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==Differential Diagnosis==
==Differential Diagnosis==
*Inherited thrombophilias should be suspected in following clinical presentations:  
*Inherited thrombophilias should be suspected in following clinical presentations<ref name=?>DeLoughery TG. Hemostasis and Thrombosis: Springer International Publishing; 2014.</ref>:  
**Family history of thrombosis, especially at an early age
**Family history of thrombosis, especially at an early age
**Unprovoked thrombosis at an early age (<40-55 for venous thrombosis and <50-55 for arterial thrombosis)
**Unprovoked thrombosis at an early age (<40-55 for venous thrombosis and <50-55 for arterial thrombosis)

Revision as of 21:03, 24 June 2016

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Asiri Ediriwickrema, M.D., M.H.S. [2]

Overview

  • Inherited thrombophilia must be differentiated from acquired thrombophilia, as it may influence the selection and duration of anticoagulation.
  • Inherited thrombophilias should be suspected in patients with the certain clinical presentations[1].
  • Screening for inherited thrombophilias is controversial and should be performed in the appropriate clinical context.

Differential Diagnosis

  • Inherited thrombophilias should be suspected in following clinical presentations[2]:
    • Family history of thrombosis, especially at an early age
    • Unprovoked thrombosis at an early age (<40-55 for venous thrombosis and <50-55 for arterial thrombosis)
    • Recurrent thrombosis
    • Thrombosis at multiple sites, or unusual locations including in cerebral, splanchnic, and renal veins.
    • Thrombosis in arteries with the abscence of arterial disease
    • History of fetal loss

References

  1. Cohoon KP, Heit JA (2014). "Inherited and secondary thrombophilia". Circulation. 129 (2): 254–7. doi:10.1161/CIRCULATIONAHA.113.001943. PMC 3979345. PMID 24421360.
  2. DeLoughery TG. Hemostasis and Thrombosis: Springer International Publishing; 2014.

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