Testicular cancer pathophysiology: Difference between revisions

Jump to navigation Jump to search
No edit summary
No edit summary
Line 4: Line 4:


==Overview==
==Overview==
On microscopic histopathological analysis of testicular cancer, fried-egg appearance is the characteristic finding of [[seminoma]]; marked nuclear atypia is the characteristic finding of [[embryonal carcinoma]]; blander cytomorphology, hyaline-type globules, and schiller-Duval bodies are characteristic findings of [[yolk sac tumor ]]; both syncytiotrophoblasts and cytotrophoblast cells is the characteristic finding of [[choriocarcinoma]].


==Pathophysiology==
==Pathophysiology==

Revision as of 14:50, 19 October 2015

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Testicular cancer Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Testicular cancer from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Staging

History and Symptoms

Physical Examination

Laboratory Findings

X Ray

CT

MRI

Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Biopsy

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Testicular cancer pathophysiology On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Testicular cancer pathophysiology

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Testicular cancer pathophysiology

CDC on Testicular cancer pathophysiology

Testicular cancer pathophysiology in the news

Blogs on Testicular cancer pathophysiology

Directions to Hospitals Treating Testicular cancer

Risk calculators and risk factors for Testicular cancer pathophysiology

Overview

On microscopic histopathological analysis of testicular cancer, fried-egg appearance is the characteristic finding of seminoma; marked nuclear atypia is the characteristic finding of embryonal carcinoma; blander cytomorphology, hyaline-type globules, and schiller-Duval bodies are characteristic findings of yolk sac tumor ; both syncytiotrophoblasts and cytotrophoblast cells is the characteristic finding of choriocarcinoma.

Pathophysiology

  • More than 90% of all testicular cancers are germ cell tumors. This type of cancer starts in germ cells, which are the cells that make sperm.[1]
  • About 50% of all germ cell tumours are seminomas, or seminomatous germ cell tumours. They grow slower than non-seminomas.

Microscopic Pathology

Germ cell Tumors[2]

  • Seminoma
  • Clonal proliferation of neoplastic germ cells
  • Fried-egg appearance
  • Non-seminomas
  • Embryonal carcinoma[3]
  • Marked nuclear atypia
  • Yolk sac tumor[2]
  • Blander cytomorphology
  • Hyaline-type globules
  • Schiller-Duval bodies
  • Choriocarcinoma
  • Both syncytiotrophoblasts and cytotrophoblast cells

References

  1. Testicular cancer. Canadian Cancer Society 2015. http://www.cancer.ca/en/cancer-information/cancer-type/testicular/testicular-cancer/cancerous-tumours/?region=ab Accessed on October, 13 2015
  2. 2.0 2.1 Krag Jacobsen G, Barlebo H, Olsen J, Schultz HP, Starklint H, Søgaard H; et al. (1984). "Testicular germ cell tumours in Denmark 1976-1980. Pathology of 1058 consecutive cases". Acta Radiol Oncol. 23 (4): 239–47. PMID 6093440.
  3. Talerman A, Haije WG, Baggerman L (1980). "Serum alphafetoprotein (AFP) in patients with germ cell tumors of the gonads and extragonadal sites: correlation between endodermal sinus (yolk sac) tumor and raised serum AFP". Cancer. 46 (2): 380–5. PMID 6155988.


Template:WikiDoc Sources