Thrombophilia medical therapy

Thrombophilia Microchapters
Home
Patient Information
Overview
Historical Perspective
Classification
Pathophysiology
Causes
Differentiating Thrombophilia from other Diseases
Epidemiology and Demographics
Risk Factors
Screening
Natural History, Complications and Prognosis
Diagnosis
History and Symptoms
Physical Examination
Laboratory Findings
X Ray
CT
MRI
Ultrasound
Other Imaging Findings
Other Diagnostic Studies
Treatment
Medical Therapy
Surgery
Primary Prevention
Secondary Prevention
Cost-Effectiveness of Therapy
Future or Investigational Therapies
Case Studies
Case #1
Thrombophilia medical therapy On the Web
Most recent articles
Most cited articles
Review articles
CME Programs
Powerpoint slides
Images
American Roentgen Ray Society Images of Thrombophilia medical therapy All Images X-rays Echo & Ultrasound CT Images MRI
Ongoing Trials at Clinical Trials.gov
US National Guidelines Clearinghouse
NICE Guidance
FDA on Thrombophilia medical therapy
CDC on Thrombophilia medical therapy
Thrombophilia medical therapy in the news
Blogs on Thrombophilia medical therapy
Directions to Hospitals Treating Thrombophilia
Risk calculators and risk factors for Thrombophilia medical therapy

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Asiri Ediriwickrema, M.D., M.H.S. [2]

Overview

• The treatment for thrombophilia depends on the underlying hypercoagulable state and the clinical presentation.
• Treatment should be tailored to the individual patient.
  • The risks and benefits, required monitoring, and costs associated with each form of anticoagulation should be discussed with the patient prior to initiation of therapy.
• The mainstay of therapy for thrombophilia is anticoagulation with either warfarin, low molecular weight heparin, direct Xa inhibitors, or direct thrombin inhibitors.
• Response to anticoagulation can be monitored clinically, or with repeat ultrasongraphy for deep vein thrombosis or measuring D-dimer levels after treatment.

Medical Therapy

The treatment algorithms for various thrombophilias are presented below:

Management of acute thrombosis in patients with inherited thrombophilias

Management of asymptomatic patients with inherited thrombophilias

Management of patients with acquired thrombophilias

• Prophylactic anticoagulation should be used in the following scenarios:
  • Post surgery
  • Pregnancy and Postpartum