 bind transcription and splicing factors through multiple weak interactions". Mol. Cell. Biol. 24 (21): 9274–85. doi:10.1128/MCB.24.21.9274-9285.2004. PMID 15485897.CS1 maint: Multiple names: authors list (link)
• Andersen JS, Lam YW, Leung AK; et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kimura K, Wakamatsu A, Suzuki Y; et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• McFie PJ, Wang GL, Timchenko NA; et al. (2006). "Identification of a co-repressor that inhibits the transcriptional and growth-arrest activities of CCAAT/enhancer-binding protein alpha". J. Biol. Chem. 281 (26): 18069–80. doi:10.1074/jbc.M512734200. PMID 16644732.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)