Tetrazepam

Tetrazepam

Clinical data
Routes of administration	Oral
ATC code	M03BX07 (WHO)
Pharmacokinetic data
Elimination half-life	15 hours
Identifiers
IUPAC name 7-Chloro-5-(cyclohex-1-enyl)-1,3-dihydro-1-methyl-2H-1,4-benzodiazepin-2-one
CAS Number	10379-14-3
PubChem CID	25215
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}
Chemical and physical data
Formula	C16H17ClN2O
Molar mass	288.772

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Overview

Tetrazepam, (Clinoxan, Epsipam, Myolastan, Musaril, Relaxam, Spasmorelax) is a benzodiazepine derivative with anxiolytic and muscle relaxant properties. It is used mainly in Austria, France, Belgium and Germany to treat muscle spasm, anxiety disorders such as panic attacks, or more rarely to treat depression, premenstrual syndrome or agoraphobia. Tetrazepam has relatively little sedative effect at low doses while still producing useful muscle relaxation and anxiety relief.

The indicated adult dose for muscle spasm is 50 mg three to four times per day, increased if necessary to a maximum of 800mg per day, in divided doses. Tetrazepam is not generally recommended for use in children, except on the advice of a specialist.

Tetrazepam is only available in one strength and formulation, 50mg tablets. This dose is approximately equivalent to 5-7.5mg oral diazepam. Prolonged use, as with all benzodiazepines, should be avoided, as tolerance occurs and there is a risk of possible dependence and a benzodiazepine withdrawal syndrome after stopping or reducing dosage.