Thrombotic thrombocytopenic purpura diagnostic study of choice

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Saeedeh Kowsarnia M.D.[2]

Overview

Complete blood count (CBC) with platelet count

Review of the peripheral blood smear

Serum electrolytes and creatinine

Serum lactate dehydrogenase (LDH)

Serum bilirubin level

Coagulation testing ( PT, aPTT, fibrinogen, D-dimer)

Serum haptoglobin level

Direct antiglobulin (Coombs) test (DAT)

ADAMTS13 activity and inhibitor testing