Testicular cancer classification: Difference between revisions

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|'''Germ cell tumors derived from germ cell neoplasia in situ:'''
|'''Germ cell tumors derived from germ cell neoplasia in situ:'''
* Non-invasive germ cell neoplasia
* Non-invasive [[germ cell]] [[neoplasia]]
**Germ cell neoplasia in situ
**[[Germ cell]] [[neoplasia]] in situ
**Specific forms of intratubular germ cell tumor neoplasia
**Specific forms of intratubular germ cell tumor [[neoplasia]]
* Tumors of a single histological type (pure forms)
* Tumors of a single histological type (pure forms)
**[[Seminoma]]
**[[Seminoma]]
**[[Seminoma with syncytiotrophoblast cells]]
**[[Seminoma|Seminoma with syncytiotrophoblast cells]]
**[[Non-seminomatous germ cell tumors]]
**[[Non-seminomatous germ cell tumors]]
**[[Embryonal carcinoma]]
**[[Embryonal carcinoma]]

Revision as of 14:22, 24 May 2019

Testicular cancer Microchapters

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Gertrude Djouka, M.D.[2], Shanshan Cen, M.D. [3]

Overview

Testicular cancer is a very rare type of cancer. Based on the histopathological features, testicular cancer may be classified into six subtypes: germ cell tumors, sex-cord stromal tumors, tumors containing both germ cell and sex-cord stromal elements, miscellaneous tumors of the testis, hematolymphoid tumors, and tumors of collecting duct and rete testis.

Classification

WHO Classification of testicular Tumors

WHO classifies testicular tumors as follows:[1][2]

Testicular Cancer
Germ cell tumors Sex-cord stromal tumors Miscellaneous tumors of the testis Hematolymphoid tumors Tumors of collecting duct and rete testis Tumors containing both germ cell and sex-cord stromal elements
Germ cell tumors derived from germ cell neoplasia in situ:

Germ cell tumors unrelated to germ cell neoplasia in situ:

  • Spermatocytic tumor
  • Teratoma, prepubertal-type
    • Dermoid cyst
    • Epidermoid cyst
    • Well-differentiated neuroendocrine tumor (monodermal teratoma)
  • Mixed teratoma and yolk sac tumor, prepubertal-type
  • Yolk sac tumor, prepubertal-type
  • Pure tumors
  • Leydig cell tumor
    • Malignant leydig cell tumor
  • Sertoli cell tumor
    • Malignant Sertoli cell tumor
    • Large cell calcifying Sertoli cell tumor
    • Intratubular large cell hyalinizing Sertoli cell neoplasia
  • Granulosa cell tumor
    • Adult granulosa cell tumor
    • Juvenile granulosa cell tumor
  • Tumors in the fibroma-thecoma group
  • Mixed and unclassified sex-stromal tumors
  • Mixed sex cord-stromal tumor
  • Unclassified sex cord-stromal tumor
Ovarian epithelial-type tumors
  • Serous cystadenoma
  • Serous tumor of borderline malignancy
  • Serous cystadenocarcinoma
  • Mucinous borderline tumor
  • Mucinous cystadenocarcinoma
  • Endometrioid adenocarcinoma
  • Clear cell adenocarcinoma
  • Brenner tumor

Juvenile Xanthogranuloma Hemangioma

  • Diffuse large B-cell lymphoma
  • Follicular lymphoma, NOS
  • Extranodal NK/T-cell lymphoma, nasal type
  • Plasmacytoma
  • Myeloid sarcoma
  • Rosai-Dorfman disease
  • Adenoma
  • Adenocarcinoma
  • Gonadoblastoma

References

  1. Williamson SR, Delahunt B, Magi-Galluzzi C, Algaba F, Egevad L, Ulbright TM, Tickoo SK, Srigley JR, Epstein JI, Berney DM (February 2017). "The World Health Organization 2016 classification of testicular germ cell tumours: a review and update from the International Society of Urological Pathology Testis Consultation Panel". Histopathology. 70 (3): 335–346. doi:10.1111/his.13102. PMID 27747907.
  2. Moch H, Cubilla AL, Humphrey PA, Reuter VE, Ulbright TM (July 2016). "The 2016 WHO Classification of Tumours of the Urinary System and Male Genital Organs-Part A: Renal, Penile, and Testicular Tumours". Eur. Urol. 70 (1): 93–105. doi:10.1016/j.eururo.2016.02.029. PMID 26935559.


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