Thrombophilia differential diagnosis

Revision as of 18:56, 20 July 2016 by Asiri Saumya Ediriwickrema (talk | contribs) (update)
Jump to navigation Jump to search

Thrombophilia Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Thrombophilia from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

History and Symptoms

Physical Examination

Laboratory Findings

X Ray

CT

MRI

Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Thrombophilia differential diagnosis On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Thrombophilia differential diagnosis

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Thrombophilia differential diagnosis

CDC on Thrombophilia differential diagnosis

Thrombophilia differential diagnosis in the news

Blogs on Thrombophilia differential diagnosis

Directions to Hospitals Treating Thrombophilia

Risk calculators and risk factors for Thrombophilia differential diagnosis

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Asiri Ediriwickrema, M.D., M.H.S. [2]

Overview

Inherited thrombophilia must be differentiated from acquired thrombophilia, as it may influence the selection and duration of anticoagulation. Inherited thrombophilias should be suspected in patients with the certain clinical presentations.[1][2] Screening for inherited thrombophilias is controversial and should be performed in the appropriate clinical context.[3]

Differential Diagnosis

  • Inherited thrombophilia must be differentiated from acquired thrombophilia, as it may influence the selection and duration of anticoagulation
  • Inherited thrombophilias should be suspected in patients with the following clinical presentations:[1][2]
    • Family history of thrombosis, especially at an early age (< 45 years)
    • Unprovoked thrombosis at an early age (<40-55 for venous thrombosis and <50-55 for arterial thrombosis)
    • Recurrent thrombosis including Deep venous thrombosis, Pulmonary embolus, or superficial venous thrombosis
    • Thrombosis at multiple sites, or unusual locations including in cerebral, hepatic, portal, mesenteric, and renal veins
    • Thrombosis in arteries with the abscence of arterial disease
    • History of fetal loss
    • History of warfarin skin necrosis

References

  1. 1.0 1.1 Cohoon KP, Heit JA (2014). "Inherited and secondary thrombophilia". Circulation. 129 (2): 254–7. doi:10.1161/CIRCULATIONAHA.113.001943. PMC 3979345. PMID 24421360.
  2. 2.0 2.1 Seligsohn U, Lubetsky A (2001). "Genetic susceptibility to venous thrombosis". N Engl J Med. 344 (16): 1222–31. doi:10.1056/NEJM200104193441607. PMID 11309638.
  3. Middeldorp S (2011). "Evidence-based approach to thrombophilia testing". J Thromb Thrombolysis. 31 (3): 275–81. doi:10.1007/s11239-011-0572-y. PMC 3056012. PMID 21340752.

Template:WH Template:WS